Tubocurarine Chloride is a Medicine belongs to Neuromuscular blocker group whose information about Brand can be referenced from   Book : Martindale    Page : 2076   Edition : 37  

  ►   Brandname : Curarine, Tubarine, Decurin
  ►  Strength : Injection with 3 mg/ml. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 481   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV
Reference :-   Book : Basic & Clinical pharmacology    Page : 481   Edition : 12  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Anaesthesia IV 0.1 0.4 mg/kg Injection Dose: initially causes motor weakness, followed by the skeletal muscles becoming flaccid and inexcitable to electrical stimulation

Ref :-  Book : Basic & Clinical pharmacology    Page : 473   Edition : 12  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1

Ref :- Book :    Page :    Edition :   
►  Side Effect : Tachycardia and a rise in blood pressure, Reduction in blood pressure with compensatory tachycardia, Reduces gastrointestinal motility, Histamine release may also lead to wheal-and-flare effects at the site of injection, flushing, occasionally bronchospasm
Ref :-   Book : Martindale    Page : 2066,2076   Edition : 37.  

►  Drug Interaction : Drug interaction of Tubocurarine Chloride is with NA

  ►    Mechanism of Drug Drug Interaction :  Some drugs may influence neuromuscular transmission and thus interfere with the action of both competitive and depolarising neuromuscular blockers, resulting in potentiation or antagonism of neuromuscular block. Some interactions may be advantageous, such as the reversal of competitive neuromuscular block by anticholinesterases. In general, adverse interactions are potentially more serious in patients with impaired neuromuscular function.
Ref :-   Book : Martindale    Page : 2066,2076   Edition : 37.  


►  Contraindication : Hepatic impairment, Renal impairment, Caution is also needed in patients with a history of conditions such as asthma where release of histamine would be a hazard., Care is also required in patients with a history of hypersensitivity to any neuromuscular blocker because high rates of cross-sensitivity have been reported.
Ref :-   Book : Martindale    Page : 2066,2076   Edition : 37.  
  ►  Mechanism of Action :   Tubocurarine is a benzylisoquinolinium competitive neuromuscular blocker. It act by competing with acetylcholine for receptors on the motor end-plate of the neuromuscular junction to produce blockade.
Ref :-   Book : Martindale    Page : 2069,2076   Edition : 37.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


DIETARY Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication DIETARY Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal
Ref :-   Book : Basic & Clinical pharmacology    Page : 40   Edition : 12.  

►    Plasma Half-life :   Min value :-   2 hours,    Max value :-   NA
Ref :-   Book : Basic & Clinical pharmacology    Page : 40   Edition : 12.  

►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
Ref :-   Book :    Page :    Edition : .