Ursodeoxycholic acid is a Medicine belongs to Gall stone dissolving agents group whose information about Brand can be referenced from   Book : Martindale    Page : 2647   Edition : 37  

  ►   Brandname : Udiliv, Destolit, Urdox, Ursofalk, Ursogal, Actigall, Urso
  ►  Strength : Tablet with 250 mg.  Tablet with 500 mg.  Capsule with 300 mg. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 1112   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 2646   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Gallstones Oral 6 12 mg/kg h.s.
2 Primary biliary cirrhosis Oral 10 16 mg/kg Daily in 2 to 4 divided doses.

Ref :-  Book : Martindale    Page : 2646   Edition : 37  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Liver disease 1 Month 18 Month Oral 10 15 mg/kg b.d.
2 Cholestasis > 1 Day 18 Year Oral 10 mg/kg t.i.d.
3 Ulcerative colitis 1 Month 18 Year Oral 5 10 mg/kg b.d/t.i.d
4 Sclerosing cholangitis 1 Month 18 Year Oral 5 10 mg/kg b.d/t.i.d
5 Biliary atresia > 1 Day 2 Year Oral 5 mg/kg t.i.d.

Ref :- Book : Martindale    Page : 2646   Edition : 37  
►  Side Effect : Nausea, Vomiting, Diarrhea, Gastrointestinal disturbance, pruritus, Raised liver enzymes
Ref :-   Book : Martindale    Page : 2446   Edition : 37.  

►  Drug Interaction : Drug interaction of Ursodeoxycholic acid is with compound,  Propylthiouracil , Clofibrate, Verapamil , Sildenafil , Cholestyramine
Ref :-   Book : Martindale    Page : 2646   Edition : 37.  


  ►    Mechanism of Drug Drug Interaction :  Ursodeoxycholic acid should not be used with drugs that increase bile cholesterol such as oestrogenic hormones and cholesterol-lowering drugs such as clofibrate. Use with bile-acid binding drugs including antacids, charcoal, and colestyramine should be avoided since this may reduce the effectiveness of therapy with ursodeoxycholic acid
Ref :-   Book : Martindale    Page : 2646   Edition : 37.  


►  Contraindication : Intestinal disorder, Hepatic disorder
Ref :-   Book : Martindale    Page : 2646   Edition : 37.  
  ►  Mechanism of Action :   Ursodeoxycholic acid is a naturally occurring bile acid present in small quantities in human bile. Ursodeoxycholic, acid suppresses the synthesis and secretion of cholesterol by the liver and inhibits intestinal absorption of cholesterol.
Ref :-   Book : Martindale    Page : 2646   Edition : 37.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Garlic with Another pathway.  

  ►  Pathway with its reference as follows :-
  • Allin & Allicin is metabolized fat --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL --
  • http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Biliary, Fecal, Hepatic (Metabolism)
    Ref :-   Book : Martindale    Page : 2646   Edition : 37.  

    ►    Plasma Half-life :   Min value :-   100 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 2646   Edition : 37.  

    ►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : .