Trazodone is a Medicine belongs to Antidepressant group whose information about Brand can be referenced from   Book : Martindale    Page : 457   Edition : 37  

  ►   Brandname : Molipaxin, Desyrel, Oleptro, Thombran
  ►  Strength : Tablet with 50 mg.  Tablet with 100 mg.  Tablet with 150 mg.  Tablet with 300 mg.  Capsule with

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 539   Edition : 12   Martindale    Page : 456   Edition : 37  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 456   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Depression Oral 150 mg Tablet Dose given daily. Dosage may be increased by 50 mg every 3 or 4 days up to 300 to 400 mg daily if necessary. The daily dosage may be divided throughout the day after food or be given as a single dose at night.
2 Anxiety Oral 75 mg Tablet Dose: Given daily and increasing to 300 mg daily if necessary.

Ref :-  Book : Martindale    Page : 456   Edition : 37  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Depression Oral 25 150 mg Tablet

Ref :- Book : Nelson's textbook of Pediatrics    Page : 63   Edition : 19  
►  Side Effect : Drowsiness, Dizziness, Headache, Nausea, Vomiting, Weakness, Weight loss, Tremor, Dry mouth, Bradycardia, Tachycardia, Orthostatic hypotension, Oedema, Constipation, Diarrhea, Blurred Vision, Restlessness, Confusional states, Insomnia, Rashes, Jaundice, Hepatocellular damage
Ref :-   Book : Martindale    Page : 456   Edition : 37.  

►  Drug Interaction : Drug interaction of Trazodone is with Alcohol, CNS depressants, General anaesthetics , Muscle relaxants , Azole Antifungal, HIV- protease inhibitors,  Guanethidine, Clonidine , Digoxin , Phenytoin , Itraconazole , Ketoconazole , Carbamazapine
Ref :-   Book : Martindale    Page : 457   Edition : 37.  

  ►    Mechanism of Drug Drug Interaction :  Trazodone should not be given to patients receiving MAOIs or for at least 14 days afterwards. It has also been recommended that any drug liable to provoke a serious reaction (e.g. phenelzine) should not be given within one week of stopping trazodone therapy. It is considered unlikely that trazodone will alter the effects of antihypertensives such as guanethidine; some interaction may, however, occur with clonidine. The dose of other antihypertensives may need to be reduced if used with trazodone. The sedative effects of trazodone may be enhanced by alcohol or other CNS depressants. The potential for interaction between trazodone and general anaesthetics or muscle relaxants exists and some licensed product information recommends that trazodone should be stopped before elective surgery for as long as clinically feasible. Trazodone may increase plasma concentrations of digoxin or phenytoin and some product information recommends monitoring their serum concentrations if used with trazodone. Trazodone is metabolised by the cytochrome P450 isoenzyme CYP3A4 and inhibitors of this isoenzyme may limit the elimination of trazodone. Consequently, trazodone may need to be given in reduced doses with drugs known to be potent inhibitors of CYP3A4 such as the azole antifungals itraconazole and ketoconazole, and the HIV-protease inhibitors. CYP3A4 inducers such as carbamazepine may reduce the plasma concentrations of trazodone.
Ref :-   Book : Martindale    Page : 457   Edition : 37.  

►  Contraindication : Trazodone should be used with caution in patients with cardiovascular disorders, such as ischaemic heart disease, and its use is not recommended in the immediate recovery phase after myocardial infarction. Similarly, it should be used with caution in patients with epilepsy and severe hepatic or renal impairment., Trazodone should be stopped immediately if patients develop signs of hepatic dysfunction or blood dyscrasias. Patients developing inappropriate or prolonged penile erections should also stop trazodone immediately., Drowsiness often occurs at the start of trazodone therapy and patients, if affected, should not drive or operate machinery
Ref :-   Book : Martindale    Page : 457   Edition : 37.  
  ►  Mechanism of Action :   It blocks the reuptake of serotonin at presynaptic neurones and has an action at 5-HT1 receptors. Trazodone is also an antagonist at 5-HT2A/2C receptors.
Ref :-   Book : Martindale    Page : 457   Edition : 37.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA

DIETARY Substance Interactions

​   ► This Medicine interact with :- NA

ContraIndication DIETARY Substance

​   ► This Medicine contraindicate with :- GINKGO BILOBA with cause coma .   GINKGO BILOBA with Causes serotonin syndrome ..  

  ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Williamson, E. (2009). Stockley's Herbal Medicines Interaction .. London: Pharmacutical press.

  •   ►  URL --

    ►   Route of Elimination :   Hepatic (Metabolism), Renal, Faecal
    Ref :-   Book : Martindale    Page : 457   Edition : 37.  

    ►    Plasma Half-life :   Min value :-   5 hours,    Max value :-   9 hours.  
    Ref :-   Book : Martindale    Page : 457   Edition : 37.  

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA