Vitamin D/Calcitriol is a Medicine belongs to Nutritional agent and vitamin group whose information about Brand can be referenced from   Book :    Page :   Edition :    Martindale    Page : 2118   Edition : 38   Basic & Clinical pharmacology    Page : 786   Edition : 12  

  ►   Brandname : Gemcal, Alfa-Caps, Calcijex, Rocaltrol, A to Z, Wellwoman

  ►  Strength : Capsule with 0.25 mcg.  Capsule with 0.5 mcg.  Oral solution with 1 mcg/ml.  Injection with 1 mcg/ml.  Injection with 2 mcg/ml. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 786   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV, Topical
Reference :-   Book : Martindale    Page : 2114   Edition : 38  


Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Secondary hyperparathyroidism associated with chronic renal failure Oral 250 nanograms Capsule daily or on alternate days are given, increased if necessary, in steps of 250 nanograms at intervals of 2 to 4 weeks, to a usual dose of 0.5 to 1 microgram daily.
2 Secondary hyperparathyroidism associated with chronic renal failure IV 500 nanograms Injection Three times a week increased if necessary in steps of 250 to 500 nanograms at intervals of 2 to 4 weeks,
3 Moderate to severe secondary hyperparathyroidism in dialysis patients IV 0.5 4 Microgram Injection Given three times a week, increased if necessary in steps of 250 nanograms to 1 microgram at intervals of 2 to 4 weeks to a maximum of 8 micrograms given three times a week.
4 Postmenopausal osteoporosis 0.25 Microgram b.d.

Ref :-  Book : Martindale    Page : 2114   Edition : 38  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Vitamin D dependent Rickets, Hypophataemic rickets,Persistent hypocalcemia due to hypoparathyroidism or Pseudohypoparathyroidism 1 Month 12 Year Oral 15 nanogram/kg Capsule
2 Vitamin D dependent Rickets, Hypophataemic rickets,Persistent hypocalcemia due to hypoparathyroidism or Pseudohypoparathyroidism 12 Year 18 Year Oral 250 Microgram Capsule
3 Hypocalcaemia in dialysis patients 12 Year 18 Year IV 250 500 nanograms Injection

Ref :- Book : Martindale    Page : 2114   Edition : 38  
►  Side Effect : Hypercalcaemia include hypercalciuria, ectopic calcification, and renal and cardiovascular damage, Hyperphosphataemia, Hypersensitivity reactions have occurred, Skin irritation or contact dermatitis
Ref :-   Book : Martindale    Page : 2117   Edition : 38.  

►  Drug Interaction : Drug interaction of Vitamin D/Calcitriol is with Thiazide Diuretics , , , Corticosteroid , ,  Carbamazapine , Phenobarbital , Phenytoin , Primidone , Rifampicin , Isoniazid , Ketoconazole
Ref :-   Book : Martindale    Page : 2117   Edition : 38.  


  ►    Mechanism of Drug Drug Interaction :  There is an increased risk of hypercalcaemia if vitamin D is given with thiazide diuretics, calcium, or phosphate. Plasma-calcium concentrations should be monitored in such situations. Some antiepileptics may increase vitamin D requirements (e.g. carbamazepine, phenobarbital, phenytoin, and primidone). Rifampicin and isoniazid may reduce the effectiveness of vitamin D. Corticosteroids may counteract the effect of vitamin D. Ketoconazole may inhibit the metabolism of paricalcitol and these drugs should be used with caution together; care should be taken when using paricalcitol with other potent inhibitors of the cytochrome P450 isoenzyme CYP3A4.
Ref :-   Book : Martindale    Page : 2117   Edition : 38.  


►  Contraindication : Hypercalcaemia, Caution in infants, who may have increased sensitivity to its effects, and patients with renal impairment or calculi, or heart disease
Ref :-   Book : Martindale    Page : 2117   Edition : 38.  
  ►  Mechanism of Action :   Regulate gene transcription via the vitamin D receptor.
Ref :-   Book : Basic & Clinical pharmacology    Page : 785   Edition : 12.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- Fatty fish with same compound.   Beef with Another pathway.   Liver with Another pathway.   Cheese with Another pathway.   Egg yolk with Another pathway.   Milk with Another pathway.  

  ►  Pathway with its reference as follows :-
  • Vitamin D is a Nutritional Supplement. --- ( Gopalan, C., Rama Sastri, B., & Balasubramanian, S. (1971). Nutritive value of Indian foods. Hyderabad, India: National Institute of Nutrition, Indian Council of Medical Research. )
  • Vitamin D is a Nutritional Supplement. --- (Gopalan, C. (2012). Nutritive value of Indian foods. National Institute of Nutrition ,ICMR.: Hyderabad 500007,INDIA. )
  • Vitamin D is a Nutritional Supplement. --- (Gopalan, C., Rama Sastri, B., & Balasubramanian, S. (1971). Nutritive value of Indian foods. Hyderabad, India: National Institute of Nutrition, Indian Council of Medical Research. )

    •   ►  URL --
  • http://www.eeb.cornell.edu/biogeo/nanc/Food_Feed/table%201%20gopalan%20et%20al%201989.pdf .
    •
  • https://books.google.co.in/books?id=biFBAAAAYAAJ&q=nutritive+value+of+indian+foods&dq=nutritive+value+of+indian+foods&hl=en&sa=X&redir_esc=y .
    •


    DIETARY Substance Interactions

    ​   ► This Medicine interact with :- NA



    ContraIndication DIETARY Substance

    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal, Faecal, Biliary
    Ref :-   Book : Martindale    Page : 2118   Edition : 38.  

    ►    Plasma Half-life :   Min value :-   NA    Max value :-   NA

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA