Tolcapone is a Medicine belongs to Antiparkinsonian Drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 904   Edition : 37,

  ►   Brandname : Tasmar

  ►  Strength : Tablet with 100  mg, Tablet with 200  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 498   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 904   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Parkinson’s disease Oral 100 mg Tablet

Ref :-  Book : Martindale    Page : 904   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : behavioural disturbances, headache, increased sexual urge, increased sweating, anorexia, Dizziness, dyskinesia, dystonia, Confusion, excessive dreaming, hallucinations, Orthostatic hypotension, Somnolence, hepatic failure, hepatitis, increased liver enzyme values, sleep disorders, Neuroleptic malignant syndrome, rhabdomyolysis, yellow intensification in the colour of urine, diarrhea, nausea, vomiting, constipation, abdominal pain, dry mouth,
Ref :-   Book : Martindale    Page : 904   Edition : 37,

►  Drug Interaction : Drug interaction of Tolcapone is with Benserazide,
Ref :-   Book : Martindale    Page : 904   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Tolcapone may influence the pharmacokinetics of drugs metabolised by catechol-O-methyltransferase; a dose reduction of such drugs should be considered when given with tolcapone. Increased concentrations of benserazide and its active metabolite have been reported when given with tolcapone,
Ref :-   Book : Martindale    Page : 904   Edition : 37,


►  Contraindication : hepatic impairment, renal impairment, severe dyskinesia, Neuroleptic malignant syndrome, nontraumatic rhabdomyolysis, hyperpyrexia, phaeochromocytoma,
Ref :-   Book : Martindale    Page : 904   Edition : 37,
  ►  Mechanism of Action :   Tolcapone is a peripheral inhibitor of catechol-O-methyltransferase (COMT), an enzyme involved in the metabolism of dopamine and levodopa,
Ref :-   Book : Martindale    Page : 904   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Banana with Another pathway, Ashwagandha with Another pathway, Fava beans i.e. bakla with same compound, Green tea with same pathway, Myrica rubra with same pathwaysame pathway, Myrica rubra with same pathwaysame pathway,

  ►  Pathway with its reference as follows :-
  • Increased Dopamine level --- (K, K. (2000). High content of dopamine, a strong antioxidant, in Cavendish banana. J Agric Food Chem, 48(3). )
  • Increased Dopamine level --- ( Singh, N., Bhalla, M., De Jager, P., & Gilca, M. (2011). An Overview on Ashwagandha: A Rasayana (Rejuvenator) of Ayurveda. African Journal Of Traditional, Complementary And Alternative Medicines, 8(5S). )
  • Fava beans rich in levo-dihydroxyphenylalanine(L-Dopa) the precursor of dopamine. --- (Mehran S.M., Mohseni. "Simultaneous Determination Of Levodopa And Carbidopa From Fava Bean, Green Peas And Green Beans By High Performance Liquid Gas Chromatography". JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH (2013): n. pag. Web. 10 Nov. 2016. )
  • Catechin found in green tea act as COMT inhibitor ., --- ( D, C. (2015). Inhibition of human liver catechol-O-methyltransferase by tea catechins and their metabolites: structure-activity relationship and molecular-modeling studies. Biochem Pharmacol., 69(10), )
  • Myricitrin found in myrica rubra act as COMT inhibitor. --- ( Hong, Y. (2014). Inhibition of catechol-o-methyltransferase (COMT) by myricetin, dihydromyricetin, and myricitrin. International Journal Of Pharmacutical Science, 69(3), 183-186(4). )
  • Dihydromyricetin found in myrica rubra act as COMT inhibitor. --- ( Hong, Y. (2014). Inhibition of catechol-o-methyltransferase (COMT) by myricetin, dihydromyricetin, and myricitrin. International Journal Of Pharmacutical Science, 69(3), 183-186(4). )
  • Myricitrin found in myrica rubra act as COMT inhibitor. --- ( Hong, Y. (2014). Inhibition of catechol-o-methyltransferase (COMT) by myricetin, dihydromyricetin, and myricitrin. International Journal Of Pharmacutical Science, 69(3), 183-186(4). )
  • Dihydromyricetin found in myrica rubra act as COMT inhibitor. --- ( Hong, Y. (2014). Inhibition of catechol-o-methyltransferase (COMT) by myricetin, dihydromyricetin, and myricitrin. International Journal Of Pharmacutical Science, 69(3), 183-186(4). )

  •   ►  URL -- http://www.ncbi.nlm.nih.gov/pubmed/10725161, Singh, N., Bhalla, M., De Jager, P., & Gilca, M. (2011). An Overview on Ashwagandha: A Rasayana (Rejuvenator) of Ayurveda. African Journal Of Traditional, Complementary And Alternative Medicines, 8(5S). http://dx.doi.org/10.4314/ajtcam.v8i5s.9, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708185/, https://www.ncbi.nlm.nih.gov/pubmed/15857617, http://www.ingentaconnect.com/content/govi/pharmaz/2014/00000069/00000003/art00004,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Fecal, Renal,
    Ref :-   Book : Martindale    Page : 904   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   2 hours,    Max value :-   3 hours,
    Ref :-   Book : Martindale    Page : 904   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 904   Edition : 37,