Triazolam is a Medicine belongs to Sedatives- hypnotics group whose information about Brand can be referenced from   Book : Martindale    Page : 1141   Edition : 37  

  ►   Brandname : Halcion
  ►  Strength : Tablet with 0.125 mg.  Tablet with 0.25 mg. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 387   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 1141   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Insomnia Oral 125 250 mcg Tablet Dose: Given at night; doses of up to 500 micrograms at night have been used for resistant cases but these may be associated with an increased risk of severe adverse effects. Initial doses of 125 micrograms at night have been suggested for elderly or debilitated subjects, increased up to a maximum of 250 micrograms only if necessary.

Ref :-  Book : Martindale    Page : 1140   Edition : 37  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :    Page :    Edition :   
►  Side Effect : Drowsiness, Sedation, Muscle weakness, Ataxia, Vertigo, Headache, Confusion, Depression, Slurred speech, Dysarthria, Changes in libido, Tremor, Visual disturbances, Urinary retention, Urinary incontinence, Gastrointestinal disturbance, Changes in salivation, Amnesia, Paradoxical excitation
Ref :-   Book : Martindale    Page : 1090,1140   Edition : 37.  

►  Drug Interaction : Drug interaction of Triazolam is with Alcohol, antidepressants, Antipsychotics, General anaesthetics , , opioid analgesics, Sedative antihistamines,  NA

  ►    Mechanism of Drug Drug Interaction :  Enhanced sedation or respiratory and cardiovascular depression may occur if diazepam or other benzodiazepines are given with other drugs that have CNS depressant properties; these include alcohol, antidepressants, sedative antihistamines, antipsychotics, general anaesthetics, other hypnotics or sedatives, and opioid analgesics. The metabolism of most banzodiazipines is mediated primarily by the cytochrome P450 system, particularly the isoenzymes CYP2C19 and CYP3A4. Hence, adverse effects may also be produce by use with drugs that inhibit or induce or metabolized by these isoenzymes. Benzodiazepines such as diazepam that are metabolised primarily by hepatic microsomal oxidation may be more susceptible to pharmacokinetic changes than those eliminated primarily by glucuronide conjugation.
Ref :-   Book : Martindale    Page : 1093,1141   Edition : 37.  

►  Contraindication : Hepatic impairment, Myasthenia gravis, Pre-existing CNS depression or coma, Respiratory depression, Acute pulmonary insufficiency, Renal impairment, Sleep apnoea, Chronic pulmonary insufficiency, Triazolam is not appropriate for the treatment of chronic psychosis or for phobic or obsessional states, Caution is required in patients with organic brain changes particularly arteriosclerosis
Ref :-   Book : Martindale    Page : 1092,1140   Edition : 37.  
  ►  Mechanism of Action :   Bind to specific GABAA receptor subunits at CNS neuronal synapses facilitating frequency of GABA- mediated chloride ion channel opening-enhance membrane hyperpolarization.
Ref :-   Book : Basic & Clinical pharmacology    Page : 386   Edition : 12.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- Kava kava with Another pathway.  

  ►  Pathway with its reference as follows :-
  • Kava Kava act as CNS depressants . --- (Chua, H., Christensen, E., Hoestgaard-Jensen, K., Hartiadi, L., Ramzan, I., & Jensen, A. et al. (2016). Kavain, the Major Constituent of the Anxiolytic Kava Extract, Potentiates GABAA Receptors: Functional Characteristics and Molecular Mechanism. PLOS ONE, 11(6), e0157700. )

  •   ►  URL --
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  • DIETARY Substance Interactions

    ​   ► This Medicine interact with :- NA

    ContraIndication DIETARY Substance

    ​   ► This Medicine contraindicate with :- MELATONIN with Taking melatonin and triazolam together produces better quality of sleep than occurs when the drug is taken alone ..  

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL --

    ►   Route of Elimination :   Renal
    Ref :-   Book : Martindale    Page : 1141   Edition : 37.  

    ►    Plasma Half-life :   Min value :-   1.5 hours,    Max value :-   5.5 hours.  
    Ref :-   Book : Martindale    Page : 1147   Edition : 37.  

    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1147   Edition : 37.