Tobramycin sulfate is a Medicine belongs to Antibacterials group whose information about Brand can be referenced from   Book : Martindale    Page : 385   Edition : 37  

  ►   Brandname : Nebcin, Tobi, Brulamycin, Gernebcin, Ocutob, Tobacin, Bramitob, AkTob, Tobrasol
  ►  Strength : Injection with 10 mg/ml.  Injection with 40 mg/ml.  Injection with .  ophthalmic suspension with .  Inhalation Solution with .  Ophthalmic Ointment with

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 828   Edition : 12   Martindale    Page : 385   Edition : 37  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : ophthalmic, IM, IV, inhalation, Slow IV, IV infusion
Reference :-   Book : Martindale    Page : 385   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Antibacterial Tobramycin sulfate is given by intramuscular injection, or by intravenous infusion over 20 to 60 minutes in 50 to 100 mL of sodium chloride 0.9% or glucose 5% injection; proportionately less fluid should be given to children. It has also been given slowly by direct intravenous injection. Doses are expressed in terms of tobramycin base ; 1.5 g of tobramycin sulphate is equivalent to about 1 g of tobramycin
2 Mild to moderate urinary-tract infection IM 2 3 mg/kg Injection
3 Eye infections ophthalmic 0.3 % Eye ointment or eye drop

Ref :-  Book : Martindale    Page : 385   Edition : 37  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Severe infections caused by susceptible bacteria IM or IV 3 7.5 mg/kg Injection
2 Septicaemia, meningitis and other CNS infections, biliary-tract infection, acute pyelonephritis, and pneumonia 1 Month 12 Year Slow IV 2 2.5 mg/kg Injection
3 Septicaemia, meningitis and other CNS infections, biliary-tract infection, acute pyelonephritis, and pneumonia 12 Year 18 Year Slow IV 1 mg/kg Injection
4 Septicaemia, meningitis and other CNS infections, biliary-tract infection, acute pyelonephritis, and pneumonia 1 Month IV infusion 7 mg/kg Injection
5 Pseudomonal lung infection in cystic fibrosis 1 Month Slow IV 8 10 mg/kg Injection
6 Pseudomonal lung infection in cystic fibrosis 1 Month IV infusion 10 mg/kg Injection
7 Chronic infections 6 Year inhalation 300 mg
8 Neonatal sepsis Slow intravenous injection or intravenous infusion 4 5 mg/kg Injection
9 Neonatal sepsis Slow intravenous injection or intravenous infusion 4 5 mg/kg Injection
10 Neonatal sepsis 7 Day IM, slow IV injection or IV infusion 2 mg/kg Injection
11 Neonatal sepsis 7 Day 28 Day IM, slow IV injection or IV infusion 2 2.5 mg/kg Injection
12 Neonatal sepsis 0 Week 4 Week Less than 1.2 kg IM or IV 2.5 mg/kg Injection
13 Neonatal sepsis 1 Week 1.2 kg or more IM or IV 2.5 mg/kg Injection
14 Neonatal sepsis 1.2 to 2 kg IM or IV 2.5 mg/kg Injection
15 Neonatal sepsis More than 2 kg IM or IV 2.5 mg/kg Injection

Ref :- Book : Martindale    Page : 385   Edition : 37  
Precaution :- If a Patient is using 'Tobramycin sulfate' drug in  MYASTHENIA GRAVIS  disease, then Please Use with caution .

►  Side Effect : Cumulative ototoxicity, Hearing loss, Dizziness, Vertigo, Vestibular damage, Reversible nephrotoxicity, Acute renal failure, Acute tubular necrosis, Interstitial nephritis, Electrolyte disturbances (notably hypomagnesaemia, but also hypocalcaemia and hypokalaemia), Respiratory depression, Hypersensitivity reactions, Blood dyscrasias, Purpura, Nausea, Vomiting, Stomatitis, Increased serum-aminotransferase values, Increased serum-bilirubin concentrations, Neurotoxicity, Encephalopathy, Confusion, Lethargy, Hallucinations, Mental depression, Atrophy or fat necrosis has been reported at injection sites, Meningeal irritation, Arachnoiditis, Polyradiculitis, and ventriculitis after intrathecal, intracisternal, or intraventricular . Subconjunctival injection of gentamicin may lead to pain, hyperaemia, and conjunctival oedema., Severe retinal ischaemia
Ref :-   Book : Martindale    Page : 306,385   Edition : 37.  

►  Drug Interaction : Drug interaction of Tobramycin sulfate is with AMINOGLYCOSIDES , Cephalosporin , General anaesthetics , Opioids, , , ,  Vancomycin , Cyclosporine , Cisplatin , Fludarabine, Etacrynic acid, Furosemide , Dimenhydrinate , Zalcitabine
Ref :-   Book : Martindale    Page : 307,384   Edition : 37.  


  ►    Mechanism of Drug Drug Interaction :  Use of other nephrotoxic drugs including other aminoglycosides, vancomycin, some cephalosporins, ciclosporin, cisplatin, and fludarabine or of potentially ototoxic drugs such as etacrynic acid and perhaps furosemide, may increase the risk of aminoglycoside toxicity. It has been suggested that use of an antiemetic such as dimenhydrinate may mask the early symptoms of vestibular ototoxicity. The neuromuscular-blocking properties of aminoglycosides may be sufficient to provoke severe respiratory depression in patients given general anaesthetics or opioids. There is a theoretical possibility that the antibacterial effects of aminoglycosides could be reduced by bacteriostatic antibacterials, but such combinations have been used successfully in practice. Renal excretion of zalcitabine may be reduced by aminoglycosides. Gentamicin may inhibit α-galactosidase activity and should not be used with agalsidase alfa or beta.
Ref :-   Book : Martindale    Page : 307,384   Edition : 37.  


►  Contraindication : Hypersensitivity, It should be avoided in patients with myasthenia gravis, and great care is required in patients with parkinsonism and other conditions characterised by muscular weakness., When tobramycin is given by inhalation with other inhaled drugs, they should be given first before the dose of tobramycin. After the first inhaled dose of tobramycin, patients should be monitored for bronchospasm and if it occurs, the test should be repeated using a bronchodilator. Peak flow should be measured before nebulisation and again after it, Caution should be exercised in the presence of severe haemoptysis. Renal function should be monitored before treatment and every six months during use.
Ref :-   Book : Martindale    Page : 307,385   Edition : 37.   Martindale    Page : 306,380   Edition : 37.  
  ►  Mechanism of Action :   Aminoglycosides are taken up into sensitive bacterial cells by an active transport process which is inhibited in anaerobic, acidic, or hyperosmolar environments. Within the cell they bind to the 30S, and to some extent to the 50S, subunits of the bacterial ribosome, inhibiting protein synthesis and generating errors in the transcription of the genetic code. The manner in which cell death is brought about is imperfectly understood, and other mechanisms may contribute, including effects on membrane permeability.
Ref :-   Book : Martindale    Page : 308,385   Edition : 37.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Thyme with Another pathway.  

  ►  Pathway with its reference as follows :-
  • Antibacterial effect --- ( Souza, E., Stamford, T., Lima, E., Trajano, V., & Barbosa Filho, J. (2005). Antimicrobial effectiveness of spices: an approach for use in food conservation systems. Brazilian Archives Of Biology And Technology, 48(4), 549-558. )

  •   ►  URL --
  • http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000500007 .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   NA

    ►    Plasma Half-life :   Min value :-   2 hours,    Max value :-   3 hours.  
    Ref :-   Book : Martindale    Page : 385   Edition : 37.  

    ►    Peak Plasma Concentration :   Min value :-   30 minutes,    Max value :-   60 minutes.  
    Ref :-   Book : Martindale    Page : 385   Edition : 37.