Topiramate is a Medicine belongs to Antiseizure drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 553   Edition : 37,

  ►   Brandname : Topamac,Topamate,Topamax,Topirex

  ►  Strength : Tablet with 25  mg, Tablet with 50  mg, Tablet with 100  mg, Tablet with 200  mg, Capsule with 15  mg, Capsule with 25  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 427   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 552   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Epilepsy Oral 25 50 mg Tablet Dose: Given at night for 1 week.
2 Prophylaxis of migraine Oral 25 mg Tablet Dose: Given at night for 1 week.

Ref :-  Book : Martindale    Page : 552   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Epilepsy 2 Year Oral 25 mg Tablet o.d.
2 Epilepsy 6 Year Oral 0.5 1 mg/kg Tablet

Ref :- Book : Martindale    Page : 552   Edition : 37,
►  Side Effect : abdominal pain, agitation, anorexia, anxiety, asthenia, ataxia, Confusion, difficulty with memory, diplopia, Dizziness, drowsiness, emotional lability, fatigue, hypoaesthesia, impaired concentration, leucopenia, mood disorder, nausea, Nervousness, nystagmus, acute myopia, altered taste, hyperthermia, impaired speech, insomnia, psychomotor retardation, Reduced sweating, secondary angle-closure glaucoma, visual disturbances, weight loss,
Ref :-   Book : Martindale    Page : 551   Edition : 37,

►  Drug Interaction : Drug interaction of Topiramate is with Carbamazapine , Phenobarbital , Phenytoin ,
Ref :-   Book : Martindale    Page : 551   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  There are complex interactions between antiepileptics and toxicity may be enhanced without a corresponding increase in antiepileptic activity. Such interactions are very variable and unpredictable and plasma monitoring is often advisable with combination therapy,
Ref :-   Book : Martindale    Page : 551   Edition : 37,


►  Contraindication : hepatic impairment, renal impairment,
Ref :-   Book : Martindale    Page : 551   Edition : 37,
  ►  Mechanism of Action :   Topiramate reduces voltage-gated Na+ currents in cerebellar granule cells and may act on the inactivated state of the channel similar to phenytoin. In addition, topiramate activates a hyperpolarizing K+ current, enhances postsynaptic GABAA-receptor currents, and limits activation of the AMPA-kainate-subtype(s) of glutamate receptor. Topiramate is a weak carbonic anhydrase inhibitor. Topiramate inhibits maximal electroshock and pentylenetetrazol-induced seizures as well as partial and secondarily generalized tonic-clonic seizures in the kindling model, findings predictive of a broad spectrum of anti-seizure actions clinically,
Ref :-   Book : Goodman    Page : 601   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Gotu Kola with Another pathway, European peony flower with Another pathway, Sausage tree i.e.Balam khira with Another pathway,

  ►  Pathway with its reference as follows :-
  • Anti-Epilepsy --- (Kokate, C. & Purohit, A. (2013). Pharmacognosy. Nirali prakashan: Chennai. )
  • European Peony Flowers-Anthocyans have Anti-Epilepsy --- (Pdr For Herbal Medicine. 4th ed. 2016. Print. )
  • Anticonvulsion effect --- (Duke, J. (2002). Hand Book Of Medicinal Herbs (2nd ed.). United States Of America: CRC Press. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html, http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf, Duke, J. (2002). Hand Book Of Medicinal Herbs (2nd ed.). United States Of America: CRC Press.,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- CALCIUM with Long-term develop below normal blood levels of calcium , which may be related to drug -induced vitamin -D deficiency. .,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Goodman    Page : 601   Edition : 12,


    ►    Plasma Half-life :
      Min value :-   24 hours,    Max value :-   NA
    Ref :-   Book : Goodman    Page : 601   Edition : 12,

    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 551   Edition : 37,