Vincristine is a Medicine belongs to Antineoplastic group whose information about Brand can be referenced from   Book : Martindale    Page : 870, 871   Edition : 37  

  ►   Brandname : Cellcristin; Farmistin; Biocristine; Cytocristin; Neocristin; Oncovin; Vincasar PFS;
  ►  Strength :

A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV
Reference :-   Book : Martindale    Page : 869   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Antineoplastic IV Injection Vincristine sulfate is given by intravenous injection. Care should be taken to avoid extravasation and the injection may be given over 1 minute into a freely-running intravenous infusion (usually sodium chloride 0.9%) if preferred. The usual dose of vincristine sulfate is 1.4 to 1.5 mg/m2 once weekly, up to a maximum weekly dose of 2 mg. Blood counts should be carried out before giving each dose.

Ref :-  Book : Martindale    Page : 870   Edition : 37  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Paediatric tumours over 10 kg IV 1.4 2 mg/m2 Injection

Ref :- Book : Martindale    Page : 870   Edition : 37  
►  Side Effect : Malaise, Weakness, Headache, Depression, Paraesthesia, Numbness, Loss of deep tendon reflexes, Peripheral neuropathies, Constipation, Adynamic ileus, Jaw pain, Convulsions, Dizziness, Nystagmus, Vertigo, Partial or total deafness, Skin reactions, Alopecia, Ischaemic cardiotoxicity, Hypertension, Dyspnoea, Bronchospasm, Bone and tumour pain, Irritant to the skin and mucous membrane and extravasation may cause necrosis, cellulitis, and sloughing, Bone marrow depression, Urinary disturbances
Ref :-   Book : Martindale    Page : 868,871   Edition : 37.  

►  Drug Interaction : Drug interaction of Vincristine is with , ,  NA

  ►    Mechanism of Drug Drug Interaction :  Use of vincristine with drugs that inhibit cytochromes of the CYP3A subfamily may result in decreased metabolism of vincristine and increased toxicity. If vincristine is used with asparaginase it should be given 12 to 24 hours before the enzyme: giving asparaginase with or before vincristine may reduce vincristine clearance and increase toxicity.
Ref :-   Book : Martindale    Page : 869   Edition : 37.  

►  Contraindication : Because severe constipation and impaction of faeces often occur with vincristine, laxatives or enemas may be necessary to ensure regular bowel function. Vincristine should be given with caution to patients with preexisting neuromuscular disease and is contra-indicated in patients with the demyelinating form of Charcot- Marie-Tooth syndrome, Doses may need to be adjusted in patients with hepatic impairment. Care should also be taken in elderly patients, who may be more susceptible to neurotoxicity., Intrathecal use of the vinca alkaloids is contra-indicated because of the likelihood of fatal neurotoxicity, It should not be injected into an extremity with impaired circulation because of an increased risk of thrombosis. It should be given with caution and at reduced dosage to patients with hepatic impairment
Ref :-   Book : Martindale    Page : 868,869   Edition : 37.  
  ►  Mechanism of Action :   Vincristine is an antineoplastic agent that apparently acts by binding to the microtubular proteins of the spindle and arresting mitosis at the metaphase; it is thus specific for the M phase of the cell cycle. It also interferes with glutamate metabolism and possibly nucleic acid synthesis, and has some immunosuppressant activity. Significant
Ref :-   Book : Martindale    Page : 868, 870   Edition : 37.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- Vinca with same compoundAnother pathway.   Vinca with same compoundAnother pathway.   Sahijan i.e. maringa olifera with Another pathway.  

  ►  Pathway with its reference as follows :-
  • Anticancer property --- ( Al-Asmari, A., Albalawi, S., Athar, M., Khan, A., Al-Shahrani, H., & Islam, M. (2015). Moringa oleifera as an Anti-Cancer Agent against Breast and Colorectal Cancer Cell Lines. PLOS ONE, 10(8), e0135814 )
  • It arrests multiplication of cancerous cells by breaking down the microtubules into smaller subunits, thus inhibiting the cell division. --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )
  • It arrests multiplication of cancerous cells --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

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  • DIETARY Substance Interactions

    ​   ► This Medicine interact with :- NA

    ContraIndication DIETARY Substance

    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal
    Ref :-   Book : Martindale    Page : 869   Edition : 37.  

    ►    Plasma Half-life :   Min value :-   NA    Max value :-   NA

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA