Triamterene is a Medicine belongs to Diuretic Agents group whose information about Brand can be referenced from   Book : Martindale    Page : 1556   Edition : 37  

  ►   Brandname : Dytac, Dyrenium
  ►  Strength : Capsule with 50 mg.  Capsule with 100 mg. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 270   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 1556   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Oedema Oral 150 250 mg Dose: Given daily, given in 2 divided doses, after breakfast and lunch.
2 hypertension Oral 50 mg Dose: Given daily.

Ref :-  Book : Martindale    Page : 1556   Edition : 37  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 hypertension 1 2 mg/kg/day b.d.
2 hypertension 1 2 mg/kg/day b.d.

Ref :- Book : Nelson's textbook of Pediatrics    Page : 1645   Edition : 19  
Precaution :- If a Patient is using 'Triamterene' drug in acute kidney injury disease, then Please avoid using   if he ever suffered from chronic kidney disease disease.
►  Side Effect : Photosensitivity reactions, Renal calculi, Megaloblastic anaemia, Reversible renal failure, Hyperkalaemia, Nausea, Vomiting, Abdominal pain, Diarrhoea, Constipation, Paraesthesia, Thirst, Dizziness, Rashes, pruritus, Weakness, Muscle cramps, Headache, Minor psychiatric or visual changes, Orhtostatic hypotension raised in blood-urea-nitrogen concentrations , Alopecia, Cough, Dyspnoea, Jaundice, Encephalopathy, impotence, Angina pectoris, Arrhythmias, palpitations
Ref :-   Book : Martindale    Page : 1332,1556   Edition : 37.  

►  Drug Interaction : Drug interaction of Triamterene is with , Angiotensin conveting enzyme inhibitors , Angiotensin II Receptor Antagonist, NSAIDS, , Thiazide Diuretics ,  Trilostane, Carbenoxolone
Ref :-   Book : Martindale    Page : 1332, 1556   Edition : 37.  


  ►    Mechanism of Drug Drug Interaction :  There is an increased risk of hyperkalaemia if triametrene is given with potassium supplements or with other potassium-sparing diuretics. Hyperkalaemia may also occur in patients given triametrene with ACE inhibitors, angiotensin II receptor antagonists, NSAIDs, ciclosporin, or trilostane. In patients taking triametrene with NSAIDs or ciclosporin the risk of nephrotoxicity may also be increased. Diuretics may reduce the excretion of lithium and increase the risk of lithium toxicity, but this does not appear to occur with triametrene. Severe hyponatraemia may occur in patients taking a potassium- sparing diuretic with a thiazide; this risk may be increased in patients taking chlorpropamide. Triametrene may reduce the ulcer-healing properties of carbenoxolone. As with other diuretics, triametrene may enhance the effects of other antihypertensive drugs.
Ref :-   Book : Martindale    Page : 1332, 1556   Edition : 37.  


►  Contraindication : Triamterene should also be given with caution to patients with hyperuricaemia or gout, or a history of renal calculi. Patients with depleted folic acid stores such as those with hepatic cirrhosis may be at increased risk of megaloblastic anaemia.
Ref :-   Book : Martindale    Page : 1556   Edition : 37.  
  ►  Mechanism of Action :   Blocks epithelial sodium channels in collecting tubules
Ref :-   Book : Martindale    Page : 269   Edition : 12.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Cabbage with Another pathway.   Lemon with Another pathway.  

  ►  Pathway with its reference as follows :-
  • high water content NATURAL diuretic --- ( Drake, D. (1829). Medical and Physical Sciences. The Western Journal, 2. )
  • high water content NATURAL diuretic --- ( Rani, M. (2016). EFFECTIVENESS OF MINT JUICE VERSUS LEMON JUICE ON DYSMENORRHOEA. International Journal Of Recent Scientific Research, 7(4), 10707-10712. )

  •   ►  URL --
  • https://books.google.co.in/books?id=cthXAAAAMAAJ&pg=PA199&lpg=PA199&dq=cabbage+act+as+diuretic+journal&source=bl&ots=PE9EcB2F2o&sig=7u4eMxs-Q2O9DvtYv0CXlXKvE2k&hl=en&sa=X&ved=0ahUKEwj0mebXlqzOAhUMOI8KHZRRCbUQ6AEISjAJ#v=onepage&q=cabbage%20act%20as%20diuretic%20journal&f=false .
  • http://www.recentscientific.com/sites/default/files/5162.pdf .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- IRON with Decrease in Nutrient Level.   CALCIUM with Decrease in Nutrient Level.   FOLIC ACID with Decrease in Nutrient Level.   SODIUM with Decrease in Nutrient Level.  

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf
    http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf


    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- FRANGULA I.E. RHAMNUS FRANGULA with frangula interact with carticosteroid ..   MAGNESIUM with Triamterene may inhibit the urinary excretion of magnesium . .   POTASSIUM with As a potassium -sparing drug , triamterene reduces urinary loss of potassium , which can lead to elevated potassium levels ..  

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Williamson, E. (2009). Stockley's Herbal Medicines Interaction .. London: Pharmacutical press.

  •   ►  URL -- https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf
    http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf

    ►   Route of Elimination :   Renal
    Ref :-   Book : Martindale    Page : 1556   Edition : 37.  

    ►    Plasma Half-life :   Min value :-   2 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1556   Edition : 37.  

    ►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : .