Trimethoprim is a Medicine belongs to Diaminopyrimidines group whose information about Brand can be referenced from   Book : Martindale    Page : 383   Edition : 38,

  ►   Brandname : Monotrim,Proloprim,Trimpex

  ►  Strength : Tablet with 100  mg, Tablet with 200  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 837   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV,
Reference :-   Book : Martindale    Page : 381   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info

Ref :-  Book :




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Skin rashes, anorexia, nausea, vomiting, abdominal pain, diarrhea, megaloblastic anaemia, leucopenia, granulocytopenia,
Ref :-   Book : Basic & Clinical pharmacology    Page : 834   Edition : 12,

►  Drug Interaction : Drug interaction of Trimethoprim is with Phenytoin , Digoxin , Procainamide , Rosiglitazone , Repaglinide , Zidovudine, Zalcitabine, Lamivudine, Dapsone , Cyclosporine , Tenecteplase , Pyrimethamine , Methotrexate, Sertraline,
Ref :-   Book : Martindale    Page : 382   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Trimethoprim may increase serum concentrations and potentiate the effect of a number of drugs, including phenytoin, digoxin, procainamide, rosiglitazone, and repaglinide. This may be due to competitive inhibition of renal excretion, decreased metabolism, or both. It has been suggested that trimethoprim may potentiate the effects of warfarin. Trimethoprim has been reported to reduce the renal excretion and increase blood concentrations of zidovudine, zalcitabine, and lamivudine. Trimethoprim and dapsone increase each other’s serum concentrations, whereas rifampicin may decrease trimethoprim concentrations. An increased risk of nephrotoxicity has been reported with the use of trimethoprim or co-trimoxazole and ciclosporin. Intravenous use of trimethoprim and sulfonamides may reduce ciclosporin concentrations in blood. Hyponatraemia has been reported in patients given trimethoprim with diuretics.Severe hyperkalaemia has been noted in patients given trimethoprim (or co-trimoxazole) together with an ACE inhibitor. There may be a particular risk of megaloblastic anaemia if it is given with other folate inhibitors, such as pyrimethamine or methotrexate,
Ref :-   Book : Martindale    Page : 382   Edition : 38,


►  Contraindication : Hypersensitivity, haematological disorders,
Ref :-   Book : Martindale    Page : 382   Edition : 38,
  ►  Mechanism of Action :   Trimethoprim, a trimethoxybenzylpyrimidine, selectively inhibits bacterial dihydrofolic acid reductase, which converts dihydrofolic acid to tetrahydrofolic acid, a step leading to the synthesis of purines and ultimately to DNA.,
Ref :-   Book : Basic & Clinical pharmacology    Page : 833   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Tulsi with Another pathway,

  ►  Pathway with its reference as follows :-
  • --- (Duke, J. (2002). Hand Book Of Medicinal Herbs (2nd ed.). United States Of America: CRC Press. )

  •   ►  URL -- https://www.crcpress.com/Handbook-of-Medicinal-Herbs-Second-Edition/Duke/p/book/9780849312847,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- CALCIUM with Decrease in Nutrient Level, FOLIC ACID with Decrease in Nutrient Level, MAGNESIUM with Decrease in Nutrient Level, VITAMIN B12 with Decrease in Nutrient Level, VITAMIN B6 with Decrease in Nutrient Level, VITAMIN K with Decrease in Nutrient Level, FOLATE with Decrease in Nutrient Level,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • YAHEYA, MOHAMMAD. "DRUG-FOOD INTERACTIONS AND ROLE OF PHARMACIST". Asian Journal of Pharmaceutical and Clinical Research 2.4 (2009): n. pag. Print.

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf, http://ajpcr.com/Vol2Issue4/226.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 387   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   8 hours,    Max value :-   10 hours,
    Ref :-   Book : Martindale    Page : 387   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   1 hour,    Max value :-   4 hours,
    Ref :-   Book : Martindale    Page : 387   Edition : 37,