Triazolam is a Medicine belongs to Benzodiazepine group whose information about Brand can be referenced from   Book : Martindale    Page : 1141   Edition : 37,

  ►   Brandname : Halcion

  ►  Strength : Tablet with 0.125  mg, Tablet with 0.25  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 387   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 1141   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Insomnia Oral 125 250 mcg Tablet Dose: Given at night.

Ref :-  Book : Martindale    Page : 1140   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : drowsiness, Sedation, muscle weakness, ataxia, vertigo, headache, Confusion, Depression, slurred speech, dysarthria, changes in libido, tremor, visual disturbances, urinary retention, urinary incontinence, gastrointestinal disturbance, changes in salivation, amnesia, jaundice, blood disorder, hypersensitivity reactions, extrapyramidal disorders, cholestasis, severe pruritus with jaundice,
Ref :-   Book : Martindale    Page : 1090   Edition : 37,

►  Drug Interaction : Drug interaction of Triazolam is with Zonisamide , Propafenone Hydrochloride , , Testosterone , Baclofen , Ethinylestradiol , Abatacept , Ropinirole , Carbamazapine , Phenobarbital , Mivacurium Chloride , Clozapine , Sildenafil , Phenytoin ,
Ref :-   Book : Martindale    Page : 1093   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Enhanced sedation or respiratory and cardiovascular depression may occur if diazepam or other benzodiazepines are given with other drugs that have CNS depressant properties; these include alcohol, antidepressants sedative antihistamines, antipsychotics, general anaesthetics, other hypnotics or sedatives, and opioid analgesics. The metabolism of most benzodiazepines is mediated primarily by the cytochrome P450 system, particularly the isoenzyme CYP2C19 and CYP3A4. Hence, adverse effect may also be produced by use with drugs that inhibit or induce oe are metabolised by use with drugs that inhibit or induce or are metabolised by these enzyme. Carbamazepine, phenobarbital, and phenytoin are all inducers of hepatic drug-metabolising enzymes. Therefore, in patients receiving long-term therapy with these dru,
Ref :-   Book : Martindale    Page : 1093   Edition : 37,


►  Contraindication : CNS depression, coma, respiratory depression, acute pulmonary insufficiency, myasthenia gravis, sleep apnea, muscle weakness,
Ref :-   Book : Martindale    Page : 1092   Edition : 37,
  ►  Mechanism of Action :   Bind to specific GABAA receptor subunits at CNS neuronal synapses facilitating frequency of GABA- mediated chloride ion channel opening-enhance membrane hyperpolarization.,
Ref :-   Book : Basic & Clinical pharmacology    Page : 386   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Kava kava with Another pathway,

  ►  Pathway with its reference as follows :-
  • Kava Kava act as CNS depressants . --- (Chua, H., Christensen, E., Hoestgaard-Jensen, K., Hartiadi, L., Ramzan, I., & Jensen, A. et al. (2016). Kavain, the Major Constituent of the Anxiolytic Kava Extract, Potentiates GABAA Receptors: Functional Characteristics and Molecular Mechanism. PLOS ONE, 11(6), e0157700. http://dx.doi.org/10.1371/journal.pone.0157700 )

  •   ►  URL -- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917254/,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- MELATONIN with Taking melatonin and triazolam together produces better quality of sleep than occurs when the drug is taken alone .,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 1141   Edition : 37,


    ►    Plasma Half-life :   Min value :-   1.5 hours,    Max value :-   5.5 hours,
    Ref :-   Book : Martindale    Page : 1147   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1147   Edition : 37,