Vincristine is a Medicine belongs to Drugs used in disorder of coagulation group whose information about Brand can be referenced from   Book : Martindale    Page : 869   Edition : 37,

  ►   Brandname : Alcrist,Vinlon,Biocristin,Cytocristin,Neocristin

  ►  Strength : Injection with 1  mg/ml, Injection with 5  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 869   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV,
Reference :-   Book : Martindale    Page : 869   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Hodgkin’s disease IV infusion 1.4 1.5 mg/m2 Injection QWK
2 Acute and chronic leukemia IV infusion 1.4 1.5 mg/m2 Injection QWK

Ref :-  Book : Martindale    Page : 870   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Tumour < 10 kg IV 1.4 2 mg/m2 Injection QWK

Ref :- Book : Martindale    Page : 870   Edition : 37,
►  Side Effect : progressive neurological toxicity, severe constipation, abdominal pain, obstruction, anaphylaxis, Anaphylactoid reactions,
Ref :-   Book : Martindale    Page : 869   Edition : 37,

►  Drug Interaction : Drug interaction of Vincristine is with Ethanol , asparaginase,
Ref :-   Book : Martindale    Page : 869   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Use of vincristine with drugs that inhibit cytochromes of the CYP3A subfamily may result in decreased metabolism of vincristine and increased toxicity. If vincristine is used with asparaginase it should be given 12 to 24 hours before the enzyme: giving asparaginase with or before vincristine may reduce vincristine clearance and increase toxicity.,
Ref :-   Book : Martindale    Page : 869   Edition : 37,


►  Contraindication : ,
Ref :-   Book :    Page :    Edition : ,
  ►  Mechanism of Action :   It involves inhibition of tubulin polymerization which results in mitotic arrest in metaphase, bringing cells division to a halt which leads to cells death ,
Ref :-   Book : Martindale    Page : 869   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Vinca with same compoundAnother pathway, Vinca with same compoundAnother pathway, Sahijan i.e. maringa olifera with Another pathway,

  ►  Pathway with its reference as follows :-
  • It arrests multiplication of cancerous cells by breaking down the microtubules into smaller subunits, thus inhibiting the cell division. --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )
  • It arrests multiplication of cancerous cells --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )
  • It arrests multiplication of cancerous cells by breaking down the microtubules into smaller subunits, thus inhibiting the cell division. --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )
  • It arrests multiplication of cancerous cells --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )
  • Anticancer property --- ( Al-Asmari, A., Albalawi, S., Athar, M., Khan, A., Al-Shahrani, H., & Islam, M. (2015). Moringa oleifera as an Anti-Cancer Agent against Breast and Colorectal Cancer Cell Lines. PLOS ONE, 10(8), e0135814 )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545797/,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 869   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA