Tretinoin is a Medicine belongs to Retinoids / Dermatological drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1760   Edition : 37  

  ►   Brandname : Retin-A, ReTrieve, Eudyna, Retinova, Atralin, Avita, Renova, Airol, Cordes VAS
  ►  Strength : Cream with 0.02 %.  Cream with 0.025 %.  Cream with 0.05 %.  Cream with 0.1 %.  Gel with 0.01 %.  Gel with 0.025 %.  Gel with 0.04 %.  Solution with 0.05 %.  Solution with 0.1 %. 

Reference of this Medicine for its Strength can be taken from   Book : Goodman    Page : 1810   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Topical, Oral
Reference :-   Book : Martindale    Page : 1761   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Mottled hyperpigmentation, roughness, and fine wrinkling of photodamaged skin Topical 0.02 0.05 % Cream o.d. Applied daily at night
2 Remission in acute promyelocytic leukaemia Oral 45 mg/m2 Given in 2 divided doses with food

Ref :-  Book : Martindale    Page : 1761   Edition : 37  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Remission in acute promyelocytic leukaemia 1 Year 16 Year Oral 45 mg/m2

Ref :- Book : Martindale    Page : 1761   Edition : 37  
►  Side Effect : Topical application may cause transitory stinging and a feeling of warmth, and in normal use it produces some erythema, dryness, pruritus, and peeling similar to that of mild sunburn. Sensitive individuals may experience oedema, blistering, and crusting of the skin., Excessive application can cause severe erythema, peeling, and discomfort with no increase in efficacy. Photosensitivity may occur. Temporary hypopigmentation and hyperpigmentation have been reported., Oral doses of tretinoin may produce arrhythmias, flushing, hypotension, hypertension, and heart failure., Less common events were cardiac arrest, myocardial infarction, cardiomegaly, heart murmur, ischaemia, stroke, myocarditis, pericarditis, pulmonary hypertension, and secondary cardiomyopathy. A potentially life-threatening ‘retinoic acid syndrome’ has been described after oral use.
Ref :-   Book : Martindale    Page : 1760   Edition : 37.  

►  Drug Interaction : Drug interaction of Tretinoin is with , TETRACYCLINES ,  NA

  ►    Mechanism of Drug Drug Interaction :  Tretinoin is metabolised by the hepatic cytochrome P450 isoenzyme system, therefore there is a potential for interaction between oral tretinoin and inhibitors or inducers of these enzymes. Use of isotretinoin with vitamin A (including dietary supplements) should be avoided because of additive toxic effects. Tetracyclines should be avoided as their use with isotretinoin has been associated with the development of benign intracranial hypertension. Skin irritation may be increased if isotretinoin is given with topical keratolytic or exfoliative anti-acne treatments; such use should be avoided.
Ref :-   Book : Martindale    Page : 1743,1761   Edition : 37.  


►  Contraindication : Contact of tretinoin with the eyes, mouth, or other mucous surfaces should be avoided. It should not be applied to eczematous, sunburnt, or abraded skin and the effects of other topical treatment, especially with keratolytics, should be allowed to subside before topical use of tretinoin. , Exposure to UV light and excessive exposure to sunlight should be avoided., Oral tretinoin is contra-indicated in pregnancy and in breast-feeding mothers
Ref :-   Book : Martindale    Page : 1761   Edition : 37.  
  ►  Mechanism of Action :   Retinoic acid has several effects on epithelial tissues. It stabilizes lysosomes, increases ribonucleic acid polymerase activity, increases prostaglandin E 2 , cAMP, and cGMP levels, and increases the incorporation of thymidine into DNA. Its action in acne has been attributed to decreased cohesion between epidermal cells and increased epidermal cell turnover. This is thought to result in the expulsion of open comedones and the transformation of closed comedones into open ones.
Ref :-   Book : Basic & Clinical pharmacology    Page : 1069   Edition : 12.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Eucalyptus oil with Another pathway.  

  ►  Pathway with its reference as follows :-
  • Anti- acne . --- (GREESHMA, G. (2013). A REVIEW ON ANTI-ACNE POTENTIAL OF MEDICINAL PLANT EXTRACTS AGAINST PROPIONIBACTERIUM ACNES. International Journal Of Pharma And Bio Sciences, 3(3). )

  •   ►  URL --
  • file:///C:/Users/DR%20lounge/Downloads/111.pdf .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- VITAMIN A with Increase in Nutrient Level.  

      ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20


    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- VITAMIN A with Combining vitamin A with oral tretinoin is likely to increase the risk of side effects ..  

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf

    ►   Route of Elimination :   Biliary, Renal
    Ref :-   Book : Martindale    Page : 1761   Edition : 37.  

    ►    Plasma Half-life :   Min value :-   0.5 hours,    Max value :-   2 hours.  
    Ref :-   Book : Martindale    Page : 1761   Edition : 37.  

    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   2 hours.  
    Ref :-   Book : Martindale    Page : 1761   Edition : 37.