Trimethobenzamide is a Medicine belongs to Antiemetic group whose information about Brand can be referenced from   Book : Martindale    Page : 642   Edition : 38,

  ►   Brandname : Ticon,Tigan

  ►  Strength : Capsule with 250  mg, Capsule with 300  mg, Injection with 100  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 1112   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IM,
Reference :-   Book : Martindale    Page : 662   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Antiemetic in the control of nausea and vomiting including postoperative nausea and vomiting Oral 300 mg Capsule t.i.d/q.i.d
2 Antiemetic in the control of nausea and vomiting including postoperative nausea and vomiting IM 200 mg Injection t.i.d/q.i.d

Ref :-  Book : Martindale    Page : 642   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Pain at the site of intramuscular injection, Restlessness, dystonia, local irritation after rectal use, parkinsonian symptoms,
Ref :-   Book : Martindale    Page : 642   Edition : 38,

►  Drug Interaction : Drug interaction of Trimethobenzamide is with Phentolamine , Zonisamide , Norgestrienone , Norgestrel , Ethinylestradiol , Bezafibrate , , Corticotropin , Atropine , Zaleplon ,
Ref :-   Book : Martindale    Page : 614   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Sedating antihistamines may enhance the sedative effects of CNS depressants including alcohol, barbiturates, hypnotics, opioid analgesics, anxiolytic sedatives, and antipsychotics. Sedating antihistamines have an additive antimuscarinic action with other antimuscarinic drugs, such as atropine and some antidepressants (both tricyclics and MAOIs). Some sedating antihistamines could mask the warning signs of damage caused by ototoxic drugs such as aminoglycoside antibiotics. Antihistamines may suppress the cutaneous histamine response to allergen extracts and should be stopped several days before skin testing. ,
Ref :-   Book : Martindale    Page : 614   Edition : 37,


►  Contraindication : not drive, Alcohol, premature infants, , operate machinery,
Ref :-   Book : Martindale    Page : 613,614   Edition : 38,
  ►  Mechanism of Action :   Primary mechanism of antiemetic action is believed to be dopamine-receptor blockade. Trimethobenzamide also has weak antihistaminic activity,
Ref :-   Book : Basic & Clinical pharmacology    Page : 1100   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal,
Ref :-   Book : Martindale    Page : 642   Edition : 38,


►    Plasma Half-life :
  Min value :-   7 hours,    Max value :-   9 hours,
Ref :-   Book : Martindale    Page : 642   Edition : 38,

►    Peak Plasma Concentration :   Min value :-   0.75,    Max value :-   NA
Ref :-   Book : Martindale    Page : 642   Edition : 38,