Trastuzumab is a Medicine belongs to Antineoplastic group whose information about Brand can be referenced from   Book : Martindale    Page : 865   Edition : 37,

  ►   Brandname : Herceptin

  ►  Strength : Injection with 440  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 999   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV,
Reference :-   Book : Martindale    Page : 865   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Metastatic breast cancer IV infusion 4 mg/kg Injection Dose: Given in 250 ml of sodium chloride 0.9% over 90 minutes.
2 Metastatic gastric cancer IV infusion 8 mg/kg Injection Dose: Given by intravenous infusion in 250 mL of sodium chloride 0.9% over 90 minutes.

Ref :-  Book : Martindale    Page : 865   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : hypersensitivity reactions, cytokine release syndrome, acute respiratory distress syndrome, reduced lung function, gastrointestinal disturbance, chills, fever, headache, arthralgia, myalgia, Rashes, asthenia, chest pain, liver disorders, renal failure,
Ref :-   Book : Martindale    Page : 865   Edition : 37,

►  Drug Interaction : Drug interaction of Trastuzumab is with Warfarin ,
Ref :-   Book : Martindale    Page : 865   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  trastuzumab enhancing the effect of warfarin,
Ref :-   Book : Martindale    Page : 865   Edition : 37,


►  Contraindication : severe dyspnoea, cardiac impairment, congestive heart failure,
Ref :-   Book : Martindale    Page : 865   Edition : 37,
  ►  Mechanism of Action :   Binds to ErbB2 (HER2/neu) cell surface receptor and controls cancer cell growth,
Ref :-   Book : Martindale    Page : 865   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   NA


►    Plasma Half-life :
  Min value :-   139.2 hours,    Max value :-   NA
Ref :-   Book : Goodman    Page : 1737   Edition : 12,

►    Peak Plasma Concentration :   Min value :-   2688 hours,    Max value :-   NA
Ref :-   Book : Goodman    Page : 1737   Edition : 12,