Tranexamic acid is a Medicine belongs to Antifibinolytic group whose information about Brand can be referenced from   Book : Martindale    Page : 1192, 1420   Edition : 37,

  ►   Brandname : Cyklokapron,Tranarest

  ►  Strength : Tablet with 500  mg, Injection with 100  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 617   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV,
Reference :-   Book : Martindale    Page : 1191   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Haemorrhage Oral 1 1.5 gm Tablet b.d/t.i.d
2 Haemorrhage slow i.v 0.5 1 gm Injection t.i.d.
3 Haemorrhage continuous i.v infusion 25 50 mg/kg Injection Dose: Given daily.
4 Menorrhagia Oral 4 gm Tablet Dose: Given daily.
5 Hereditary angioedema Oral 1 1.5 gm Tablet b.d/t.i.d
6 Neutralization of thrombolytic therapy slow i.v 10 mg/kg Injection

Ref :-  Book : Martindale    Page : 1191   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Prophylaxis of haemmorhage associated with excessive fibrinolysis Oral 15 25 mg/kg Tablet b.d/t.i.d
2 Prophylaxis of haemmorhage associated with excessive fibrinolysis IV 10 mg/kg Injection b.d/t.i.d
3 Hereditary angioedema Oral 50 mg/kg Tablet

Ref :- Book : Martindale    Page : 1192   Edition : 37,
Precaution :- If a Patient is using 'Tranexamic acid' drug in  Prevention of Excessive bleeding  disease, then Please Contraindication: Stroke, MI, subarchanoid haemorrahage .

►  Side Effect : GI disturbances, hypotension, Dizziness, hypersensitivity reactions, musculoskeletal pain, convulsion, transient disturbance of colour vision,
Ref :-   Book : Martindale    Page : 1191, 1420   Edition : 37,

►  Drug Interaction : Drug interaction of Tranexamic acid is with Pramipexole , , Glibenclamide ,
Ref :-   Book : Martindale    Page : 10191   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  The risk of thrombosis may be increased if tranexamic acid is given with IX complex concentrates or factor VIII inhibitor by passing fraction, and such combination are not recommended. Antifibrinolytics and thrombolytic have antagonistic effects, and concomitant use may reduce the efficacy of both. The potential for thrombus formation may be increased by oestrogens.,
Ref :-   Book : Martindale    Page : 1191,1420   Edition : 37,


►  Contraindication : intravascular clotting,
Ref :-   Book : Martindale    Page : 1420   Edition : 37,
  ►  Mechanism of Action :   It is an analogue of lysine that bind to and inhibit plasminogen and plasmin,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 400   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Green leafy vegetables with Another pathway,

  ►  Pathway with its reference as follows :-
  • Vitamin K is a hepatic precursors of Coagulation factor II --- (PDR for herbal medicine. (2016) (4th ed.). Thomson Reuters, 2007. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 1191   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   2 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1191   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   3 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1191   Edition : 37,