Vitamin B3/Nicotinic acid (Niacin) is a Medicine belongs to Nutritional agent and vitamin group whose information about Brand can be referenced from   Book : Martindale    Page : 2084   Edition : 38      Page :   Edition :   

  ►   Brandname : Nialip, Freederm, Niaspan, Nicam, Endur-acin, Niaspan, Neasyn, Slo-Niacin, A to Z, Wellwoman tablet, Polybion
  ►  Strength : Tablet with 100 mg.  Tablet with 250 mg.  Tablet with 500 mg.  Tablet with 1000 mg.  Tablet (Extended Release Tablets) with 500 mg.  Tablet (Extended Release Tablets) with 750 mg.  Tablet (Extended Release Tablets) with 1000 mg.  Capsule with .  Injection with .  Oral solution with

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 633   Edition : 12   Martindale    Page : 2085   Edition : 38  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IM, IV
Reference :-   Book : Martindale    Page : 2083   Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Mild to moderate inflammatory acne Topical 4 % Gel b.d. For 8 weeks.
2 Hyperlipidemia Oral 250 mg Tablet/Capsule o.d. Increased every 4 to 7 days untill a dose of 1.5 to 2 gm daily.
3 Nicotinic acid deficiency Oral Up to 500 mg Tablet/Capsule but may also be given by the intramuscular route Or by slow intravenous injection. Dose: Given daily in divided doses

Ref :-  Book : Martindale    Page : 2083   Edition : 38  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Niacin deficiency Oral 50 300 mg

Ref :- Book : Nelson's textbook of Pediatrics    Page : 194   Edition : 19  
►  Side Effect : Flushing, Sensation of heat, Faintness, Pounding in the head, Dizziness, Tachycardia, palpitations, Dyspnoea, Sweating, Chills, Dryness of the skin, pruritus, Erythema, Burning sensation, Irritation, Hyperpigmentation, Cramping, Diarrhea, Nausea, Vomiting, Anorexia, Activation of peptic ulcer, Eye disorders including cystoid mascular oedema and toxic amblyopia, Jaundice, Decrease in glucose tolerance, Hyperglycemia, Hyperuricemia, Hypophosphataemia, Reduction in platelet counts, Prolongation of prothrombin time, Arrhythmia, Angioedema, Insomnia, Myalgia, Hypotension, Impairment of liver function, Oedema, Rashes, Cough
Ref :-   Book : Martindale    Page : 2083,2084   Edition : 38.   Martindale    Page : 2084   Edition : 38.  

►  Drug Interaction : Drug interaction of Vitamin B3/Nicotinic acid (Niacin) is with Statins, Oral Hypoglycemic Drugs, ,  Insulin , Exenatide , Aspirin, Cholestyramine , Colestipol
Ref :-   Book : Martindale    Page : 2118   Edition : 37.   Martindale    Page : 2084   Edition : 38.  


  ►    Mechanism of Drug Drug Interaction :  Nicotinic acid and statins can be given safely.There may be an increased risk of myopathy or rhabdomyolysis when nicotinic acid is used with statins. Nicotinic acid may increase the requirements for insulin or oral hypoglycaemics. Aspirin may reduce the clearance of nicotinic acid. In vitro studies suggest that colestipol and colestyramine may reduce the availability of nicotinic acid, and some licensedproduct information recommends an interval of at least 4 to 6 hours between giving nicotinic acid and bile-acid binding resins.
Ref :-   Book : Martindale    Page : 2084   Edition : 38.  


►  Contraindication : Peptic ulcer disease, Hepatic impairment, Acute coronary syndrome, patient with or predisposed to gout, or in those who consume large amounts of alcohol
Ref :-   Book : Martindale    Page : 2084   Edition : 38.  
  ►  Mechanism of Action :   In adipose tissue, niacin inhibits the lipolysis of triglycerides by hormone-sensitive lipase, which reduces transport of free fatty acids to the liver and increases hepatic triglyceride synthesis
Ref :-   Book : Goodman    Page : 900   Edition : 12.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- peanut with same compound.  

  ►  Pathway with its reference as follows :-
  • Nutritional Supplement --- (Gopalan, C. (2012). Nutritive value of Indian foods. National Institute of Nutrition ,ICMR.: Hyderabad 500007,INDIA. )

  •   ►  URL --
  • https://books.google.co.in/books/about/Nutritive_Value_of_Indian_Foods.html?id=biFBAAAAYAAJ .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal
    Ref :-   Book : Goodman    Page : 900   Edition : 12.  

    ►    Plasma Half-life :   Min value :-   1 hours,    Max value :-   NA
    Ref :-   Book : Goodman    Page : 900   Edition : 12.  

    ►    Peak Plasma Concentration :   Min value :-   30 minutes,    Max value :-   60 minutes.  
    Ref :-   Book : Goodman    Page : 900   Edition : 12.