Valaciclovir is a Medicine belongs to Antiviral group whose information about Brand can be referenced from   Book : Martindale    Page : 1107   Edition : 37,

  ►   Brandname : Valcivir,Valtrex

  ►  Strength : Tablet with 500  mg, Tablet with 1000  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 889   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Basic & Clinical pharmacology    Page : 889   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Herpes zoster Oral 1 gm Tablet t.i.d. For 7 days.
2 Herpes simplex infections Oral 500 mg Tablet b.d. For 5 days.
3 CMV infection Oral 2 gm Tablet q.i.d.

Ref :-  Book : Martindale    Page : 1007   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Chickenpox 2 Year 18 Year Oral 20 mg/kg Tablet t.i.d.
2 CMV infection 12 Year Oral 2 gm Tablet q.i.d.
3 Herpes simplex infections 12 Year <12 Year Oral 500 mg Tablet b.d.
4 Herpes zoster infection 12 Year <12 Year Oral 1 gm Tablet t.i.d.

Ref :- Book : Martindale    Page : 1007   Edition : 37,
►  Side Effect : Increased serum bilirubin, Skin rashes, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, fever, headache, Dizziness, nausea, vomiting, diarrhea, lethargy, Somnolence, Confusion, hallucinations, agitation, tremor, Psychosis, convulsion, coma, thrombotic thrombocytopenic purpura, haemolytic uraemic syndrome, hepatitis, jaundice, Increased liver enzymes, haematological changes,
Ref :-   Book : Martindale    Page : 952   Edition : 37,

►  Drug Interaction : Drug interaction of Valaciclovir is with Probenecid ,
Ref :-   Book : Martindale    Page : 953   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Probenecid and other drugs that inhibit renal tubular secretion and resorption may reduce the renal clearance of ganciclovir, and so increase its serum concentrations. ,
Ref :-   Book : Martindale    Page : 953   Edition : 37,


►  Contraindication : renal impairment,
Ref :-   Book : Martindale    Page : 952   Edition : 37,
  ►  Mechanism of Action :   Valaciclovir is a prodrug of the antiviral aciclovir. Valaciclovir phosphorylated by viral kinases and then inhibit viral DNA polymerase. ,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 670   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Scarlet pimpernel i e Krishnaneel with Another pathway, Garlic with Another pathway, Garlic with Another pathway,

  ►  Pathway with its reference as follows :-
  • Triterpene saponins have Anti viral property --- (Kokate, C.K. and A.p. Purohit. Pharmacognosy. Nirali prakashan: Chennai, 2013. Print. )
  • Cucuritacins have Anti viral property --- ( Ruwali, P., Rai, N., Kumar, N., & Gautam, P. (2013). ANTIVIRAL POTENTIAL OF MEDICINAL PLANTS: AN OVERVIEW. INTERNATIONAL RESEARCH JOURNAL OF PHARMACY, 4(6), 8-16. )
  • Anti viral effect --- (Ruwali, P., Rai, N., Kumar, N., & Gautam, P. (2013). ANTIVIRAL POTENTIAL OF MEDICINAL PLANTS: AN OVERVIEW. INTERNATIONAL RESEARCH JOURNAL OF PHARMACY, 4(6), 8-16. )
  • Cucuritacins have Anti viral property --- ( Ruwali, P., Rai, N., Kumar, N., & Gautam, P. (2013). ANTIVIRAL POTENTIAL OF MEDICINAL PLANTS: AN OVERVIEW. INTERNATIONAL RESEARCH JOURNAL OF PHARMACY, 4(6), 8-16. )
  • Anti viral effect --- (Ruwali, P., Rai, N., Kumar, N., & Gautam, P. (2013). ANTIVIRAL POTENTIAL OF MEDICINAL PLANTS: AN OVERVIEW. INTERNATIONAL RESEARCH JOURNAL OF PHARMACY, 4(6), 8-16. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.htm, http://www.irjponline.com/admin/php/uploads/1825_pdf.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 1107   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   nf,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : ,

    ►    Peak Plasma Concentration :   Min value :-   1.5 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1107   Edition : 37,