Vancomycin is a Medicine belongs to GLYCOPEPTIDE ANTIBIOTICS group whose information about Brand can be referenced from   Book : Martindale    Page : 387   Edition : 38,

  ►   Brandname : Covancin,Vancogram,Vancocin,Vancoled

  ►  Strength : Injection with 0.5  gm, Injection with 1  gm, Injection with 5  gm, Injection with 10  gm, Solution with 250/5  mg/ml, Solution with 500/6  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 808   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV, intrathecal , Oral, Topical, inhalation,
Reference :-   Book : Martindale    Page : 384   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 MRSA infection IV 500 mg Injection q.i.d.
2 Dosing in Obesity: In critically in patient give 25-30 mg/kg of actual BW IV load, then 15-20 mg/kg of actual BW IV q8h-12h (Infuse over 1.5-2 hr). No single dose over 2 gm Ref; The Sanford Guide To Antimicrobial Therapy, pg 232, ed 47

Ref :-  Book : Martindale    Page : 384   Edition : 38,    Page :    Edition : ,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Mild to moderate infections > 1 Day 1 Month IV 15 mg/kg Injection

Ref :- Book : Martindale    Page : 384   Edition : 38,
►  Organ Affected Ototoxicity (Vestibular & cochlear disorders)  

Precaution :- If a Patient is using 'Vancomycin' drug in  acute kidney injury   disease, then Please be avoided .

Precaution :- If a Patient is using 'Vancomycin' drug in  Acute Kidney Injury  disease, then Please to be used in renal modified doses .

Precaution :- If a Patient is using 'Vancomycin' drug in  Acute Renal Failure  disease, then Please also avoid or give renal adjusted doses of cephalosporins,and other penicillins and aminoglycosides .

Precaution :- If a Patient is using 'Vancomycin' drug in  Endocarditis-associated glomerulonephritis   disease, then Please Contraindication- Hypersensitivity reaction. .

Precaution :- If a Patient is using 'Vancomycin' drug in  Endocarditis-associated glomerulonephritis   disease, then Please Cautions- Pruritis Hypotension Erythema urticaria .

Precaution :- If a Patient is using 'Vancomycin' drug in  Endocarditis-associated glomerulonephritis   disease, then Please Caution- Ototoxicity .

Precaution :- If a Patient is using 'Vancomycin' drug in  Endocarditis-associated glomerulonephritis   disease, then Please Caution- Risk of neutropenia increases with doses >25 g (reversible following discontinuation of therapy) .

Precaution :- If a Patient is using 'Vancomycin' drug in  Endocarditis-associated glomerulonephritis   disease, then Please Caution- Prolonged use may result in fungal or bacterial superinfection Use caution in patients with renal impairment; monitor trough concentrations if multiple oral doses administered .

Precaution :- If a Patient is using 'Vancomycin' drug in  Endocarditis-associated glomerulonephritis   disease, then Please Lactation: Drug enters breast milk; not recommended .

►  Side Effect : irritating to tissue, phlebitis, chills, fever, nephrotoxic, ototoxic, erythematous rash, flushing, hypotension, tachycardia, red man” or “red neck” syndrome,
Ref :-   Book : Basic & Clinical pharmacology    Page : 803   Edition : 12,

►  Drug Interaction : Drug interaction of Vancomycin is with Paracetamol , , Cyclosporine , Cisplatin , Tenecteplase , Testosterone , Suxamethonium/Succinylcholinechloride (Suxamethonium chloride) ,
Ref :-   Book : Martindale    Page : 386   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Other ototoxic or nephrotoxic drugs, such as aminoglycosides, polymyxins, cisplatin, and loop diuretics, are likely to increase the risk of toxicity and if they need to be given with vancomycin caution and appropriate monitoring are recommended. Some of the adverse effects of vancomycin may be enhanced by the use of general anaesthetics; it has been suggested that, where patients require both, vancomycin infusions should be completed before the induction of anaesthesia. Vancomycin may increase neuromuscular blockade produced by drugs such as suxamethonium or vecuronium.,
Ref :-   Book : Martindale    Page : 386   Edition : 38,


►  Absolute Contraindication : Hypersensitivity reaction   patients with a history of impaired hearing.  

►  Contraindication : Hypersensitivity, Impaired hearing,
Ref :-   Book : Martindale    Page : 386   Edition : 38,
  ►  Mechanism of Action :   Vancomycin inhibits cell wall synthesis by binding firmly to the D-Ala-D-Ala terminus of nascent peptidoglycan pentapeptide. This inhibits the transglycosylase, preventing further elongation of peptidoglycan and cross-linking. The peptidoglycan is thus weakened, and the cell becomes susceptible to lysis. The cell membrane is also damaged, which contributes to the antibacterial effect. ,
Ref :-   Book : Basic & Clinical pharmacology    Page : 802   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Red algae with Another pathway, penicillin with Another pathway,

  ►  Pathway with its reference as follows :-
  • Triterpenes have Antibiotic effect --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )
  • Indole have Antibiotic effect --- (Nabavi, S. (2015). Antibacterial Effects of Cinnamon: From Farm to Food, Cosmetic and Pharmaceutical Industries Seyed Fazel. Nutrients, 7(2072-6643), 7729-7748;. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html, www.mdpi.com/2072-6643/7/9/5359/pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- IRON with Dietary Substance is Drug Inhibitor,

      ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 390   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   3 hours,    Max value :-   13 hours,
    Ref :-   Book : Martindale    Page : 390   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   1 hour,    Max value :-   2 hours,
    Ref :-   Book : Basic & Clinical pharmacology    Page : 802   Edition : 12,