Trimipramine is a Medicine belongs to Antidepressant group whose information about Brand can be referenced from   Book : Martindale    Page : 458   Edition : 37,

  ►   Brandname : Surmontil

  ►  Strength : Capsule with 25  mg, Capsule with 50  mg, Capsule with 100  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 539   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 458   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Depression Oral 25 mg Tablet Dose: Given daily.

Ref :-  Book : Martindale    Page : 458   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Depression Oral 50 mg Tablet

Ref :- Book : Martindale    Page : 458   Edition : 37,
►  Side Effect : NA

►  Drug Interaction : Drug interaction of Trimipramine is with Acarbose , Phenobarbital , Zonisamide , Bevacizumab , Clopamide , Tyramine, Cimetidine , Methylphenidate , , Suxamethonium/Succinylcholinechloride (Suxamethonium chloride) , Guanethidine, Clonidine , Amiodarone , Cisapride , Sotalol , Fluconazole ,
Ref :-   Book : Martindale    Page : 458.1   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Drugs that inhibit or induce the cytochrome P450 isoenzyme CYP2D6 may affect tricyclic metabolism and produce marked alterations in plasma concentrations. Adverse effects may be enhanced by antimuscarinic drugs or CNS depressants, including alcohol. Barbiturates and other enzyme inducers such as rifampicin and some antiepileptics can increase the metabolism of tricyclic antidepressants and may lower plasma concentrations and reduce antidepressant response ,
Ref :-   Book : Martindale    Page : 458   Edition : 37,


►  Contraindication : Porphyria,
Ref :-   Book : Martindale    Page : 458   Edition : 37,
  ►  Mechanism of Action :   inhibit the neuronal reuptake of noradrenaline in the CNS; some, in addition, inhibit the reuptake of serotonin (5-HT),
Ref :-   Book : Martindale    Page : 458   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal,
Ref :-   Book : Martindale    Page : 458   Edition : 37,


►    Plasma Half-life :
  Min value :-   23 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 458   Edition : 37,

►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 458   Edition : 37,