Tramadol is a Medicine belongs to Analgesic opoids group whose information about Brand can be referenced from   Book : Martindale    Page : 147   Edition : 37,    Page :   Edition : ,

  ►   Brandname : Contramal,Tramacip,Tramazac,Dromadol,Larapam,Mabron,Ultram,Ultracet

  ►  Strength : Tablet with 50  mg, Tablet (Extended Release Tablets) with 100  mg, Tablet (Extended Release Tablets) with 200  mg, Tablet (Extended Release Tablets) with 300  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 562   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV, IM, rectal,
Reference :-   Book : Martindale    Page : 137   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Analgesic Oral 50 100 mg Dose: Given every 4 to 6 hours.
2 Analgesic Oral 50 100 mg
3 Analgesic IV 50 100 mg Injection Dose: Given over 2 to 3 minutes.
4 Analgesic IM 50 100 mg Injection Dose: Given over 2 to 3 minutes.
5 Analgesic IV infusion 50 100 mg Injection Dose: Given over 2 to 3 minutes.
6 Analgesic rectal 100 mg Suppository Dose: Given up to 4 times daily.

Ref :-  Book : Martindale    Page : 137   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
Precaution :- If a Patient is using 'Tramadol' drug in  Generalized, Tonic-Clonic Seizures  disease, then Please Not to be given .

►  Side Effect : nausea, vomiting, drowsiness, Confusion, dry mouth, Dizziness, sweating, facial flushing, headache, vertigo, bradycardia, tachycardia, palpitations, Orthostatic hypotension, hypothermia, Restlessness, changes of mood, decreased libido, hallucinations, Miosis, respiratory depression, constipation, hypotension, hypertension,
Ref :-   Book : Martindale    Page : 106, 136   Edition : 37,

►  Drug Interaction : Drug interaction of Tramadol is with Carbamazapine , Felbamate, , Pramlintide , Warfarin ,
Ref :-   Book : Martindale    Page : 136,137   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Carbamazepine is reported to diminish the analgesic activity of tramadol by reducing serum concentrations. The risk of seizures is increased if tramadol is used with other drugs that have the potential to lower the seizure threshold. Tramadol inhibits reuptake of noradrenaline and serotonin and enhances serotonin release and there is the possibility that it may interact with other drugs that enhance monoaminergic neurotransmission including lithium, tricyclic antidepressants, and SSRIs; it should not be given to patients receiving MAOIs or within 14 days of their discontinuation.,
Ref :-   Book : Martindale    Page : 136   Edition : 37,


►  Contraindication : respiratory depression, Obstructive airway disease, acute alcoholism, head trauma, hepatic impairment, renal impairment, prostatic hyperplasia, , inflammatory or obstructive bowel disorders, myasthenia gravis,
Ref :-   Book : Martindale    Page : 107   Edition : 37,
  ►  Mechanism of Action :   Tramadol is a centrally acting analgesic whose mechanism of action is predominantly based on blockade of serotonin reuptake. Tramadol has also been found to inhibit norepinephrine transporter function. Because it is only partially antagonized by naloxone, it is believed to be only a weak μ-receptor agonist. ,
Ref :-   Book : Basic & Clinical pharmacology    Page : 559   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- sassafras albidum i. e.cinnamon wood with Another pathway, Chickpea with Another pathway, Chaulmoogra with Another pathway,

  ►  Pathway with its reference as follows :-
  • Naucleamides A have antidepressent effect --- ( Duke, J. (2002). Handbook of Medicinal Herbs (2nd ed.). CRC press: Boca Raton Road New York Washington ,D.C . )
  • Naucleamides -F have antidepressent effect --- (Duke, J. (2002). Handbook of Medicinal Herbs (2nd ed.). CRC press: Boca Raton Road New York Washington ,D.C . )
  • Quinouic acid have antidepressent effect --- (Duke, J. (2002). Handbook of Medicinal Herbs (2nd ed.). CRC press: Boca Raton Road New York Washington ,D.C . )

  •   ►  URL -- https://www.crcpress.com/Handbook-of-Medicinal-Herbs-Second-Edition/Duke/p/book/9780849312847,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Hepatic (Metabolism), Renal,
    Ref :-   Book : Goodman    Page : 508   Edition : 12,


    ►    Plasma Half-life :
      Min value :-   6 hours,    Max value :-   NA
    Ref :-   Book : Goodman    Page : 508   Edition : 12,

    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   3 hours,
    Ref :-   Book : Goodman    Page : 508   Edition : 12,