Topotecan is a Medicine belongs to Antineoplastic group whose information about Brand can be referenced from   Book : Martindale    Page : 861   Edition : 37,

  ►   Brandname : Topotel,Hycamtin

  ►  Strength : Injection with NF  ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page :    Edition : ,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV, Oral,
Reference :-   Book : Martindale    Page : 861   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Ovarian cancers IV infusion 1.5 mg/m2 Injection Dose: Infused over 30 minutes, on day 1 to 5 of a 21 day course.
2 Small cell lung cancer IV infusion 1.5 mg/m2 Injection Dose: Infused over 30 minutes, on day 1 to 5 of a 21 day course.
3 Small cell lung cancer Oral 2.3 mg/m2 Tablet o.d.
4 Cervical cancer IV infusion 750 mcg/m2 Injection Dose: Infused over 30 minutes on a day 1, 2 and 3 of a 21 day course; cisplatin 50 mg/m2 is given intravenous infusion after topotecan on day 1.

Ref :-  Book : Martindale    Page : 861   Edition : 37, Martindale    Page : 862   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : neutropenia, Febrile neutropenia, sepsis, neutropenic colitis, fatalities, thrombocytopenia, anaemias, leucopenia, gastrointestinal disturbance, anorexia, anaphylaxis,
Ref :-   Book : Martindale    Page : 861   Edition : 37,

►  Drug Interaction : Drug interaction of Topotecan is with Cyclosporine , Cisplatin ,
Ref :-   Book : Martindale    Page : 861   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  nf,
Ref :-   Book :    Page :    Edition : ,


►  Contraindication : bone marrow depression, hepatic impairment, renal impairment, Breast feeding,
Ref :-   Book : Martindale    Page : 861   Edition : 37,
  ►  Mechanism of Action :   The drug function as a mitotic spindle poison through high-affinity binding to microtubules with enhancement of tubulin polymerization. This promotion of microtubule assembly by Topotecan occurs in the absence of microtubule-associated proteins and guanosine triphosphate and results in inhibition of mitosis and cell division,
Ref :-   Book : Martindale    Page : 809   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Mayapple i e ban kakri with Another pathway,

  ►  Pathway with its reference as follows :-
  • Etoposide have anticancer effect --- (Duke, J. (2002). Handbook of Medicinal Herbs (2nd ed.). CRC press: Boca Raton Road New York Washington ,D.C . )

  •   ►  URL -- https://www.crcpress.com/Handbook-of-Medicinal-Herbs-Second-Edition/Duke/p/book/9780849312847,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 861   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   nf,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : ,

    ►    Peak Plasma Concentration :   Min value :-   1 hour,    Max value :-   2 hours,
    Ref :-   Book : Martindale    Page : 861   Edition : 37,