Triamterene is a Medicine belongs to Diuretic Agents group whose information about Brand can be referenced from   Book : Martindale    Page : 1556   Edition : 37,

  ►   Brandname : Dyranium,Dytac

  ►  Strength : Capsule with 50  mg, Capsule with 100  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 270   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 1556   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Oedema Oral 150 250 mg Dose: Given daily, given in 2 divided doses, after breakfast and lunch.
2 hypertension Oral 50 mg Dose: Given daily.

Ref :-  Book : Martindale    Page : 1556   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 hypertension 1 2 mg/kg/day b.d.
2 hypertension 1 2 mg/kg/day b.d.

Ref :- Book : Nelson's textbook of Pediatrics    Page : 1645   Edition : 19,
►  Organ Affected Nephrotoxicity –(Crystal nephropathy)  

Precaution :- If a Patient is using 'Triamterene' drug in acute kidney injury disease, then Please avoid using   if he ever suffered from chronic kidney disease disease.
►  Side Effect : photosensitivity reactions, increase in uric acid concentrations, blood dyscrasias, hyperkalaemia, nausea, vomiting, abdominal pain, diarrhea, constipation, paraesthesia, thirst, Dizziness, Skin rashes, pruritus, weakness, muscle cramps, headache, visual changes, Orthostatic hypotension, alopecia, Cough, dyspnoea, jaundice, encephalopathy, impotence, angina pectoris, Arrhythmias, palpitations,
Ref :-   Book : Martindale    Page : 1556, 1332   Edition : 37,

►  Drug Interaction : Drug interaction of Triamterene is with Sertraline, Ropivacaine , Cyclosporine , Tenecteplase ,
Ref :-   Book : Martindale    Page : 1332   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  NA


►  Absolute Contraindication : Acute renal failure   hyperkalemia   anuria.  

►  Contraindication : renal failure, hyperkalemia,
Ref :-   Book : Goodman    Page : 691   Edition : 12,
  ►  Mechanism of Action :   NA

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Cabbage with Another pathway, Lemon with Another pathway,

  ►  Pathway with its reference as follows :-
  • high water content NATURAL diuretic --- ( Drake, D. (1829). Medical and Physical Sciences. The Western Journal, 2. )
  • high water content NATURAL diuretic --- ( Rani, M. (2016). EFFECTIVENESS OF MINT JUICE VERSUS LEMON JUICE ON DYSMENORRHOEA. International Journal Of Recent Scientific Research, 7(4), 10707-10712. )

  •   ►  URL -- https://books.google.co.in/books?id=cthXAAAAMAAJ&pg=PA199&lpg=PA199&dq=cabbage+act+as+diuretic+journal&source=bl&ots=PE9EcB2F2o&sig=7u4eMxs-Q2O9DvtYv0CXlXKvE2k&hl=en&sa=X&ved=0ahUKEwj0mebXlqzOAhUMOI8KHZRRCbUQ6AEISjAJ#v=onepage&q=cabbage%20act%20as%20diuretic%20journal&f=false, http://www.recentscientific.com/sites/default/files/5162.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- IRON with Decrease in Nutrient Level, CALCIUM with Decrease in Nutrient Level, FOLIC ACID with Decrease in Nutrient Level, SODIUM with Decrease in Nutrient Level,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf, http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- FRANGULA I.E. RHAMNUS FRANGULA with frangula interact with carticosteroid ., MAGNESIUM with Triamterene may inhibit the urinary excretion of magnesium . , POTASSIUM with As a potassium -sparing drug , triamterene reduces urinary loss of potassium , which can lead to elevated potassium levels .,

      ►  Reference :-
  • Williamson, E. (2009). Stockley's Herbal Medicines Interaction .. London: Pharmacutical press.
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf, http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 1556   Edition : 37,


    ►    Plasma Half-life :   Min value :-   2 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1556   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : ,