Zidovudine is a Medicine belongs to Antiviral group whose information about Brand can be referenced from   Book : Martindale    Page : 1010   Edition : 37,

  ►   Brandname : Zidomax,Zidovex,Retrovir

  ►  Strength : Capsule with 100  mg, Capsule with 250  mg, Solution with 50/5  mg/ml, Injection with 10  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 1010   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 1010   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 HIV infection and AIDS Oral 500 600 mg Dose: Given daily in 2 or 3 divided doses.
2 HIV infection and AIDS IV infusion 2 4 mg/ml Injection
3 prevention of maternal-fetal HIV transmission Oral 100 mg Dose: Given 5 times daily.

Ref :-  Book : Martindale    Page : 1012   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 HIV infection 4 kg up to 9 kg Oral 12 mg/kg Solution b.d.
2 HIV infection 9 kg 30 kg Oral 9 mg/kg Solution b.d.
3 HIV infection 30 kg or more Oral 250 300 mg Solution b.d.
4 HIV infection 8 to 14 kg Oral 100 mg Capsule b.d.
5 HIV infection 14 to 21 kg Oral 100 mg Capsule
6 HIV infection Oral 200 mg Capsule
7 HIV infection 22 to 28 kg Oral 200 mg Capsule b.d.
8 HIV infection 28 to 30 kg Oral 200 250 mg Capsule b.d.
9 HIV infection 30 kg or more Oral 250 300 mg Capsule b.d.
10 HIV infection IV infusion 80 160 mg/m2 Injection
11 prevention of maternal-fetal HIV transmission Oral 2 mg/kg
12 prevention of maternal-fetal HIV transmission >1 Day > 28 Day IV infusion 1.5 mg/kg Injection

Ref :- Book : Martindale    Page : 1013   Edition : 37,
►  Side Effect : fatigue, malaise, myalgia, anorexia, headache, insomnia, Bone marrow suppression, haematological toxicities, anaemia, leukopenia, neutropenia, Immune reconstitution syndrome, Osteonecrosis, Abnormal pigmentation of the skin, abnormal pigmentation of nails, myopathy,
Ref :-   Book : Martindale    Page : 1010   Edition : 37,

►  Drug Interaction : Drug interaction of Zidovudine is with Amphotericin B , cotrimoxazole, Dapsone , Doxorubicin, Flucytosine , Ganciclovir , Interferon, Pentamidine , Pyrimethamine , , Misoprostol ,
Ref :-   Book : Martindale    Page : 1010.1   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Drugs that undergo glucuronidation may delay the metabolism of zidovudine but few of these appear to produce clinically important increases in zidovudine plasma concentrations. Bone marrow supression directly with Zidovudine occurs when given with other immunosupressants and myelosupressants.There may be an increased risk of haematotoxicity during use of zidovudine with NSAIDs,
Ref :-   Book : Martindale    Page : 1010   Edition : 37,


►  Contraindication : CV disease, granulocytopenia , Pre-existing anaemia, severe liver disease,
Ref :-   Book : Martindale    Page : 1010   Edition : 37,
  ►  Mechanism of Action :   Zidovudine is converted intracellularly in stages to the triphosphate via thymidine kinase and other kinases. This triphosphate halts the DNA synthesis of retroviruses, including HIV, through competitive inhibition of reverse transcriptase and incorporation into viral DNA,
Ref :-   Book : Martindale    Page : 1010   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Alpine cranberry with Another pathway, Bhuiamla with Another pathway,

  ►  Pathway with its reference as follows :-
  • Phyllanthin Niruside have anti viral property --- (Kokate, c. & Purohit, A. (2016). pharmacognosy. nirali prakashan. )
  • Phyllanthin Niruside have anti HIV. --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html, http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- RIBOFLAVIN with Decrease in Nutrient Level,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- PHYLLIUM with Phyllium should not be used within 2 hours of taking medication .,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,

    ►   Route of Elimination :   Biliary,
    Ref :-   Book : Martindale    Page : 1010   Edition : 37,


    ►    Plasma Half-life :   Min value :-   3 hours,    Max value :-   4 hours,
    Ref :-   Book : Martindale    Page : 1010   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   1 hour,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1010   Edition : 37,