Valproic acid(sodium valproate) is a Medicine belongs to Antiseizure/Antipsychotic group whose information about Brand can be referenced from   Book : Martindale    Page : 558   Edition : 37,

  ►   Brandname : Depakene,Depacon,Depakote,Valparin

  ►  Strength : Capsule with 250  mg, Syrup with 250  mg/ml, Tablet with 125  mg, Tablet with 250  mg, Tablet with 500  mg, Injection with 100  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 427   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV, rectal,
Reference :-   Book : Martindale    Page : 557   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Epilepsy IV 10 mg/kg Injection Over 3 to 5 minutes.
2 Epilepsy Oral 10 15 mg/kg Daily.
3 Migraine Oral 250 mg b.d. Daily.
4 Epilepsy Oral 600 mg In 2 divided doses.
5 Bipolar disorder Oral 750 mg Daily in 2 to 3 divided doses.

Ref :-  Book : Martindale    Page : 557   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Infantile spasms < 20 kg Oral 400 mg
2 Infantile spasms > 20 kg Oral 20 mg/kg
3 Infantile spasms > 1 Day >28 Day Oral 20 mg/kg o.d.
4 Infantile spasms 1 Month 12 Year Oral 5 7.5 mg/kg b.d.
5 Infantile spasms IV 20 30 mg/kg Injection
6 Epilepsy 18 Year IV 10 mg/kg Injection b.d.
7 Epilepsy 1 Month 12 Year IV 10 mg/kg Injection
8 Epilepsy 10 Year < 10 Year Oral 600 mg
9 Seizures < 20 kg Oral 400 mg
10 Seizures > 1 Day > 28 Day Oral 20 mg/kg o.d.
11 Seizures 1 Month 12 Year Oral 5 7.5 mg/kg b.d.
12 Seizures IV 20 30 mg/kg Injection

Ref :- Book : Martindale    Page : 557   Edition : 37,
Precaution :- If a Patient is using 'Valproic acid(sodium valproate)' drug in  Acute Intermittent Porphyria  disease, then Please Do not use .

Precaution :- If a Patient is using 'Valproic acid(sodium valproate)' drug in ACUTE VIRAL HEPATITIS disease, then Please should be avoided   if he ever suffered from Epilapsy disease.
►  Side Effect : oedema, headache, prolongation of bleeding time, bone-marrow depression, leukopenia, thrombocytopenia, ataxia, Confusion, lethargy, Sedation, tremor, behavioural disturbances, Hearing loss, hyperactivity, encephalopathy, extrapyramidal disorders, acne, amenorrhoea, cerebral atrophy, dementia, Gynaecomastia, hair loss, hepatic failure, Hirsutism, Hyperglycaemia, Irregular period, rash, regrowth of curly hair, Stevens-Johnson syndrome, toxic epidermal necrolysis, coma, fatalities, Pancreatitis, erythema multiforme,
Ref :-   Book : Martindale    Page : 553   Edition : 37,

►  Drug Interaction : Drug interaction of Valproic acid(sodium valproate) is with Phenytoin , Phenobarbital , Lamotrigine , Lorazepam , Clonazepam, Aspirin, Warfarin ,
Ref :-   Book : Martindale    Page : 555   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  There are complex interactions between antiepileptics and toxicity may be enhanced without a corresponding increase in antiepileptic activity. Such interactions are very variable and unpredictable and plasma monitoring is often advisable with combination therapy. Caution is recommended when giving valproate with other drugs liable to interfere with blood coagulation, such as aspirin or warfarin. Use with other hepatotoxic drugs should be avoided. Use of highly protein bound drugs with valproate may increase free valproate plasma concentrations,
Ref :-   Book : Martindale    Page : 555   Edition : 37,


►  Contraindication : hepatic disease, hepatic dysfunction, Congenital metabolic or degenerative disorders, organic brain disease, Severe seizure disorder, pregnancy, Mental illness,
Ref :-   Book : Martindale    Page : 555   Edition : 37,
  ►  Mechanism of Action :   Valporic acid stimulate the activity of the GABA synthetic enzyme and inhibit GABA degradative enzyme, it block sustained high frequency repetitive firing of neurons. It alters Na, K and Ca conductance, membrane potential and the concentration of amino acids and the Neurotransmitters NE, ACH and GABA,
Ref :-   Book : Goodman    Page : 597   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Baccopa monnerie with Another pathway, Valerian with Another pathway,

  ►  Pathway with its reference as follows :-
  • d -amphetamine in brahmi have anti epilepsy property --- (K, M. (2016). Medicinal Plant in the Treatment of Epilepsy. Internaional Research Journal Of Pharmacy, 2(2). )
  • Anticonvulsant --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://www.irjponline.com/admin/php/uploads/vol2-issue2/6.pdf, http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- VITAMIN B12 with Decrease in Nutrient Level, VITAMIN B12 with Decrease in Nutrient Level, VITAMIN B12 with Long -term anticonvulsant treatment decrease blood levels of biotin ., CALCIUM with Long-term develop below normal blood levels of calcium , which may be related to drug -induced vitamin -D deficiency. ., FOLIC ACID with Reduces blood levels of folic acid dramatically increases homocysteine levels ., GINKGO BILOBA with Dietary Substance is Drug Inhibitor, BIOTIN with Decrease in Nutrient Level, COPPER with Decrease in Nutrient Level, VITAMIN A with Decrease in Nutrient Level, VITAMIN A with Decrease in Nutrient Level, VITAMIN D with Decrease in Nutrient Level, VITAMIN K with Decrease in Nutrient Level, VITAMIN E with Decrease in Nutrient Level, ZINC with Decrease in Nutrient Level, CALCIUM with Decrease in Nutrient Level, CARNITINE with Decrease in Nutrient Level,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Williamson, E. (2009). Stockley's Herbal Medicines Interaction .. London: Pharmacutical press.
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf, http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf, https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- with Cause anxiety, confusion and other side effect , IODINE with Incerase side effect , GINKGO BILOBA with cause seisures in patient taking valporate .,

      ►  Reference :-
  • Williamson, E. (2009). Stockley's Herbal Medicines Interaction .. London: Pharmacutical press.
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Williamson, E. (2009). Stockley's Herbal Medicines Interaction .. London: Pharmacutical press.

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20, https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf,

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 556   Edition : 37,


    ►    Plasma Half-life :   Min value :-   5 hours,    Max value :-   20 hours,
    Ref :-   Book : Martindale    Page : 556   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   1 hour,    Max value :-   4 hour,
    Ref :-   Book : Goodman    Page : 597   Edition : 12th,