Vinblastine suphate is a Medicine belongs to Drugs used in disorder of coagulation group whose information about Brand can be referenced from   Book : Martindale    Page : 868   Edition : 37,

  ►   Brandname : Cytoblastin,Velban

  ►  Strength : Injection with 10  mg,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 868   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV,
Reference :-   Book : Martindale    Page : 868   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Hodgkin’s lymphomas IV 6 mg/m2 Injection Not more than once every 7 days.

Ref :-  Book : Martindale    Page : 881   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Chemotherapy IV 6 mg/m2 Injection o.d.

Ref :- Book : Martindale    Page : 881   Edition : 38,
►  Side Effect : leucopenia, GI disturbances, nausea, vomiting, anorexia, diarrhea, neurotoxicity, anaphylaxis, Anaphylactoid reactions,
Ref :-   Book : Martindale    Page : 868   Edition : 37,

►  Drug Interaction : Drug interaction of Vinblastine suphate is with Phenytoin ,
Ref :-   Book : Martindale    Page : 868   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  phenytoin inhibits cytochromes of the CYP3A subfamily may result in decreased metabolism of vinblastine and increased toxicity. Use with drugs that inhibit cytochromes of the CYP3A subfamily may result in decreased metabolism of vinblastine and increased toxicity,
Ref :-   Book : Martindale    Page : 868   Edition : 37,


►  Contraindication : skin ulceration, Thromboembolic phenomenon,
Ref :-   Book : Martindale    Page : 868   Edition : 37,
  ►  Mechanism of Action :   Vinblastine sulfate is an antineoplastic agent that apparently acts by binding to the microtubular proteins of the spindle and arresting mitosis at the metaphase; it is thus specific for the M phase of the cell cycle. It also interferes with glutamate metabolism and possibly nucleic acid synthesis, and has some immunosuppressant activity.,
Ref :-   Book : Martindale    Page : 868   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Vinca with same compound, Tomato with Another pathway,

  ►  Pathway with its reference as follows :-
  • Vincristine arrests multiplication of cancerous cells --- (Kokate, c. & Purohit, A. (2016). pharmacognosy. nirali prakashan. )
  • lycopene have anticancer effect --- ( Al-Asmari, A., Albalawi, S., Athar, M., Khan, A., Al-Shahrani, H., & Islam, M. (2015). Moringa oleifera as an Anti-Cancer Agent against Breast and Colorectal Cancer Cell Lines. PLOS ONE, 10(8), e0135814. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545797/,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Biliary, Fecal, Renal,
    Ref :-   Book : Martindale    Page : 868   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   23 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 868   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : ,