Vitamin A (Retinol) is a Medicine belongs to Vitamin group whose information about Brand can be referenced from   Book : Martindale    Page : 2136   Edition : 37,    Page :   Edition : ,

  ►   Brandname : Biovit-A,Aquasol A,Palmitate-A,Pedi-Vit-A,Retinol-A,A to Z,Zincovit

  ►  Strength : Capsule with nf  ,

Reference of this Medicine for its Strength can be taken from   Book :    Page :    Edition : ,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV,
Reference :-   Book : Martindale    Page : 2099   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Vitamin A deficiency IM 100000 units Injection Every 2 to 4 months.

Ref :-  Book : Martindale    Page : 2134   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Cholestatic liver disease > 1 Day <1 Year IM 50000 units Injection
2 Xerophthalmia Oral 1500 µg/kg

Ref :- Book : Martindale    Page : 2099   Edition : 38, Nelson's textbook of Pediatrics    Page : 190   Edition : 19,
►  Side Effect : fatigue, irritability, anorexia, vomiting, gastrointestinal disturbance, weight loss, low-grade fever, hepatomegaly, skin changes, pruritus, alopecia, dry hair, cracking, bleeding lips, anaemia, headache, hypercalcaemia, subcutaneous swelling, nocturia, raised intracranial pressure, papilloedema, mimicking brain tumors, visual disturbances, arrested bone growth, Sedation, Dizziness, Confusion, diarrhea, sore mouth, bleeding gums, desquamation, increased intracranial pressure, bulging fontanelle in infants, severe headache in adults, pains in bones and joints,
Ref :-   Book : Martindale    Page : 2101   Edition : 38,

►  Drug Interaction : Drug interaction of Vitamin A (Retinol) is with Neomycin , Cholestyramine , Liquid paraffin , Isotretinoin, Tretinoin,
Ref :-   Book : Martindale    Page : 2102   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Absorption of vitamin A from the gastrointestinal tract may be reduced by the presence of neomycin, colestyramine, liquid paraffin. There is an increased risk of hypervitaminosis A if vitamin A is given with synthetic retinoids such as acitretin, isotretinoin, and tretinoin. ,
Ref :-   Book : Martindale    Page : 2102   Edition : 38,


►  Contraindication : hepatic disease, pregnancy, cholestatic jaundice, fat-malabsorption,
Ref :-   Book : Martindale    Page : 2101   Edition : 38,
  ►  Mechanism of Action :   In isolated fibroblasts or epithelial tissue, retinoids enhance the synthesis of some proteins (e.g., fibronectin) and reduce the synthesis of others (e.g. collagenase, certain species of keratin), and molecular evidence suggests that these actions can be entirely accounted for by changes in nuclear transcription. ,
Ref :-   Book : Goodman    Page : 1797,1798   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- with same compoundsame compound, with same compoundsame compound, Carrot with same compound,

  ►  Pathway with its reference as follows :-
  • Nutritional Supplement --- (Gopalan, C. (2012). Nutritive value of Indian foods. National Institute of Nutrition ,ICMR.: Hyderabad 500007,INDIA. )
  • Nutritional supplement --- (Swaminathan, M. (2016). Advanced Text-Book On Food & Nutrition vol 2. Bangalore: Wesley press,Mysore and Diocesan press Madras. )
  • Nutritional Supplement --- (Gopalan, C. (2012). Nutritive value of Indian foods. National Institute of Nutrition ,ICMR.: Hyderabad 500007,INDIA. )
  • Nutritional supplement --- (Swaminathan, M. (2016). Advanced Text-Book On Food & Nutrition vol 2. Bangalore: Wesley press,Mysore and Diocesan press Madras. )
  • Nutritional supplement --- (Swaminathan, M. (2016). Advanced Text-Book On Food & Nutrition vol 2. Bangalore: Wesley press,Mysore and Diocesan press Madras. )

  •   ►  URL -- https://books.google.co.in/books/about/Nutritive_Value_of_Indian_Foods.html?id=biFBAAAAYAAJ, https://www.sapnaonline.com/books/advanced-text-book-on-food-nutrition-vol-2-3473,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Fecal, Renal,
    Ref :-   Book : Martindale    Page : 2102   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA