Urokinase is a Medicine belongs to Fibrinolytic Drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1558   Edition : 37,

  ►   Brandname : Solokinase,Ukidan,Syner-Kinase,Abbokinase

  ►  Strength : Injection with 250000  IU,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 617   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV,
Reference :-   Book : Martindale    Page : 1558   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Venous thromboembolism IV infusion 4400 units/kg Injection over 10 to 20 min.
2 Peripheral arterial thromboembolism IV 2000 units/ml Injection

Ref :-  Book : Martindale    Page : 1521   Edition : 38, Martindale    Page : 1521   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Clear occluded catheters IV Injection

Ref :- Book : Martindale    Page : 1558   Edition : 37,
►  Side Effect : Haemorrhage, Rashes, bradycardia, fever, Arrhythmias, Acute renal failure, pulmonary embolism, back pain, uveitis, iritis, transient proteinura, vasculitis, raised liver enzymes,
Ref :-   Book : Martindale    Page : 1539, 1558   Edition : 37,

►  Drug Interaction : Drug interaction of Urokinase is with Heparin , Aspirin (Acetylsalicylic acid), Dextran, Ropinirole ,
Ref :-   Book : Martindale    Page : 1541   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Oral anticoagulants, heparin, and antiplatelet drugs such as aspirin are often used with streptokinase, but may increase the risk of haemorrhage. The risk may also be increased with dextrans, and with other drugs that affect coagulation or platelet function,
Ref :-   Book : Martindale    Page : 1541   Edition : 37,


►  Contraindication : peptic ulcer disease, oesophageal varices, ulcerative colitis , bleeding gastrointestinal lesions, pancreatitis, cerebral bleeding, Severe hypotension, Haemorrhagic disorder, Cerebral neoplasm, pregnancy,
Ref :-   Book : Martindale    Page : 1539   Edition : 37,
  ►  Mechanism of Action :   Streptokinase is a thrombolytic drug derived from various streptococci. It rapidly activates endogenous plasminogen, indirectly by means of a streptokinase-plasminogen complex, to plasmin which has fibrinolytic effects and can dissolve intravascular blood clots,
Ref :-   Book : Martindale    Page : 1541   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Garlic with Another pathway,

  ►  Pathway with its reference as follows :-
  • It used to dissolves unwanted blood clots. --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Hepatic (Metabolism),
    Ref :-   Book : Martindale    Page : 1558   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   0.33 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1558   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : ,