Tobramycin sulfate is a Medicine belongs to Aminoglycoside antibiotic group whose information about Brand can be referenced from   Book : Martindale    Page : 385   Edition : 37,

  ►   Brandname : Tobacin,Tobazon,Bramitob,Tobrasol

  ►  Strength : Injection with 10  mg/ml, Injection with 40  mg/ml, Injection with   , ophthalmic suspension with   , Inhalation Solution with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 828   Edition : 12, Martindale    Page : 381   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Topical, IM, IV, inhalation,
Reference :-   Book : Martindale    Page : 385   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Antibacterial IM 3 5 mg/kg Injection Dose: Given daily 3 or 4 divided doses.
2 Urinary-tract infections IM 2 3 mg/kg Injection Dose: Given as a single intramuscular dose.
3 Dosing in Obesity: Critically ill patient, Give 7 mg/kg of Adjusted BW IV q24 h. Ref; The Sanford Guide To Antimicrobial Therapy, pg 231, ed 47

Ref :-  Book : Martindale    Page : 385   Edition : 37,    Page :    Edition : ,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 BACTERIAL MENINGITIS 0 Day 7 Day 5 mg/kg
2 BACTERIAL MENINGITIS 8 Day 28 Day 7.5 mg/kg
3 BACTERIAL MENINGITIS 7.5 mg/kg
4 BACTERIAL MENINGITIS 7.5 mg/kg
5 Cystic fibrosis lung infection IV 8 12 mg/kg/day Injection
6 Antibiotic 0 Week 4 Week <1,200 g IV 2.5 mg/kg Injection
7 Antibiotic 0 Week 4 Week <1,200 g IM 2.5 mg/kg Injection
8 Antibiotic >7 Day 1,200-2000 g IM 2 mg/kg Injection
9 Antibiotic >7 Day 1,200-2000 g IV 2 mg/kg Injection
10 Antibiotic 0 Day 7 Day 1,200-2,000 g IV 2 mg/kg Injection
11 Antibiotic 0 Day 7 Day 1,200-2,000 g IM 2 mg/kg Injection
12 Antibiotic 0 Day 7 Day >2,000 g IV 2 mg/kg Injection
13 Antibiotic 0 Day 7 Day >2,000 g IM 2 mg/kg Injection
14 Antibiotic >7 Day >2,000 g IV 2 mg/kg Injection
15 Antibiotic >7 Day >2,000 g IM 2 mg/kg Injection
16 Antibiotic 0 Week 4 Week <1,200 g IV 5 mg/kg Injection o.d.
17 Antibiotic 0 Week 4 Week <1,200 g IM 5 mg/kg Injection o.d.
18 Antibiotic 0 Day 7 Day 1,200-2,000 g IV 4 mg/kg Injection o.d.
19 Antibiotic 0 Day 7 Day 1,200-2,000 g IM 4 mg/kg Injection o.d.
20 Antibiotic >7 Day 1,200-2,000 g IV 4 mg/kg Injection o.d.
21 Antibiotic >7 Day 1,200-2,000 g IM 4 mg/kg Injection o.d.
22 Antibiotic 0 Day 7 Day >2,000 g IV 4 mg/kg Injection o.d.
23 Antibiotic 0 Day 7 Day >2,000 g IM 4 mg/kg Injection o.d.
24 Antibiotic >7Day > 2,000 IV 4 mg/kg Injection o.d.
25 Antibiotic >7 Day >2,000 g IM 4 mg/kg Injection o.d.

Ref :- Book : Nelson's textbook of Pediatrics    Page : 2093   Edition : 19, Nelson's textbook of Pediatrics    Page : 1492   Edition : 19, Nelson's textbook of Pediatrics    Page : 645   Edition : 19, Nelson's textbook of Pediatrics    Page : 645   Edition : 37, Martindale    Page : 645   Edition : 19,
Precaution :- If a Patient is using 'Tobramycin sulfate' drug in  MYASTHENIA GRAVIS  disease, then Please Use with caution .

►  Side Effect : Cumulative ototoxicity, hearing loss, Vestibular damage, Reversible nephrotoxicity, acute renal failure, Decreased glomerular filtration rate, Electrolyte disturbances (notably hypomagnesaemia, but also hypocalcaemia and hypokalaemia), , encephalopathy, confusion, lethargy, hallucinations, convulsions, and mental depression, Atrophy or fat necrosis at injection sites, meningeal irritation, arachnoiditis, , Hypersensitivity reactions after local use, blood dyscrasias, purpura, nausea and vomiting, stomatitis, and signs of liver dysfunction such as increased serum-aminotransferase values and increased serum-bilirubin concentrations,, neuromuscular-blocking action and respiratory depression and muscular paralysis,
Ref :-   Book : Martindale    Page : 306,380   Edition : 38,

►  Drug Interaction : Drug interaction of Tobramycin sulfate is with AMINOGLYCOSIDES , Cephalosporin , General anaesthetics , Opioids, , , ,  Vancomycin , Cyclosporine , Cisplatin , Fludarabine, Etacrynic acid, Furosemide , Dimenhydrinate , Zalcitabine,
Ref :-   Book : Martindale    Page : 307,381   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Use of other nephrotoxic drugs including other aminoglycosides, vancomycin, some cephalosporins, ciclosporin, cisplatin, and fludarabine or of potentially ototoxic drugs such as etacrynic acid and perhaps furosemide, may increase the risk of aminoglycoside toxicity. It has been suggested that use of an antiemetic such as dimenhydrinate may mask the early symptoms of vestibular ototoxicity. The neuromuscular-blocking properties of aminoglycosides may be sufficient to provoke severe respiratory depression in patients given general anaesthetics or opioids. There is a theoretical possibility that the antibacterial effects of aminoglycosides could be reduced by bacteriostatic antibacterials, but such combinations have been used successfully in practice. Renal excretion of zalcitabine may be reduced by aminoglycosides. Gentamicin may inhibit α-galactosidase activity and should not be used with agalsidase alfa or beta.,
Ref :-   Book : Martindale    Page : 307,380   Edition : 38,


►  Contraindication : Hypersensitivity, It should be avoided in patients with myasthenia gravis, and great care is required in patients with parkinsonism and other conditions characterised by muscular weakness., When tobramycin is given by inhalation with other inhaled drugs, they should be given first before the dose of tobramycin. After the first inhaled dose of tobramycin, patients should be monitored for bronchospasm and if it occurs, the test should be repeated using a bronchodilator. Peak flow should be measured before nebulisation and again after it, Peak flow should be measured before nebulisation and again after it, Caution should be exercised in the presence of severe haemoptysis. Renal function should be monitored before treatment and every six months during use.,
Ref :-   Book : Martindale    Page : 306,380   Edition : 38,
  ►  Mechanism of Action :   Reversible inhibitor of protein synthesis but the precise mechanism bactericidal activity drug is then actively transport across the cells membrane into the cytoplasm by oxygen dependent process aminoglycosides bind to specific 30 S subunit ribosomal protein. Protein synthesis by aminoglycosides in at least 3 ways 1. Interference with initiation complex of peptide formation. 2. Misreading of mRNA. 3. Breakup of polysomes into nonfunctional monosomes.,
Ref :-   Book : Martindale    Page : 307   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Thyme with Another pathway,

  ►  Pathway with its reference as follows :-
  • Antibacterial effect --- ( Souza, E., Stamford, T., Lima, E., Trajano, V., & Barbosa Filho, J. (2005). Antimicrobial effectiveness of spices: an approach for use in food conservation systems. Brazilian Archives Of Biology And Technology, 48(4), 549-558. )

  •   ►  URL -- http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000500007,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 385   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   2 hours,    Max value :-   3 hours,
    Ref :-   Book : Martindale    Page : 385   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   0.5 hour,    Max value :-   1.5 hour,
    Ref :-   Book : Martindale    Page : 385   Edition : 37,