Valganciclovir is a Medicine belongs to Antiviral group whose information about Brand can be referenced from   Book : Martindale    Page : 1007   Edition : 37,

  ►   Brandname : Valcyte

  ►  Strength : Capsule with 450  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 889   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Basic & Clinical pharmacology    Page : 889   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 CMV retinitis Oral 900 mg Capsule b.d. For 21 days.
2 CMV disease Oral 900 mg Capsule In organ transplant recipients, daily starting within 10 days and continuing until 100 days after transplantation.

Ref :-  Book : Martindale    Page : 1008   Edition : 37, Martindale    Page : 1108   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 CMV disease 4 Month 16 Year Oral 450 mg Tablet

Ref :- Book : Martindale    Page : 1022   Edition : 38,
►  Side Effect : neutropenia, thrombocytopenia, anaemia, dyspnoea, headache, fever, Rashes, pruritus, asthenia, CNS disturbances, gastrointestinal disturbance, abnormal liver fuction tests, anaphylaxis, arrhythmia, hypotension, Pancreatitis,
Ref :-   Book : Martindale    Page : 970   Edition : 37,

►  Drug Interaction : Drug interaction of Valganciclovir is with Zidovudine, Probenecid , Amphotericin B , Nebivolol, cotrimoxazole, Dapsone , Flucytosine , Hydroxycarbamide (Hydroxyurea), Pegvisomant , Pentamidine ,
Ref :-   Book : Martindale    Page : 970   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Probenecid and other drugs that inhibit renal tubular secretion and resorption may reduce the renal clearance ofValganciclovir , and so increase its serum concentrations. Use of intravenous ganciclovir with oral mycophenolate mofetil may result in increased plasma concentrations of both drugs due to competition for renal tubular secretion. Convulsions have been reported when ganciclovir was given with imipenem and cilastatin.,
Ref :-   Book : Martindale    Page : 971   Edition : 37,


►  Contraindication : renal impairment, low blood counts, cytopenic reactions, pregnancy,
Ref :-   Book : Martindale    Page : 970   Edition : 37,
  ►  Mechanism of Action :   Valganciclovir is a prodrug of the antiviral ganciclovir. Valganciclovir is phosphorylated by viral kinases and then inhibit viral DNA polymerase.,
Ref :-   Book : Martindale    Page : 1007   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   NA


►    Plasma Half-life :
  Min value :-   2 hours,    Max value :-   4 hours,
Ref :-   Book : Goodman    Page : 1604   Edition : 12,

►    Peak Plasma Concentration :   Min value :-   1 hour,    Max value :-   3 hours,
Ref :-   Book : Martindale    Page : 1007   Edition : 37,