Zafirlukast is a Medicine belongs to leukotriene antagonist/drug used in asthma group whose information about Brand can be referenced from   Book : Martindale    Page : 1266   Edition : 37,

  ►   Brandname : Zuvair,Accolate

  ►  Strength : Tablet with 10  mg, Tablet with 20  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 328   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Basic & Clinical pharmacology    Page : 328   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Chronic asthma Oral 20 mg Tablet b.d.

Ref :-  Book : Martindale    Page : 1266   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Chronic asthma 5 Year 11 Year Oral 10 mg Tablet b.d.

Ref :- Book : Martindale    Page : 1266   Edition : 37,
►  Side Effect : abdominal pain, angioedema, arthralgia, malaise, myalgia, Dizziness, fever, insomnia, elevation of liver enzymes, pruritus, Urticaria, Churg-Strauss syndrome,
Ref :-   Book : Martindale    Page : 1265   Edition : 37,

►  Drug Interaction : Drug interaction of Zafirlukast is with Warfarin , Erythromycin , Terfenadine, Theophylline , Aspirin,
Ref :-   Book : Goodman    Page : 1265   Edition : 12,


  ►    Mechanism of Drug Drug Interaction :  Zafirlukast is metabolised by hepatic cytochrome P450, specifically the CYP2C9 isoenzyme, and has been shown to inhibit the activity of isoenzymes CYP2C9 and CYP3A4. Patients receiving warfarin may develop prolongation of the prothrombin time and anticoagulant dosage should be adjusted accordingly. Erythromycin, terfenadine, and theophylline may reduce plasma concentrations of zafirlukast; zafirlukast has rarely been reported to increase plasma-theophylline concentrations. Increased plasma concentrations of zafirlukast have been seen when given with high doses of aspirin.,
Ref :-   Book : Martindale    Page : 1265   Edition : 37,


►  Contraindication : asthma, hepatic cirrhosis, hepatic impairment,
Ref :-   Book : Martindale    Page : 1265   Edition : 37,
  ►  Mechanism of Action :   Zafirlukast is a selective and competitive antagonist of the leukotriene C4, D4, and E4 receptors (p.1108), stimulation of which by circulating leukotrienes is thought to play a role in the pathogenesis of asthma.,
Ref :-   Book : Martindale    Page : 1266   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Aloe vera with same pathway,

  ►  Pathway with its reference as follows :-
  • Leukotrienes inhibitor . --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- WILLOW BARK with Willow bark contains salicin,a substance similar to aspirin .people avoid combinig willow bark with drug due to increase side effect.,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,

    ►   Route of Elimination :   Fecal, Hepatic (Metabolism),
    Ref :-   Book : Martindale    Page : 1266   Edition : 37,


    ►    Plasma Half-life :   Min value :-   10 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1266   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   3 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1266   Edition : 37,