Vigabatrin is a Medicine belongs to Antiseizure drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 560   Edition : 37,

  ►   Brandname : Sabril

  ►  Strength : Tablet with 500  mg, Powder with 500  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 427   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 560   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Adjunctive therapy Oral 1 gm Tablet Daily.

Ref :-  Book : Martindale    Page : 560   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Adjunctive therapy Oral 40 mg/kg Tablet
2 Infantile spasms Oral 50 mg/kg Tablet
3 Infantile spasms Oral 15 25 mg/kg Tablet b.d.

Ref :- Book : Martindale    Page : 558   Edition : 38,
Precaution :- If a Patient is using 'Vigabatrin' drug in  iron poisoning  disease, then Please decreases the chelation effect of desferoxamine .

►  Side Effect : drowsiness, fatigue, Dizziness, headache, ataxia, paraesthesia, tremor, impaired concentration, Confusion, weight gain, gastrointestinal disturbance, oedema, alopecia, angioedema, Urticaria, Skin rashes, Visual field defect, diplopia, nystagmus, agitation, aggression, irritability, Nervousness, Depression, Sedation, stupor, encephalopathy, Psychosis, hypomania, mania, atrophy, Memory disturbance,
Ref :-   Book : Martindale    Page : 558-559   Edition : 37,

►  Drug Interaction : Drug interaction of Vigabatrin is with Carbamazapine , Phenobarbital , Phenytoin ,
Ref :-   Book : Martindale    Page : 559   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  There are complex interactions between antiepileptics and toxicity may be enhanced without a corresponding increase in antiepileptic activity. Such interactions are very variable and unpredictable and plasma monitoring is often advisable with combination therapy. ,
Ref :-   Book : Martindale    Page : 559   Edition : 37,


►  Contraindication : renal impairment,
Ref :-   Book : Martindale    Page : 559   Edition : 37,
  ►  Mechanism of Action :   Irreversibly inhibit GABA- transaminase.,
Ref :-   Book : Basic & Clinical pharmacology    Page : 426   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Duchhman"s breeches with same pathway, Chamomile with , Green tea with same pathway,

  ►  Pathway with its reference as follows :-
  • Herb dutchman"s breeches having active compound bicuculline which act as GABA receptore antagonist . --- ( Johnston, G., & Chebib, M. (2009). Herbal Products and GABA Receptors. Encyclopedia Of Neuroscience, 4, 1095-1101. )
  • Chamomile is a herb having active compound apigenin which bind GABA receptors . --- (Sreenath, K., & Venkatesh, Y. (2010). Quantification of Xylitol in Foods by an Indirect Competitive Immunoassay. Journal Of Agricultural And Food Chemistry, 58(2), 1240-1246. http://dx.doi.org/10.1021/jf903150c )
  • Green tea having active compound EGCG which bind GABA receptors . --- (Johnston, G., & Chebib, M. (2009). Herbal Products and GABA Receptors. Encyclopedia Of Neuroscience, 4, 1095-1101. )

  •   ►  URL -- https://pdfs.semanticscholar.org/29c9/cd318614fd90fc9dda0ece219069af3d7dfc.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 559   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   5 hours,    Max value :-   8 hours,
    Ref :-   Book : Martindale    Page : 559   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : ,