Topotecan is a Medicine belongs to Antineoplastic group whose information about Brand can be referenced from   Book : Martindale    Page : 861   Edition : 37  

  ►   Brandname : Topotel, Hycamtin
  ►  Strength : Injection with

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 861   Edition : 37  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV, Oral
Reference :-   Book : Martindale    Page : 861   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Ovarian and Small cell lung cancer IV infusion 1.5 mg/m2 Injection Dose: Infused over 30 minutes, on day 1 to 5 of a 21 day course.
2 Small cell lung cancer Oral 2.3 mg/m2 o.d.
3 Cervical cancer IV infusion 750 mcg/m2 Injection Dose: Infused over 30 minutes on a day 1, 2 and 3 of a 21 day course; cisplatin 50 mg/m2 is given intravenous infusion after topotecan on day 1.

Ref :-  Book : Martindale    Page : 861-862   Edition : 37  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1

Ref :- Book :    Page :    Edition :   
►  Side Effect : Neutropenia, Febrile neutropenia, Sepsis, Neutropenic colitis, Fatalities, Thrombocytopenia, Anaemias, leucopenia, Gastrointestinal disturbance, Anorexia, Severe diarrhoea, Fatigue, Weakness, Alopecia, Malaise, pruritus, Pyrexia, Hyperbilirubinaemia
Ref :-   Book : Martindale    Page : 861   Edition : 37.  

►  Drug Interaction : Drug interaction of Topotecan is with Cyclosporine , Docetaxel
Ref :-   Book : Martindale    Page : 861   Edition : 37.  


  ►    Mechanism of Drug Drug Interaction :  For a report of topotecan reducing the clearance of docetaxel. Greater myelosuppression is seen when topotecan is used with other cytotoxic drugs, which may require dosage reductions of either drug. However, with platinum drugs, there is a sequence-dependent interaction; giving a platinum drug on the first day of topotecan dosage requires lower doses of each, compared with giving it on the fifth day. Granulocyte colony-stimulating factor can prolong the duration of neutropenia if given with topotecan, so if used, it should not be started until, 24 hours after topotecan dosage is complete. Ciclosporin has been reported to increase exposure to topotecan.
Ref :-   Book : Martindale    Page : 861   Edition : 37.  


►  Contraindication : Hepatic impairment, Renal impairment, Breast feeding
Ref :-   Book : Martindale    Page : 861   Edition : 37.  
  ►  Mechanism of Action :   Topotecan is a semisynthetic derivative of the alkaloid camptothecin. The camptothecin derivatives are inhibitors of the enzyme topoisomerase I and thus interfere with the coiling and uncoiling of DNA during replication and prevent nucleic acid synthesis. This action is specific for S phase.
Ref :-   Book : Martindale    Page : 809   Edition : 37.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Mayapple i e ban kakri with Another pathway.  

  ►  Pathway with its reference as follows :-
  • Etoposide have anticancer effect --- (Duke, J. (2002). Handbook of Medicinal Herbs (2nd ed.). CRC press: Boca Raton Road New York Washington ,D.C . )

  •   ►  URL --
  • https://www.crcpress.com/Handbook-of-Medicinal-Herbs-Second-Edition/Duke/p/book/9780849312847 .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal
    Ref :-   Book : Martindale    Page : 861   Edition : 37.  

    ►    Plasma Half-life :   Min value :-   NA    Max value :-   NA

    ►    Peak Plasma Concentration :   Min value :-   1 hour,    Max value :-   2 hours.  
    Ref :-   Book : Martindale    Page : 861   Edition : 37.