Voriconazole is a Medicine belongs to Antifungal group whose information about Brand can be referenced from   Book : Martindale    Page : 599   Edition : 37,

  ►   Brandname : Vfend

  ►  Strength : Tablet with 50  mg, Tablet with 200  mg, Suspension with 40  mg/ml, Injection with 200  Mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 858   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV,
Reference :-   Book : Martindale    Page : 597   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Fungal infections Oral 400 mg Tablet b.d.
2 Fungal infections Oral 200 mg Tablet b.d.
3 Fungal infections IV 6 mg/kg Injection b.d.
4 Eye infections Topical 1 % Eye Drop

Ref :-  Book : Martindale    Page : 597   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Fungal infections 2 Year 14 Year > 50 kg IV 9 mg/kg Injection b.d.
2 Fungal infections 2 Year 14 Year Oral 9 mg/kg Suspension b.d.

Ref :- Book : Martindale    Page : 597   Edition : 38,
►  Side Effect : visual disturbances, fever, Rashes, nausea, vomiting, diarrhea, abdominal pain, headache, sepsis, peripheral oedema, fatalities, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, peripheral edema, photosensitivity reactions, anaphylaxis, chills, flu-like syndrome, asthenia, back pain, chest pain, injection syndrome, injection-site reactions, facial oedema, hypotension, sinusitis, altered liver function tests, jaundice, cheilitis, blood disorder, hypokalaemia, hypoglycemia, Dizziness, hallucinations, Confusion, Depression, anxiety, tremor, agitation, paraesthesia, pruritus, alopecia, exfoliative dermatitis, Acute renal failure, haematuria, respiratory disorders,
Ref :-   Book : Martindale    Page : 597   Edition : 37,

►  Drug Interaction : Drug interaction of Voriconazole is with Rifampicin , Carbamazapine , Astemizole, Cisapride , Pimozide , Quinidine , Terfenadine, caffeine , Sirolimus, Tacrolimus , Cyclosporine , Exenatide , Insulin , Suxamethonium/Succinylcholinechloride (Suxamethonium chloride) , , Fospropofol , Phenytoin , Rifabutin , Omeprazole ,
Ref :-   Book : Martindale    Page : 598   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Voriconazole is metabolised by cytochrome P450 isoenzymes CYP2C19, CYP2C9, and CYP3A4. Use of drugs that either inhibit or induce these isoenzymes may increase or decrease plasma concentrations of voriconazole, respectively. Rifampicin has been shown to decrease voriconazole plasma concentrations and a similar effect may be expected with carbamazepine or phenobarbital. Increased plasma concentrations of astemizole, cisapride, pimozide, quinidine, and terfenadine could be expected and concomitant use is contra-indicated because of the risk of cardiac arrhythmias including torsade de pointes. Use with ergot alkaloids such as ergotamine and dihydroergotamine is also contra-indicated because of the possible risk of ergotism. Increased plasma concentrations of sirolimus and tacrolimus have been noted; use with sirolimus is contra- indicated. Dose reductions may be needed for some statins, calciumchannel blockers, vinca alkaloids, and some benzodiazepines (such as midazolam and triazolam) if their plasma concentrations are increased. With omeprazole, the plasma concentration of both drugs may be increased. Voriconazole may inhibit metabolism of non-nucleoside reverse transcriptase inhibitors and they in turn may either inhibit the metabolism of voriconazole (e.g. delavirdine and efavirenz) or induce the metabolism of voriconazole (e.g. efavirenz and nevirapine). ,
Ref :-   Book : Martindale    Page : 598   Edition : 37,


►  Contraindication : renal failure, hepatic impairment, inducer of cytochrome P450 isoenzymes CYP2C19, CYP2C9, and CYP3A4, , Arrhythmia,
Ref :-   Book : Martindale    Page : 597-598   Edition : 37, Martindale    Page : 597-598   Edition : 38,
  ►  Mechanism of Action :   Inhibit ultimate conversion of lanosterol to ergosterol by inhibiting 14α-sterol demethylase; the resulting decrease in ergosterol synthesis and accumulation of 14α-methyl sterols disrupt the tightly packed acyl chains of the phospholipids in the fungal membrane. ,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 627   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Citrus fruit with Another pathwayAnother pathway, Citrus fruit with Another pathwayAnother pathway, Citrus fruit with Another pathwayAnother pathway, Citrus fruit with Another pathwayAnother pathway, Angeer with Another pathway,

  ►  Pathway with its reference as follows :-
  • Citrus essential oil have --- (L, J. (2014). Antifungal Activity of Citrus Essential Oils. J Agric Food Chem. )
  • Citrus essential oils --- ( L, J. (2014). Antifungal Activity of Citrus Essential Oils. J Agric Food Chem )
  • Citrus essential oil have --- (L, J. (2014). Antifungal Activity of Citrus Essential Oils. J Agric Food Chem. )
  • Citrus essential oils --- ( L, J. (2014). Antifungal Activity of Citrus Essential Oils. J Agric Food Chem )
  • Citrus essential oils --- ( L, J. (2014). Antifungal Activity of Citrus Essential Oils. J Agric Food Chem.. )
  • Citrus essential oils --- ( L, J. (2014). Antifungal Activity of Citrus Essential Oils. J Agric Food Chem.. )
  • Citrus essential oils --- ( L, J. (2014). Antifungal Activity of Citrus Essential Oils. J Agric Food Chem.. )
  • Citrus essential oils --- ( L, J. (2014). Antifungal Activity of Citrus Essential Oils. J Agric Food Chem.. )
  • 6-o-acyl-beta-d-glucosyl-beta-sitosterols.found in fig or anjeer have anticancer property. --- (Joseph, Baby. "Pharmacognostic And Phytochemical Properties Of Ficus Carica Linn –An Overview". International Journal of PharmTech Research 3.1 (2017): 08-12,. Print. )

  •   ►  URL -- http://www.ncbi.nlm.nih.gov/pubmed/24628448, , http://sphinxsai.com/Vol.3No.1/pharm_jan-mar11/pdf/JM11(%20PT=03)%2008-12.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- ST JOHNS WORT with Voriconazole contraindicated with st joth wort.,

      ►  Reference :-
  • Driver, S. (2009). Stockleys Herbal Medicines Interactions. Royal pharmaceutical Society of Great Britain: Pharmaceutical press.

  •   ►  URL -- https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf,

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Goodman    Page : 1580   Edition : 12,


    ►    Plasma Half-life :   Min value :-   6 hours,    Max value :-   NA
    Ref :-   Book : Goodman    Page : 1580   Edition : 12,


    ►    Peak Plasma Concentration :   Min value :-   1 nhours,    Max value :-   2 hours,
    Ref :-   Book : Martindale    Page : 598   Edition : 37,