Trimethobenzamide is a Medicine belongs to Antiemetic group whose information about Brand can be referenced from   Book : Martindale    Page : 644   Edition : 37  

  ►   Brandname : Ticon; T-Gen; Tebamide, Tigan
  ►  Strength : Capsule with 250 mg.  Capsule with 300 mg.  Injection with 100 mg/ml. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 1112   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IM
Reference :-   Book : Martindale    Page : 644   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Antiemetic in the control of nausea and vomiting including postoperative nausea and vomiting Oral 300 mg Capsule t.i.d/q.i.d
2 Antiemetic in the control of nausea and vomiting including postoperative nausea and vomiting IM 200 mg Injection t.i.d/q.i.d

Ref :-  Book : Martindale    Page : 644   Edition : 37  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1

Ref :- Book :    Page :    Edition :   
►  Side Effect : CNS depression, Slight drowsiness to deep sleep, Lassitude, Dizziness, Incoordination, Headache, Psychomotor impairment, Dry mouth, Thickened respiratory-tract secretions, Blurred Vision, Urinary difficulty or retention, Constipation, Increased gastric reflux, Convulsion, Sweating, Myalgia, Paraesthesia, Extrapyramidal effects, Tremor, Sleep disturbances, Depression, Confusion, Tinnitus, Hypotension, Hair loss, Nausea, Vomiting, Diarrhoea, Epigastric pain, Hypersensitivity reactions, Bronchospasm, Angioedema, Anaphylaxis
Ref :-   Book : Martindale    Page : 611, 644   Edition : 37.  

►  Drug Interaction : Drug interaction of Trimethobenzamide is with Alcohol, Barbiturates , Hypnotics, opioid analgesics, Anxiolytic sedatives, Antipsychotic , ,  Atropine
Ref :-   Book : Martindale    Page : 613, 644   Edition : 37.  


  ►    Mechanism of Drug Drug Interaction :  Sedating antihistamines may enhance the sedative effects of CNS depressants including alcohol, barbiturates, hypnotics, opioid analgesics, anxiolytic sedatives, and antipsychotics. Sedating antihistamines have an additive antimuscarinic action with other antimuscarinic drugs, such as atropine and some antidepressants (both tricyclics and MAOIs)
Ref :-   Book : Martindale    Page : 613,644   Edition : 37.  


►  Contraindication : Urinary retention, Drowsiness is a major problem with the sedating antihistamines and those affected should not drive or operate machinery; alcohol should be avoided, Angle-closure glaucoma, prostatic hyperplasia, Pyloroduodenal obstruction, Renal impairment
Ref :-   Book : Martindale    Page : 612, 644   Edition : 37.  
  ►  Mechanism of Action :   Primary mechanism of antiemetic action is believed to be dopamine-receptor blockade. Trimethobenzamide also has weak antihistaminic activity
Ref :-   Book : Basic & Clinical pharmacology    Page : 1100   Edition : 12.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


DIETARY Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication DIETARY Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal
Ref :-   Book : Martindale    Page : 644   Edition : 37.  

►    Plasma Half-life :   Min value :-   7 hours,    Max value :-   9 hours.  
Ref :-   Book : Martindale    Page : 644   Edition : 37.  

►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA