Tolvaptan is a Medicine belongs to V2-receptor antagonist group whose information about Brand can be referenced from   Book : Martindale    Page : 270   Edition : 12,

  ►   Brandname : Samsca

  ►  Strength : Tablet with 15  mg, Tablet with 30  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 270   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Goodman    Page : 714   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Oral 15 mg Tablet o.d.

Ref :-  Book : Martindale    Page : 2641   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : hyperglycemia, Hyperglycaemia, pyrexia, Cerebrovascular accident, deep venous thrombosis, Intravascular coagulation and thrombosis, intra cardiac thrombus, ventricular fibrillation, urethral hemorrhage, vaginal hemorrhage, pulmonary embolism, respiratory failure, diabetic ketoacidosis, ischemic colitis, increase in prothrombin time, rhabdomyolysis, GI effects, dry mouth, abnormal liver fuction tests,
Ref :-   Book : Goodman    Page : 714   Edition : 12, Goodman    Page : 714   Edition : 2,

►  Drug Interaction : Drug interaction of Tolvaptan is with Clarithromycin , Ketoconazole , Indinavir, Itraconazole , Nefazodone, nelfinavir, Ritonavir, Saquinavir, Telithromycin, Diltiazem , Erythromycin , Fluconazole , Verapamil , Rifampicin , Rifabutin , Rifapentine , Norgestrienone , Carbamazapine , Phenytoin , Cyclosporine , , Sertraline, Temazepam ,
Ref :-   Book : Martindale    Page : 2641   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  The use of tolvaptan with potent CYP3A4 inhibitors such as clarithromycin, ketoconazole, , indinavir, itraconazole, nefazodone, nelfinavir, ritonavir, saquinavir, and telithromycin is contraindicated. Use of tolvaptan with moderate nCYP3A4 inhibitors such as aprepitant, diltiazem, erythromycin, fluconazoleand verapamil should also be avoided on theoretical grounds that an increase in tolvaptan concentrations would also be expected. Rifampicin is a CYP3A4 inducer and significantly reduces tolvaptan concentrations. It is expected that other CYP3A4 inducers such as rifabutin, rifapentine, barbiturates, carbamazepine, phenytoin would have the same effect. Cyclosporin or grapefruit juice may increase tolvaptan concentrations. Hyperkalaemia has been reported in patients taking tolvaptan at same time as angiotensin II receptor antagonists, ACE inhibitors, or potassium sparing diuretics.,
Ref :-   Book : Martindale    Page : 2641   Edition : 37,


►  Contraindication : , CYP3A4 inhibitors , hyponatremia,
Ref :-   Book : Martindale    Page : 2641   Edition : 37,
  ►  Mechanism of Action :   Selective vasopressin V2 -receptor antagonist. ,
Ref :-   Book : Martindale    Page : 2641   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal,
Ref :-   Book : Goodman    Page : 714   Edition : 12,


►    Plasma Half-life :
  Min value :-   6 hours,    Max value :-   8 hours,
Ref :-   Book : Goodman    Page : 714   Edition : 12,

►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   4 hours,
Ref :-   Book : Martindale    Page : 2641   Edition : 37,