Trilostane is a Medicine belongs to Miscellaneous Drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 2642   Edition : 37  

  ►   Brandname : Modrenal
  ►  Strength : Capsule with

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 2642   Edition : 37  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 2642   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Adrenal cortical hyperfunction Oral 240 mg Dose: Given in divided doses for at least 3 days and then adjusted, according to response, within the range of 120 to 480 mg daily. Doses of 960 mg daily have been given.
2 Postmenopausal breast cancer Oral 240 mg Dose: given in divided doses, with glucocorticoid replacement therapy. This is increased in steps of 240 mg every 3 days up to a maintenance dose of 960 mg daily; this may be reduced to 720 mg daily if adverse effects are intolerable

Ref :-  Book : Martindale    Page : 2642   Edition : 37  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1

Ref :- Book :    Page :    Edition :   
►  Side Effect : Flushing, Nausea, Vomiting, Diarrhoea, Rhinorrhoea, Tingling and swelling of the mouth, Rashes
Ref :-   Book : Martindale    Page : 2642   Edition : 37.  

►  Drug Interaction : Drug interaction of Trilostane is with Oral Contraceptive, Potassium -Sparing Diuretics , ALDOSTERONE ANTAGONISTS ,  NA

  ►    Mechanism of Drug Drug Interaction :  Trilostane may interfere with the activity of oral contraceptives. Hyperkalaemia may occur if trilostane is given with potassiumsparing diuretics or aldosterone antagonists.
Ref :-   Book : Martindale    Page : 2642   Edition : 37.  


►  Contraindication : Pregnancy, Hepatic impairment, Renal impairment
Ref :-   Book : Martindale    Page : 2642   Edition : 37.  
  ►  Mechanism of Action :   Trilostane is an adrenocortical suppressant that inhibits the enzyme system essential for the production of glucocorticoids and mineralocorticoids.
Ref :-   Book : Martindale    Page : 2642   Edition : 37.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


DIETARY Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication DIETARY Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   NA

►    Plasma Half-life :   Min value :-   NA    Max value :-   NA

►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA