Toremifene is a Medicine belongs to Antineoplastic group whose information about Brand can be referenced from   Book : Martindale    Page : 862   Edition : 37  

  ►   Brandname : Fareston
  ►  Strength : Tablet with

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 862   Edition : 37  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 862   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Metastatic breast cancer in postmenopausal women with oestrogen-receptor positive tumours Oral 60 mg Tablet o.d.

Ref :-  Book : Martindale    Page : 862   Edition : 37  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1

Ref :- Book :    Page :    Edition :   
►  Side Effect : Hot flashes, Fluid retention, Nausea, Gastrointestinal intolerance, Vaginal bleeding or discharge, Pruritus vulvae, Rashes, Dry skin, Alopecia, Dizziness, Headache, Depression, Confusion, Fatigue, Muscle cramps, Transient thrombocytopenia, Leukopenia, Hypertriglyceridaemia, Uterine fibroids, Hyperplasia, Polyps, Increased incidence of endometrial carcinoma, Suppression of menstruation may occur in premenopausal women and cystic ovarian swellings
Ref :-   Book : Martindale    Page : 853, 862   Edition : 37.  

►  Drug Interaction : Drug interaction of Toremifene is with Azole Antifungal, Macrolide antibacterials, Antiarrhythmics, Antipsychotics, , Antimalarials, , ,  Phenytoin , Phenobarbital , Carbamazapine , Phenothiazine, Pimozide , Sertindole, Haloperidol , Sultopride, Moxifloxacin , Erythromycin , Pentamidine , Halofantrine, Terfenadine, Astemizole, Mizolastine, Cisapride , Vincamine, Bepridil
Ref :-   Book : Martindale    Page : 862   Edition : 37.  


  ►    Mechanism of Drug Drug Interaction :  Toremifene is metabolised by cytochrome P450 isoenzyme CYP3A4, and potent enzyme-inducing drugs such as phenytoin, phenobarbital and carbamazepine, can increase toremifene metabolism, thereby lowering the serum concentration; dose adjustment of toremifene may be needed. Conversely, azole antifungals and macrolide antibacterials may theoretically inhibit toremifene metabolism by inhibiting the isoenzyme. Toremifene should not be used with drugs that prolong the QT interval, such as antiarrhythmics, antipsychotics (such as phenothiazines, pimozide, sertindole, haloperidole, and sultopride), certain antimicrobials ( such as moxifloxacin, erythromycin, pentamidine, and antimalarials, particularly halofantrine), certain antihistamines ( terfinadine, astemazole, mizolastine) and other drugs such as cysapride, vincamine, bepridil, and diphemanil. Use with drugs that decrease renal calcium excretion, such as thiazide diuretics, may increase the incidence of hypercalcaemia. Use with coumarin anticoagulants should be avoided as there is a risk of increased bleeding time.
Ref :-   Book : Martindale    Page : 862   Edition : 37.  


►  Contraindication : In patients with pre-existing endometrial hyperplasia, or in those with severe thromboembolic disease or severe hepatic impairment., Patients with QT prolongation, electrolyte disturbances (especially uncorrected hypokalaemia) , or in those with bradycardia, heart failure, or a history of arrhythmias
Ref :-   Book : Martindale    Page : 862   Edition : 37.  
  ►  Mechanism of Action :   It stimulates the secretion of pituitary gonadotrophic hormones, probably by blocking the negative feedback effect of oestrogens at receptor sites in the hypothalamus and pituitary It may also inhibit the production or release of cellular growth factors and induce apoptosis.
Ref :-   Book : Martindale    Page : 855,862,2291   Edition : 37.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


DIETARY Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication DIETARY Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal, Faecal
Ref :-   Book : Martindale    Page : 862   Edition : 37.  

►    Plasma Half-life :   Min value :-   NA    Max value :-   NA

►    Peak Plasma Concentration :   Min value :-   3 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 862   Edition : 37.