Trihexyphenidyl (Benzhexol) is a Medicine belongs to Antiparkinsonian Drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 918   Edition : 38,

  ►   Brandname : Barohexy,Bexol,Trihexy,Artane

  ►  Strength : Tablet with 2  mg, Tablet with 5  mg, Elixir with 2  mg/5mL, Sustained-release capsules with 5  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 498   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 917   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Parkinson’s disease Oral 1 20 mg Tablet Dose given daily and is gradually increased at intervals of 3 to 5 days by increments of 2 mg to 6 to 10 mg daily according to response; for advanced cases, 12 to 15 mg daily or even more (up to 20 mg daily) may be needed.
2 Drug-induced extrapyramidal symptoms Oral Tablet Usual doses for drug-induced extrapyramidal symptoms lie within the range of 5 to 15 mg daily, although as little as 1 mg daily may be sufficient in some cases.

Ref :-  Book : Martindale    Page : 917   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : In some patients, such as those with arteriosclerosis or a history of drug idiosyncrasy, trihexyphenidyl may produce mental disturbances, excitement, or nausea and vomiting, Tardive dyskinesia,
Ref :-   Book : Martindale    Page : 918   Edition : 38,

►  Drug Interaction : Drug interaction of Trihexyphenidyl (Benzhexol) is with , Phenothiazine antipsychotics, Tricyclic antidepressants, Monoamine Oxidase Inhibitors, Parasympathomimetics,  Amantadine , Cisapride , Domperidone , Metoclopramide ,
Ref :-   Book : Martindale    Page : 918,1312   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  The effects of atropine and other antimuscarinics may be enhanced by use with other drugs having antimuscarinic properties, such as amantadine, some antihistamines, phenothiazine antipsychotics, and tricyclic antidepressants. Inhibition of drug-metabolising enzymes by MAOIs may possibly enhance the effects of antimuscarinics. The reduction in gastric motility caused by antimuscarinics may affect the absorption of other drugs. Antimuscarinics may also antagonise the gastrointestinal effects of cisapride, domperidone, and metoclopramide. Antimuscarinics and parasympathomimetics may counteract each others effects.,
Ref :-   Book : Martindale    Page : 918,1312   Edition : 38,


►  Contraindication : If a severe reaction occurs, trihexyphenidyl should be stopped for a few days and resumed at a lower dose,
Ref :-   Book : Martindale    Page : 918   Edition : 38,
  ►  Mechanism of Action :   Antagonist at muscarinic receptors in basal ganglia.,
Ref :-   Book : Basic & Clinical pharmacology    Page : 498   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   NA


►    Plasma Half-life :
  Min value :-   NA    Max value :-   NA


►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA