Zileuton is a Medicine belongs to leukotriene inhibitors group whose information about Brand can be referenced from   Book : Martindale    Page : 1267   Edition : 37,

  ►   Brandname : Zyflo

  ►  Strength : Tablet with 600  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 328   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Basic & Clinical pharmacology    Page : 328   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Chronic asthma Oral 600 mg Tablet q.i.d. Dose: Given as immediate-release preparation.
2 Chronic asthma Oral 1.2 gm Tablet b.d. Dose:Given as controlled-release formulation.

Ref :-  Book : Martindale    Page : 1267   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Allergic disorders Oral 600 mg Tablet

Ref :- Book : Nelson's textbook of Pediatrics    Page : 794   Edition : 19,
►  Side Effect : gastrointestinal disturbance, pharyngolaryngeal pain, headache, hypersenstivity, myalgia, rash, sinusitis, Urticaria, leucopenia,
Ref :-   Book : Martindale    Page : 1266   Edition : 37,

►  Drug Interaction : Drug interaction of Zileuton is with Propranolol , Terfenadine, Theophylline , Warfarin ,
Ref :-   Book : Martindale    Page : 1266   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Zileuton has been reported to impair the metabolism of some drugs metabolised via hepatic cytochrome P450 enzymes, including propranolol, terfenadine, theophylline, and warfarin.,
Ref :-   Book : Martindale    Page : 1266   Edition : 37,


►  Contraindication : hepatic disease, elevated liver enzyme,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 764   Edition : 3,
  ►  Mechanism of Action :   Inhibits 5-lipoxygenase, which catalyzes the formation of leukotrienes from arachidonic acid,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 764   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Long peper with Another pathway, Long peper with Another pathway,

  ►  Pathway with its reference as follows :-
  • Effective in the treatment of asthma . --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )
  • Effective in the treatment of asthma . --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )
  • Effective in the treatment of asthma . --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )
  • Effective in the treatment of asthma . --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- HIGH PROTEIN with Dietary Substance is Drug Inhibitor,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- CAFFEINE with Caffeine increase feeling of anxiety and nervousness.,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,

    ►   Route of Elimination :   Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 1267   Edition : 37,


    ►    Plasma Half-life :   Min value :-   2.5 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1267   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1267   Edition : 37,