Trifluridine is a Medicine belongs to Antiviral group whose information about Brand can be referenced from   Book : Martindale    Page : 1020   Edition : 38  

  ►   Brandname : Viroptic
  ►  Strength : Ophthalmic Solution with 1 %. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 889   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : ophthalmic
Reference :-   Book : Martindale    Page : 1020   Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Primary keratoconjunctivitis and recurrent epithelial keratitis due to herpes simplex viruses ophthalmic 1 % Ophthalmic Solution Ophthalmic solution instilled into the eye every 2 hours up to a maximum of 9 times daily until complete re-epithelialisation has occurred. Treatment is then reduced to one drop every 4 hours to a minimum of 5 drops daily for a further 7 days. Treatment should not be continued for more than a total of 21 days.

Ref :-  Book : Martindale    Page : 1020   Edition : 38  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1

Ref :- Book :    Page :    Edition :   
►  Side Effect : Irritation, Pain, pruritus, Stinging, Conjunctivitis, Oedema, Inflammation of the eye or eyelids, Photophobia
Ref :-   Book : Martindale    Page : 985   Edition : 38.  

►  Drug Interaction : Drug interaction of Trifluridine is with NA

  ►    Mechanism of Drug Drug Interaction :  N.F.R.B
Ref :-   Book :    Page :    Edition : .  


►  Contraindication :
Ref :-   Book :    Page :    Edition : .  
  ►  Mechanism of Action :   Trifluridine (trifluorothymidine) is a fluorinated pyrimidine nucleoside that inhibits viral DNA synthesis in HSV-1, HSV-2, CMV, vaccinia, and some adenoviruses
Ref :-   Book : Basic & Clinical pharmacology    Page : 866   Edition : 12.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Garlic with Another pathway.   Alpine cranberry with Another pathway.  

  ►  Pathway with its reference as follows :-
  • Acylphloroglucinols have Anti-viral effect --- (AB, H. (2010). Antiviral effects of cranberry juice and cranberry proanthocyanidins on foodborne viral surrogates--a time dependence study in vitro. Food Microbiol., 27(8). http://dx.doi.org/10.1016/j.fm.2010.05.027 )
  • Anti-viral effect --- (Antiviral Properties of Garlic Cloves Juice Compared with Onion Bulbs Juice Against Potato Virus Y (PVY). (2016). Journal Of American Science, 6(8). )

  •   ►  URL --
  • http://www.jofamericanscience.org/journals/am-sci/am0608/39_2830_am0608_302_310.pdf .
  • http://www.ncbi.nlm.nih.gov/pubmed/20832675 .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   NA

    ►    Plasma Half-life :   Min value :-   NA    Max value :-   NA

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA