Xipamide is a Medicine belongs to Thiazide Diuretics group whose information about Brand can be referenced from   Book : Martindale    Page : 1536   Edition : 38,

  ►   Brandname : Diurexan,Xipamid

  ►  Strength : Tablet with nf  ,

Reference of this Medicine for its Strength can be taken from   Book :    Page :    Edition : ,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 1572   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 hypertension Oral 20 mg Tablet Dose: Given daily.
2 Oedema Oral 40 mg Tablet Dose: Given daily.

Ref :-  Book : Martindale    Page : 1573   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : NA

►  Drug Interaction : Drug interaction of Xipamide is with Quinidine , Ropinirole , Propranolol , , Insulin , Aminophylline , Diazoxide , digitalis, Felbamate, Sugammadex , , Ropivacaine , sexagliptin , Verapamil , Amphotericin B ,
Ref :-   Book : Goodman    Page : 689   Edition : 12,


  ►    Mechanism of Drug Drug Interaction :  Thiazide diuretics may diminish the effects of anticoagulants, uricosuric agents used to treat gout, sulfonylureas, and insulin and may increase the effects of anesthetics, diazoxide, digitalis glycosides, lithium, loop diuretics, and vitamin D. The effectiveness of thiazide diuretics may be reduced by NSAIDs, nonselective or selective COX-2 inhibitors, and bile acid sequestrants (reduced absorption of thiazides). Amphotericin B and corticosteroids increase the risk of hypokalemia induced by thiazide diuretics. Prolongation of the QT interval by quinidine can lead to the development of polymorphic ventricular tachycardia (torsades de pointes) owing to triggered activity originating from early after-depolarizations. Torsades de pointes may deteriorate into fatal ventricular fibrillation. Hypokalemia increases the risk of quinidine-induced torsades de pointes, and thiazide diuretics cause hypokalemia,
Ref :-   Book : Martindale    Page : 1572   Edition : 37,


►  Contraindication : heart failure, hepatic cirrhosis, hypersensitive to sulfonamides, renal failure,
Ref :-   Book : Goodman    Page : 689   Edition : 12,
  ►  Mechanism of Action :   Decreases NaCl reabsorption in the distal convoluted tubule.,
Ref :-   Book : Basic & Clinical pharmacology    Page : 222   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Watermelon with Another pathway, Tea with Another pathway,

  ►  Pathway with its reference as follows :-
  • Watermelon having high water content so it act as diuretic . --- ( Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )
  • Tea having active constituent caffeine which act as Diuretic . --- ( Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html, http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 1572   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   5 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1572   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   1 hour,    Max value :-   2 hours,
    Ref :-   Book : Martindale    Page : 1572   Edition : 38,