Trazodone is a Medicine belongs to Antidepressant group whose information about Brand can be referenced from   Book : Martindale    Page : 456   Edition : 37,

  ►   Brandname : Molipaxin,Desyrel

  ►  Strength : Tablet with 50  mg, Tablet with 100  mg, Tablet with 150  mg, Tablet with 300  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 539   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 456   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Depression Oral 150 mg Dose: Given daily.
2 Anxiety Oral 75 mg Dose: Given daily.

Ref :-  Book : Martindale    Page : 456   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Depression Oral 25 150 mg

Ref :- Book : Nelson's textbook of Pediatrics    Page : 63   Edition : 19,
►  Side Effect : drowsiness, Dizziness, headache, nausea, vomiting, weakness, weight loss, tremor, dry mouth, bradycardia, tachycardia, Orthostatic hypotension, oedema, constipation, diarrhea, Blurred Vision, Restlessness, Confusional states, insomnia, Skin rashes, agranulocytosis, thrombocytopenia, anaemia, jaundice, hepatocellular damage,
Ref :-   Book : Martindale    Page : 456   Edition : 37,

►  Drug Interaction : Drug interaction of Trazodone is with Acarbose , Zonisamide , Phentolamine , Testosterone , Tetracaine , Digoxin , Phenytoin , Itraconazole , Ketoconazole , Pioglitazone Hydrochloride , Carbamazapine ,
Ref :-   Book : Martindale    Page : 456.1   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Trazodone is metabolised by the cytochrome P450 isoenzyme CYP3A4 and inhibitors of this isoenzyme may limit the elimination of trazodone. Consequently, trazodone may need to be given in reduced doses with drugs known to be potent inhibitors of CYP3A4 such as the azole antifungals itraconazole and ketoconazole, and the HIV-protease inhibitors. CYP3A4 inducers such as carbamazepine may reduce the plasma concentrations of trazodone.,
Ref :-   Book : Martindale    Page : 456   Edition : 37,


►  Contraindication : hepatic dysfunction, blood dyscrasias,
Ref :-   Book : Martindale    Page : 456   Edition : 37,
  ►  Mechanism of Action :   Inhibition of 5-HT2A receptor ,
Ref :-   Book : Basic & Clinical pharmacology    Page : 538   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- GINKGO BILOBA with cause coma , GINKGO BILOBA with Causes serotonin syndrome .,

  ►  Reference :-
  • Williamson, E. (2009). Stockley's Herbal Medicines Interaction .. London: Pharmacutical press.
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf, http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 456   Edition : 37,


    ►    Plasma Half-life :   Min value :-   5 hours,    Max value :-   9 hours,
    Ref :-   Book : Martindale    Page : 456   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   1 hour,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 456   Edition : 37,