Torasemide is a Medicine belongs to Diuretic Agents group whose information about Brand can be referenced from   Book : Martindale    Page : 1554   Edition : 37      Page :   Edition :   

  ►   Brandname : Demadex, Torem, Dytor, Dytor Plus
  ►  Strength : Tablet with 5 mg.  Tablet with 10 mg.  Tablet with 20 mg.  Tablet with 100 mg.  Injection with 10 mg/ml. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 270   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV
Reference :-   Book : Martindale    Page : 1554   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Oedema Oral 5 mg Tablet o.d. Dose: Increased according to response to 20 mg once daily; doses of up to 40 mg daily have been required in some patients.
2 Oedema IV 10 20 mg Injection Dose given daily, Higher doses may sometimes be necessary, especially in oedema of renal origin; the dose should be increased stepwise as necessary to a maximum of 200 mg daily, although doses should not exceed 40 mg daily in patients with hepatic cirrhosis.
3 hypertension Oral 2.5 5 mg Tablet Dose given daily.

Ref :-  Book : Martindale    Page : 1554   Edition : 37  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
Precaution :- If a Patient is using 'Torasemide' drug in acute kidney injury disease, then Please should not be used   if he ever suffered from PERICARDIAL EFFUSION disease.
►  Side Effect : Fluid and electrolyte imbalance, Hyponatraemia, Hypokalaemia, Hypochloraemic alkalosis, Headache, Hypotension, Muscle cramp, Dry mouth, Thirst, Weakness, Lethargy, Drowsiness, Restlessness, Oliguria, Cardiac arrhythmias, Gastrointestinal disturbances, Hypovolaemia, Dehydration, Hyperuricaemia, Pancreatitis, Cholestatic jaundice, Blurred Vision, Yellow vision, Dizziness, Orthostatic hypotension
Ref :-   Book : Martindale    Page : 1421,1553   Edition : 37.  

►  Drug Interaction : Drug interaction of Torasemide is with , Beta 2 Agonist, Alpha blocker, Angiotensin conveting enzyme inhibitors , Alcohol, Barbiturates , Opioids, Corticosteroids, Non Sterodial Anti- Inflammatory Drugs , , TETRACYCLINES , ,  Astemizole, Terfenadine, Pimozide , Halofantrine, Sotalol , Atracurium , Corticotropin , Salbutamol , Carbenoxolone, Amphotericin B , Reboxetine, Noradrenaline/Norepinephrine , Allopurinol , Cefalotin
Ref :-   Book : Martindale    Page : 1423,1440,1553   Edition : 37.  

  ►    Mechanism of Drug Drug Interaction :  Many of the interactions of hydrochlorothiazide and other thiazides are due to their effects on fluid and electrolyte balance. Diuretic-induced hypokalaemia may enhance the toxicity of digitalis glycosides and may also increase the risk of arrhythmias with drugs that prolong the QT interval, such as astemizole, terfenadine, halofantrine, pimozide, and sotalol. Thiazides may enhance the neuromuscular blocking action of competitive neuromuscular blockers, such as atracurium, probably by their hypokalaemic effect. The potassium- depleting effect of diuretics may be enhanced by corticosteroids, corticotropin, beta2 agonists such as salbutamol, carbenoxolone, amphotericin B, or reboxetine. Diuretics may enhance the effect of other antihypertensives, particularly the first-dose hypotension that occurs with alpha blockers or ACE inhibitors. Orthostatic hypotension associated with diuretics may be enhanced by alcohol, barbiturates, or opioids. The antihypertensive effects of diuretics may be antagonised by drugs that cause fluid retention, such as corticosteroids, NSAIDs, or carbenoxolone; diuretics may enhance the nephrotoxicity of NSAIDs. Thiazides have been reported to diminish the response to pressor amines, such as noradrenaline, but the clinical significance of this effect is uncertain. Thiazides should not usually be used with lithium since the association may lead to toxic blood concentrations of lithium. Other drugs for which increased toxicity has been reported when given with thiazides include allopurinol and tetracyclines. Thiazides may alter the requirements for hypoglycaemics in diabetic patients. torasemide may enhance the nephrotoxicity of cephalosporin antibacterials such as cefalotin and can enhance the ototoxicity of aminoglycoside antibacterials and other ototoxic drugs.
Ref :-   Book : Martindale    Page : 1423,1440,1553   Edition : 37.  

►  Contraindication : Existing fluid and electrolyte disturbances, Severe hepatic impairment, Addison’s disease , Severe renal impairment, Anuria, Preexisting hypercalcaemia, Pre-comatose states associated with hepatic cirrhosis, It should be used with care in patients with prostatic hyperplasia or impairment of micturition since it can precipitate acute urinary retention, It should be used with caution during pregnancy and breast feeding since it crosses the placenta and also appears in breast milk.
Ref :-   Book : Martindale    Page : 1422,1440,1553   Edition : 37.  
  ►  Mechanism of Action :   Inhibit sodium reabsorption by reversibly and competitively inhibiting sodium- potassium chloride co transporter NKCC2 in apical (luminal) membrane of cells in thick ascending limb of loop of henle; also reduce or abolish the lumen positive transepithelial potential difference.
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 351   Edition : 3.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA

DIETARY Substance Interactions

​   ► This Medicine interact with :- NA

ContraIndication DIETARY Substance

​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal
Ref :-   Book : Martindale    Page : 1553   Edition : 37.  

►    Plasma Half-life :   Min value :-   3.5 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 1553   Edition : 37.  

►    Peak Plasma Concentration :   Min value :-   1 hour,    Max value :-   NA
Ref :-   Book : Martindale    Page : 1553   Edition : 37.