Valganciclovir is a Medicine belongs to Antiviral group whose information about Brand can be referenced from   Book : Martindale    Page : 1007   Edition : 37  

  ►   Brandname : Valcyte
  ►  Strength : Capsule with 450 mg.  Oral solution with .  Tablet with

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 889   Edition : 12   Martindale    Page : 1022   Edition : 38  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Basic & Clinical pharmacology    Page : 889   Edition : 12  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Induction in patients with active CMV retinitis Oral 900 mg Capsule b.d. Dose: given daily for 21 days. For maintenance following induction, or in patients with inactive CMV retinitis, the dose is 900 mg daily.
2 Prevention of CMV disease in organ transplant recipients Oral 900 mg Capsule The dose is 900 mg daily starting within 10 days and continuing until 100 days after transplantation.

Ref :-  Book : Martindale    Page : 1008   Edition : 37  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 CMV disease 4 Month 16 Year Oral 450 mg Tablet

Ref :- Book : Martindale    Page : 1022   Edition : 38  
►  Side Effect : Neutropenia, Thrombocytopenia, Anaemia, Dyspnoea, Headache, Fever, Rashes, pruritus, Asthenia, CNS disturbances, Gastrointestinal disturbance, Abnormal liver fuction tests, Anaphylaxis, Arrhythmia, Hypotension, Pancreatitis, Haematuria, Metabolic, musculoskeletal, urogenital, and cutaneous symptoms
Ref :-   Book : Martindale    Page : 970   Edition : 37.  

►  Drug Interaction : Drug interaction of Valganciclovir is with Antineoplastic , , , ,  Zidovudine, Probenecid , Mycophenolate mofetil , Amphotericin B , Dapsone , Flucytosine , Hydroxycarbamide (Hydroxyurea), Pentamidine , Imipenem
Ref :-   Book : Martindale    Page : 971, 1007   Edition : 37.  


  ►    Mechanism of Drug Drug Interaction :  Zidovudine given with valganciclovir may have an additive neutropenic effect and should not normally be given during intravenous valganciclovir induction therapy, although it has been given with caution during oral maintenance therapy. Probenecid and other drugs that inhibit renal tubular secretion and resorption may reduce the renal clearance of valganciclovir, and so increase its serum concentrations. Use of intravenous ganciclovir with oral mycophenolate mofetil may result in increased plasma concentrations of both drugs due to competition for renal tubular secretion. Drugs that inhibit rapid cell division such as amphotericin B, some antineoplastic drugs, co-trimoxazole, dapsone, flucytosine, hydroxycarbamide, nucleoside analogues, and pentamidine may have additive toxic effects if given with valganciclovir. Convulsions have been reported when valganciclovir was given with imipenem and cilastatin.
Ref :-   Book : Martindale    Page : 971, 1007   Edition : 37.  


►  Contraindication : Renal impairment, Low blood counts, Cytopenic reactions, Pregnancy, Valganciclovir is not indicated for use in liver transplant recipients, because of reports of a higher incidence of tissue-invasive CMV infection
Ref :-   Book : Martindale    Page : 971, 1007   Edition : 37.  
  ►  Mechanism of Action :   Valganciclovir is a prodrug of the antiviral ganciclovir. Valganciclovir is phosphorylated by viral kinases and then inhibit viral DNA polymerase. Ref Martindale, pg no. 1008, ed. 37
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 670   Edition : 3.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


DIETARY Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication DIETARY Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Hepatic (Metabolism), Renal
Ref :-   Book : Martindale    Page : 1007,1008   Edition : 37.  

►    Plasma Half-life :   Min value :-   2 hours,    Max value :-   4 hours.  
Ref :-   Book : Goodman    Page : 1604   Edition : 12.  

►    Peak Plasma Concentration :   Min value :-   1 hour,    Max value :-   3 hours.  
Ref :-   Book : Martindale    Page : 1007   Edition : 37.