Venlafaxine is a Medicine belongs to Antidepressant group whose information about Brand can be referenced from   Book : Martindale    Page : 462   Edition : 37  

  ►   Brandname : Flavix, Venlor, Effexor, Depefex
  ►  Strength : Tablet with 25 mg.  Tablet with 37.5 mg.  Tablet with 50 mg.  Tablet with 75 mg.  Tablet with 100 mg.  Capsule with 37.5 mg.  Capsule with 75 mg.  Capsule with 150 mg. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 539   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 461   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Depression Oral 75 mg Daily two or three divided doses with food.
2 Generalised anxiety disorder Oral 75 mg o.d. Daily.
3 Social anxiety disorder Oral 75 mg o.d.
4 Panic disorder Oral 37.5 mg o.d.

Ref :-  Book : Martindale    Page : 461   Edition : 37  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Depression Oral 75 375 mg
2 Anxiety Oral 75 375 mg

Ref :- Book : Nelson's textbook of Pediatrics    Page : 63   Edition : 19  
►  Side Effect : NA

►  Drug Interaction : Drug interaction of Venlafaxine is with Acarbose , Abatacept , Chlorpromazine
Ref :-   Book : Martindale    Page : 461   Edition : 37.  


  ►    Mechanism of Drug Drug Interaction :  Conversion of venlafaxine to its equally active metabolite Odesmethylvenlafaxine is mediated by the cytochrome P450 isoenzyme CYP2D6. Venlafaxine is also metabolised by CYP3A4 to the less active metabolite N-desmethylvenlafaxine. This is a relatively minor pathway and the potential for clinically significant interactions between venlafaxine and CYP3A4 inhibitors is considered to be small. However, potent inhibitors of CYP3A4 or drugs that inhibit both CYP2D6 and CYP3A4 could significantly increase venlafaxine concentrations in patients who are poor CYP2D6 metabolisers; such combinations should therefore be used with caution. Venlafaxine itself is considered to be a relatively weak inhibitor of CYP2D6. Venlafaxine should not be used with MAOIs and at least 14 days should elapse between stopping an MAOI and starting treatment with venlafaxine
Ref :-   Book : Martindale    Page : 461   Edition : 37.  


►  Contraindication : Ventricular arrhythmia, , Epilepsy, Myocardial infraction
Ref :-   Book : Martindale    Page : 460   Edition : 37.  
  ►  Mechanism of Action :   Venlafaxine, a phenylethylamine derivative, is a serotonin and noradrenaline reuptake inhibitor (SNRI); it also weakly inhibits dopamine reuptake. It is reported to have little affinity for muscarinic, histaminergic, or α1-adrenergic receptors in vitro.
Ref :-   Book : Martindale    Page : 461   Edition : 37.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA NA


DIETARY Substance Interactions


​   ► This Medicine interact with :- SODIUM with Decrease in Nutrient Level.  

  ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf


    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- 5 HTP(5-HYDROXYTRYPTOPHAN) with Increase the side effects of drug ..   L- TRYPTOPHAN with It increases the side effect of drug ..   SODIUM with Drug with sodium causes hyponatremia..   SOUR DATE NUT(ZIZIPHUS JUJUBE) with Sour date nut interact with drug.   ST. JOHNS WORT(HYPERICUM PERFORATUM) with St john wort interact with venlafaxine ..  

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf

    ►   Route of Elimination :   Fecal, Hepatic (Metabolism), Renal
    Ref :-   Book : Martindale    Page : 461   Edition : 37.  

    ►    Plasma Half-life :   Min value :-   5 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 461   Edition : 37.  

    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 461   Edition : 37.