Trioxysalen/Trimethyl psoralen is a Medicine belongs to Dermatological drug group whose information about Brand can be referenced from   Book : Martindale    Page : 1727   Edition : 38,

  ►   Brandname : Dsorolen,Dermtone,Tripsor,Trisoralen

  ►  Strength : Capsule with NF  ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page :    Edition : ,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, Topical,
Reference :-   Book : Goodman    Page : 1813   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Vitiligo Oral 20 mg up to 600 micrograms/kg
2 Vitiligo Topical 1 % Cream
3 Psoriasis Oral 600 micrograms/kg
4 Psoriasis Topical 0.15 % Cream

Ref :-  Book : Martindale    Page : 1712   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : nausea, insomnia, Nervousness, Depression, pruritus, mild transient erythema, oedema, Dizziness, headache, vesiculation, bulla formation, acneform eruption, severe skin pain, severe burns, hypertrichosis, pigmentation alterations of skin or nails, Onycholysis, premature ageing of the skin, malignant cutaneous neoplasms,
Ref :-   Book : Martindale    Page : 1746   Edition : 37,

►  Drug Interaction : Drug interaction of Trioxysalen/Trimethyl psoralen is with NA

  ►    Mechanism of Drug Drug Interaction :  Methoxsalen should be used with caution with other drugs also known to cause photosensitivity. It inhibits the action of cytochrome P450 isoenzyme CYP2A6, and may increase plasma concentrations of drugs metabolised via this enzyme.,
Ref :-   Book : Martindale    Page : 1747   Edition : 37,


►  Contraindication : aphakia, myeloma, Invasive squamous cell carcinoma,
Ref :-   Book : Martindale    Page : 1747   Edition : 37,
  ►  Mechanism of Action :   The action spectrum for oral PUVA is between 320 and 340 nm. Two distinct photoreactions take place. Type I reactions involve the oxygen-independent photoaddition of psoralens to pyrimidine bases in DNA. Type II reactions are oxygen dependent and involve the transfer of energy to molecular oxygen, creating reactive oxygen species,
Ref :-   Book : Goodman    Page : 1813   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   NA


►    Plasma Half-life :
  Min value :-   NA    Max value :-   NA


►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA