Vitamin B3/Nicotinic acid (Niacin) is a Medicine belongs to Vitamin group whose information about Brand can be referenced from   Book : Martindale    Page : 2084   Edition : 38,    Page :   Edition : ,

  ►   Brandname : Nialip,Freederm,Niaspan,Nicam,Endur-acin,Niaspan,Nicotinex,Slo-Niacin,A to Z,Wellwoman tablet,Polybion

  ►  Strength : Tablet with 100  mg, Tablet with 250  mg, Tablet with 500  mg, Tablet with 1000  mg, Tablet (Extended Release Tablets) with 500  mg, Tablet (Extended Release Tablets) with 750  mg, Tablet (Extended Release Tablets) with 1000  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 633   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IM, IV,
Reference :-   Book : Martindale    Page : 2083   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Acne Topical 4 % Gel b.d.
2 Hyperlipidemia Oral 250 mg o.d.
3 Nicotinic acid deficiency Oral 500 mg Dose: Given daily in divided doses

Ref :-  Book : Martindale    Page : 2119   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Niacin deficiency Oral 50 300 mg

Ref :- Book : Nelson's textbook of Pediatrics    Page : 194   Edition : 19,
►  Side Effect : flushing, sensation of heat, faintness, pounding in the head, Dizziness, tachycardia, palpitations, dyspnoea, sweating, chills, dryness of the skin, pruritus, erythema, burning sensation, Irritation, hyperpigmentation, cramping, diarrhea, nausea, vomiting, anorexia, activation of peptic ulcer, amblyopia, jaundice, decrease in glucose tolerance, hyperglycemia, hyperuricemia, hypophosphataemia, reduction in platelet counts, prolongation of prothrombin time, arrhythmia, angioedema, insomnia, myalgia, hypotension, impairment of liver function,
Ref :-   Book : Martindale    Page : 2083,2084   Edition : 38,

►  Drug Interaction : Drug interaction of Vitamin B3/Nicotinic acid (Niacin) is with Insulin , Exenatide , Aspirin, Cholestyramine ,
Ref :-   Book : Martindale    Page : 2118   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  There may be an increased risk of myopathy or rhabdomyolysis when nicotinic acid is used with statins. Nicotinic acid may increase the requirements for insulin or oral hypoglycaemics. Aspirin may reduce the clearance of nicotinic acid. In vitro studies suggest that colestipol and colestyramine may reduce the availability of nicotinic acid, and some licensed product information recommends an interval of at least 4 to 6 hours between giving nicotinic acid and bile-acid binding resins.,
Ref :-   Book : Martindale    Page : 2084   Edition : 38,


►  Contraindication : peptic ulcer disease, Diabetes mellitus, hepatic impairment, renal impairment, hepatotoxicity,
Ref :-   Book : Martindale    Page : 2084   Edition : 38,
  ►  Mechanism of Action :   In adipose tissue, niacin inhibits the lipolysis of triglycerides by hormone-sensitive lipase, which reduces transport of free fatty acids to the liver and increases hepatic triglyceride synthesis,
Ref :-   Book : Goodman    Page : 900   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- peanut with same compound,

  ►  Pathway with its reference as follows :-
  • Nutritional Supplement --- (Gopalan, C. (2012). Nutritive value of Indian foods. National Institute of Nutrition ,ICMR.: Hyderabad 500007,INDIA. )

  •   ►  URL -- https://books.google.co.in/books/about/Nutritive_Value_of_Indian_Foods.html?id=biFBAAAAYAAJ,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Goodman    Page : 900   Edition : 12,


    ►    Plasma Half-life :
      Min value :-   1 hours,    Max value :-   NA
    Ref :-   Book : Basic & Clinical pharmacology    Page : 900   Edition : 12,

    ►    Peak Plasma Concentration :   Min value :-   0.5 hours,    Max value :-   1 hours,
    Ref :-   Book : Basic & Clinical pharmacology    Page : 900   Edition : 12,