Warfarin is a Medicine belongs to Anticoagulant group whose information about Brand can be referenced from   Book : Martindale    Page : 1572   Edition : 37,

  ►   Brandname : Coumadin,Marevan,Uniwarfin

  ►  Strength : Tablet with 1  mg, Tablet with 2  mg, Tablet with 2.5  mg, Tablet with 3  mg, Tablet with 4  mg, Tablet with 5  mg, Tablet with 6  mg, Tablet with 7.5  mg, Tablet with 10  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 617   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV,
Reference :-   Book : Martindale    Page : 1571   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Anticoagulant Oral 10 mg

Ref :-  Book : Martindale    Page : 1571   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Anticoagulant >1 Day >28 Day Oral 200 micrograms/kg
2 Anticoagulant Oral 200 micrograms/kg
3 Anticoagulant 18 Year Oral 200 micrograms/kg

Ref :- Book : Martindale    Page : 1572   Edition : 37,
►  Organ Affected Liver Disease (Protein binding reduced)  

Precaution :- If a Patient is using 'Warfarin' drug in  Cardiac Disease  disease, then Please Use after 1st trimester before 36 weeks, Dont use within 48 hrs of delivery .

Precaution :- If a Patient is using 'Warfarin' drug in  Venous Thrombosis  disease, then Please Within 48 hours of delivery and in first trimester or after 36 weeks. .

Precaution :- If a Patient is using 'Warfarin' drug in  Antiphospholipid syndrome  disease, then Please Within 48 hours of delivery and in first trimester or after 36 weeks. .

Precaution :- If a Patient is using 'Warfarin' drug in atrial fibrillation disease, then Please use with caution   if he ever suffered from Tropical Sprue disease.
Precaution :- If a Patient is using 'Warfarin' drug in atrial fibrillation disease, then Please use with caution   if he ever suffered from Intracranial Hemorrhage disease.
►  Side Effect : Haemorrhage, hematomas, anaemia, skin necrosis, purple discolouration of toes, alopecia, fever, vomiting, nausea, diarrhea, jaundice, hepatic dysfunction, Pancreatitis, teratogenic, fetal embryopathy, nasal hypoplasia, abortion, hypersensitivity reactions, still births,
Ref :-   Book : Martindale    Page : 1564   Edition : 37,

►  Drug Interaction : Drug interaction of Warfarin is with flowering plant,  acetomenaphthone, Zonisamide , aminoglutethimide , Norgestrienone , Bosentan , Carbamazapine , dichloralphenazone, Ethchlorvynol, Glutethimide, Griseofulvin , nafcillin, phytomenadione, Rifampicin , Allopurinol , Amiodarone , Aspirin, Cefamandole, Cimetidine , Clofibrate, Chloral hydrate, cotrimoxazole, Danazol, dextropropoxyphene, dextrothyroxine, Dipyridamole , Disulfiram, Erythromycin , Etacrynic acid, Ethylestrenol, Fluconazole , Glucagon , Itraconazole , Ketoconazole , Metronidazole , Miconazole, Norethandrolone, Ropivacaine , Oxymetholone , Quinidine , Stanozolol, Sulfinpyrazone, Tamoxifen citrate , Telithromycin, , Tramadol , triclofos sodium ,
Ref :-   Book : Martindale    Page : 1565   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Drugs generally recognised as diminishing the effects of oral anticoagulants are included in the following list. acetomenaphthone, alcohol (chronic ingestion without liver impairment), aminoglutethimide, barbiturates, bosentan, carbamazepine, dichloralphenazone, ethchlorvynol glutethimide, griseofulvin, nafcillin, phytomenadione, rifampicin, St John’s wort.............Drugs recognised or generally reported as enhancing oral anticoagulants are included in the following list. alcohol (acute ingestion or chronic ingestion with liver impairment), allopurinol, amiodarone, aspirin, cefamandole, chloramphenicol, cimetidine, clofibrate, cloral hydrate, co-trimoxazole, danazol, dextropropoxyphene, dextrothyroxine, dipyridamole, disulfiram, erythromycin, etacrynic acid, ethylestrenol, fluconazole, glucagon, itraconazole, ketoconazole, metronidazole, miconazole, norethandrolone, NSAIDs, oxymetholone, quinidine, stanozolol, sulfinpyrazone, tamoxifen, telithromycin, thyroid agents, tramadol, triclofos sodium. ,
Ref :-   Book : Martindale    Page : 1565   Edition : 37,


►  Absolute Contraindication : Patients at serious risk of haemorrhage   haemorrhagic blood disorder   peptic ulcer disease   severe wounds   cerebrovascular disorders   bacterial endocardititis   severe hepatic and renal impairment   pregnancy.   

►  Contraindication : Haemrrhagic disorder, peptic ulcer disease, severe wound, cardiovascular or cerebrovascular disorder, hepatic impairment, renal impairment, severe hypertension, pregnancy,
Ref :-   Book : Martindale    Page : 1565   Edition : 37,
  ►  Mechanism of Action :   Inhibit hepatic epoxide reductase that catalyzes the regeneration of reduce vitamin k, which is required for synthesis of biologically active coagulation factors II, , VII, IX, and anticoagulant proteins C and S,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 397   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- with Another pathwaysame pathway, with Another pathwaysame pathway, Melilotus officinalis i.e.aspurk. with same compound, Melilotus alba i.e.Safed Ban Methi i.e. Sweet clover with same compound, Licorice Root with same compound, Galium odoratum i.e.woodroff with same compound, lavender with same compound,

  ►  Pathway with its reference as follows :-
  • It is an essential Cofactor for the gamma Carboxylase enzymes which catalyze the posttranslational gamma carboxylation of glutamic acid residuce in inactive hepatic precursors of coagulation factor II (prothrombin), VII, IX and X. Gamma-Carboxylation --- (19. Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart. )
  • It is an essential Cofactor for the gamma Carboxylase enzymes which catalyze the posttranslational gamma carboxylation of glutamic acid residuce in inactive hepatic precursors of coagulation factor II (prothrombin), VII, IX and X. Gamma-Carboxylation --- (19. Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart. )
  • It is an essential Cofactor for the gamma Carboxylase enzymes which catalyze the posttranslational gamma carboxylation of glutamic acid residuce in inactive hepatic precursors of coagulation factor II (prothrombin), VII, IX and X. Gamma-Carboxylation --- (19. Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart. )
  • It is an essential Cofactor for the gamma Carboxylase enzymes which catalyze the posttranslational gamma carboxylation of glutamic acid residuce in inactive hepatic precursors of coagulation factor II (prothrombin), VII, IX and X. Gamma-Carboxylation --- (19. Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart. )
  • Warferin or Coumarin Naturally optain from Melilotus officinalis. --- ( Pirmohamad, Munir. "Warfarin: Almost 60 Years Old And Still Causing Problems". Br J Clinical Pharmacol 62.5 (2006): 509-511. Web. 24 Jan. 2017. )
  • Warferin or Coumarin Naturally optain from Melilotus alba. --- (Pirmohamad, Munir. "Warfarin: Almost 60 Years Old And Still Causing Problems". Br J Clinical Pharmacol 62.5 (2006): 509-511. Web. 24 Jan. 2017. )
  • warferin or coumarin naturally optain from licoric --- (Pirmohamad, Munir. "Warfarin: Almost 60 Years Old And Still Causing Problems". Br J Clinical Pharmacol 62.5 (2006): 509-511. Web. 24 Jan. 2017. )
  • warferin or coumarin naturally optain from woodruff. --- (Pirmohamad, Munir. "Warfarin: Almost 60 Years Old And Still Causing Problems". Br J Clinical Pharmacol 62.5 (2006): 509-511. Web. 24 Jan. 2017. )
  • warferin or coumarin naturally optain from woodruff. --- (Pirmohamad, Munir. "Warfarin: Almost 60 Years Old And Still Causing Problems". Br J Clinical Pharmacol 62.5 (2006): 509-511. Web. 24 Jan. 2017. )

  •   ►  URL -- http://197.14.51.10:81/pmb/AGROALIMENTAIRE/Handbook%20of%20Nutrition.pdf, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1885167/,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- CHITOSAN with Dietary Substance is Drug Enhancer, IRON with Decrease in Nutrient Level, MAGNESIUM with Decrease in Nutrient Level, ZINC with Decrease in Nutrient Level, VITAMIN C with Decrease in Nutrient Level, COQ10 with Decrease in Nutrient Level, COQ10 with Dietary Substance is Drug Inhibitor, CINCONA BARK with Dietary Substance is Drug Enhancer, VITAMIN D with Increase in Nutrient Level, VITAMIN E with Increase in Nutrient Level, VITAMIN K with Dietary Substance is Drug Inhibitor,

      ►  Reference :-
  • Williamson, E. (2009). Stockley's Herbal Medicines Interaction .. London: Pharmacutical press.
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf, http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf, abc, http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf, http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf ,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- GINGER (ZINGIBER OFFICINALE) with inhibit platetet aggregation , GREEN TEA with Green tea per day developed with this drug developed too thick blood and block the effect of drug ., GARLIC with Garlic increased bleeding with this drug . , GARLIC with It may interact with warfarin and may cause bleeding ., CELERY with It may interact with warfarin and may cause bleeding ., CHAMMOMILA with It may interact with warfarin and may cause bleeding ., CHAMMOMILA with It may interact with warfarin and may cause bleeding ., FENUGREEK SEED with It may interact with warfarin and may cause bleeding ., MAKANDI with It may interact with warfarin and may cause bleeding ., MAKANDI with It may interact with warfarin and may cause bleeding ., RED CLOVE with It may interact with warfarin and may cause bleeding ., DONG QUAI (FEMALE GINSENG) with It may interact with warfarin and may cause bleeding ., RUE with It may interact with warfarin and may cause bleeding ., QUASSIA with It may interact with warfarin and may cause bleeding ., FEVER FEW with Fever few inhibit platelet aggregation & increase the risk o f bleeding .bg, PINEAPPLE with Bromelain in pineapple enhance the action of anticoagulants., PAPAYA with Papain ,an anzyme found in papaya,incerased warferin activity.person taking warferin should avoid papain supplement., ASHWAGANDHA with Panex ginseng associated with a decrease in warferin activity., CRANBERRY with cranberry juice increases the activity of drug ,by inhibiting the breakdown of warferin in the body., DANSHEN with Danchan increases the activity of drug ., LYCIUM BARBARUM with Lycium barbarum interfere with effect of warferin , QUILINGGAO with Quilinggao increased the action of warferin & contribute to a bleeding episode., REISHI(GANODERNMA LUCIDUM) with Reishi increse bleeding time,so not given for those taking anticoagulant.,

      ►  Reference :-
  • Driver, S. (2009). Stockleys Herbal Medicines Interactions. Royal pharmaceutical Society of Great Britain: Pharmaceutical press.
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Williamson, E. (2009). Stockley's Herbal Medicines Interaction .. London: Pharmacutical press.
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf , http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf, http://www.foodandnutritionjournal.org/, https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf, http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,

    ►   Route of Elimination :   Biliary, Renal,
    Ref :-   Book : Martindale    Page : 1571   Edition : 37,


    ►    Plasma Half-life :   Min value :-   37 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1571   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   8 hours,
    Ref :-   Book : Goodman    Page : 862   Edition : 12,