Venlafaxine is a Medicine belongs to Antidepressant group whose information about Brand can be referenced from   Book : Martindale    Page : 462   Edition : 37  

  ►   Brandname : Flavix, Venlor, Effexor, Depefex, Trevilor, Efexor
  ►  Strength : Tablet with 25 mg.  Tablet with 37.5 mg.  Tablet with 50 mg.  Tablet with 75 mg.  Tablet with 100 mg.  Extended- release capsule with 37.5 mg.  Extended- release capsule with 75 mg.  Extended- release capsule with 150 mg. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 539   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 461   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Depression Oral 75 mg Given in two or three divided doses.
2 Generalised anxiety disorder Oral 75 mg o.d.
3 Social anxiety disorder Oral 75 mg o.d.
4 Panic disorder Oral 37.5 mg o.d. Given with or without agoraphobia in doses of 37.5 mg once daily for the first 7 days, then increasing to 75 mg daily. Subsequent increases in increments of up to 75 mg may be made at intervals of at least 7 days, to a maximum dose of 225 mg daily. Subsequent increases in increments of up to 75 mg may be made to a maximum dose of 225 mg daily. The interval between dose increases is usually 2 weeks or more, and should be at least 7 days.

Ref :-  Book : Martindale    Page : 461   Edition : 37  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Depression Oral 75 375 mg
2 Anxiety Oral 75 375 mg

Ref :- Book : Nelson's textbook of Pediatrics    Page : 63   Edition : 19  
►  Side Effect : Mucous membrane bleeding, Nausea, Headache, Insomnia, Somnolence, Dry mouth, Dizziness, Constipation, Sexual dysfunction, Asthenia, Sweating, Nervousness, Anorexia, Diarrhoea, Dyspepsia, Abdominal pain, Anxiety, Urinary frequency, Visual disturbances, Mydriasis, Vasodilatation, Vomiting, Tremor, Paraesthesia, Hypertonia, Chills, Fever, palpitations, Weight gain, Weight loss, Increased serum-cholesterol, Agitation, Abnormal dreams, Confusion, Arthralgia, Myalgia, Tinnitus, pruritus, Dyspnoea, Yawning, Rashes, Reversible increases in liver enzymes, Orthostatic hypotension, Syncope, Arrhythmias, Tachycardia, Ecchymoses, Hallucinations, Bruxism, Muscle spasm, Myoclonus, Alopecia, Altered taste, Urinary retention, Menorrhagia, Angioedema, Photosensitivity reactions
Ref :-   Book : Martindale    Page : 459   Edition : 37.  

►  Drug Interaction : Drug interaction of Venlafaxine is with Monoamine Oxidase Inhibitors,  NA

  ►    Mechanism of Drug Drug Interaction :  Conversion of venlafaxine to its equally active metabolite Odesmethylvenlafaxine is mediated by the cytochrome P450 isoenzyme CYP2D6. Venlafaxine is also metabolised by CYP3A4 to the less active metabolite N-desmethylvenlafaxine. This is a relatively minor pathway and the potential for clinically significant interactions between venlafaxine and CYP3A4 inhibitors is considered to be small. However, potent inhibitors of CYP3A4 or drugs that inhibit both CYP2D6 and CYP3A4 could significantly increase venlafaxine concentrations in patients who are poor CYP2D6 metabolisers; such combinations should therefore be used with caution. Venlafaxine itself is considered to be a relatively weak inhibitor of CYP2D6. Venlafaxine should not be used with MAOIs and at least 14 days should elapse between stopping an MAOI and starting treatment with venlafaxine
Ref :-   Book : Martindale    Page : 461   Edition : 37.  


►  Contraindication : Venlafaxine should not be used in patients with an identified very high risk of a serious ventricular arrhythmia or uncontrolled hypertension. Caution is advised in those with a recent history of myocardial infarction or whose condition might be exacerbated by an increase in heart rate., Venlafaxine should be used with caution in patients with moderate to severe hepatic or renal impairment and dosage adjustment may be necessary. It should also be used with caution in patients with a history of epilepsy and avoided in those with unstable disease; it should be stopped in any patient developing a seizure or if there is an increase in seizure frequency., As with other antidepressants, venlafaxine may impair performance of skilled tasks and, if affected, patients should not drive or operate machinery. Patients, especially the elderly, should be warned of the risk of dizziness or unsteadiness due to orthostatic hypotension.
Ref :-   Book : Martindale    Page : 460   Edition : 37.  
  ►  Mechanism of Action :   Venlafaxine, a phenylethylamine derivative, is a serotonin and noradrenaline reuptake inhibitor (SNRI); it also weakly inhibits dopamine reuptake. It is reported to have little affinity for muscarinic, histaminergic, or α1-adrenergic receptors in vitro.
Ref :-   Book : Martindale    Page : 461   Edition : 37.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA NA NA


DIETARY Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication DIETARY Substance


​   ► This Medicine contraindicate with :- NA L- TRYPTOPHAN with It increases the side effect of drug ..   SODIUM with Drug with sodium causes hyponatremia..   SOUR DATE NUT(ZIZIPHUS JUJUBE) with Sour date nut interact with drug.   ST. JOHNS WORT(HYPERICUM PERFORATUM) with St john wort interact with venlafaxine ..  

  ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf

    ►   Route of Elimination :   Hepatic (Metabolism), Renal, Faecal
    Ref :-   Book : Martindale    Page : 461   Edition : 37.  

    ►    Plasma Half-life :   Min value :-   5 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 461   Edition : 37.  

    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 461   Edition : 37.