Zolmitriptan is a Medicine belongs to 5- HT Agonists group whose information about Brand can be referenced from   Book : Martindale    Page : 683   Edition : 37,

  ►   Brandname : Zomig

  ►  Strength : Tablet with 2.5  mg, Tablet with 5  mg, Nasal Drop with 5  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 292   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, intranasal,
Reference :-   Book : Martindale    Page : 683   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Migraine Oral 2.5 mg Tablet
2 Migraine nasal 5 mg drops Dose: Given as a single dose into one nostril.

Ref :-  Book : Martindale    Page : 683   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Migraine Oral 2.5 5 mg Tablet
2 Migraine nasal 2.5 5 mg drops

Ref :- Book : Nelson's textbook of Pediatrics    Page : 2044   Edition : 19,
►  Side Effect : Dizziness, drowsiness, fatigue, flushing, dyspnoea, nausea, vomiting, hypoaesthesia, Ischemia, paraesthesia, Pain or sensations of heaviness,
Ref :-   Book : Martindale    Page : 679, 682   Edition : 37,

►  Drug Interaction : Drug interaction of Zolmitriptan is with Methysergide, Fluvoxamine, Ciprofloxacin ,
Ref :-   Book : Martindale    Page : 680,682   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Sumatriptan and other serotonin (5-HT1) agonists should not be given with ergotamine or related compounds (including methysergide) since there is an increased risk of vasospastic reactions. Reduction in zolmitriptan dosage is anticipated if it is given with drugs, such as fluvoxamine and ciprofloxacin, that inhibit the cytochrome P450 isoenzyme CYP1A2. ,
Ref :-   Book : Martindale    Page : 680,682   Edition : 37,


►  Contraindication : Arrhythmia, hepatic impairment, Wolff-Parkinson-White syndrome,
Ref :-   Book : Martindale    Page : 682   Edition : 37,
  ►  Mechanism of Action :   It is a selective serotonin agonist that acts at 5-HT1 receptors and produces vasoconstriction of cranial arteries.,
Ref :-   Book : Martindale    Page : 681   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Ginger (Zingiber officinale) with Another pathway,

  ►  Pathway with its reference as follows :-
  • Effective in the treatment of migran . --- (Kokate, C. K, A.P. Purohit, and S.B. Gokhale. Pharmacognosy. 1st ed. Mumbai: Nirali Prakashan, 2014. Print. )

  •   ►  URL -- https://books.google.co.in/books?id=KwYIsLRyDp4C&pg=SL1-PA102&lpg=SL1-PA102&dq=pharmacognosy+by+kokate&source=bl&ots=8hQsNxkE_6&sig=bmgn5pVpcZq0uZYw-x5pBtypxXs&hl=en&sa=X&ved=0ahUKEwiqrd6slarQAhVBuo8KHfrSCPYQ6AEIKzAD#v=onepage&q=pharmacognosy%20by%20kokate&f=false,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- with Dietary Substance is Drug Inhibitor,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- with It increase the side effect of the drug ., 5 HTP(5-HYDROXYTRYPTOPHAN) with 5-hydroxytryptophan increase drug induce side effect.,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,

    ►   Route of Elimination :   Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 683   Edition : 37,


    ►    Plasma Half-life :   Min value :-   2.5 hours,    Max value :-   3 hours,
    Ref :-   Book : Martindale    Page : 683   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   1.5 hours,    Max value :-   3 hours,
    Ref :-   Book : Martindale    Page : 682   Edition : 37,