Zolmitriptan is a Medicine belongs to antimigraine drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 683   Edition : 37  

  ►   Brandname : Zomig; Asco Top
  ►  Strength : Tablet with 2.5 mg.  Tablet with 5 mg.  Nasal Drop with 5 mg.  Disintegrating tablets with 2.5 mg. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 292   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, intranasal
Reference :-   Book : Martindale    Page : 683   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Migraine Oral 2.5 mg Tablet
2 Migraine nasal 5 mg drops Dose: Given as a single dose into one nostril.

Ref :-  Book : Martindale    Page : 683   Edition : 37  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Migraine Oral 2.5 5 mg Tablet
2 Migraine nasal 2.5 5 mg drops

Ref :- Book : Nelson's textbook of Pediatrics    Page : 2044   Edition : 19  
►  Side Effect : Dizziness, Flushing, Weakness, Drowsiness, Fatigue, Nausea, Vomiting, Dyspnoea, Sensory disturbances, Paraesthesia, Hypoaesthesia, Pain or sensations of heaviness, heat or cold, pressure, or tightness
Ref :-   Book : Martindale    Page : 679, 682   Edition : 37.  

►  Drug Interaction : Drug interaction of Zolmitriptan is with Cimetidine , Fluvoxamine, Ciprofloxacin
Ref :-   Book : Martindale    Page : 682   Edition : 37.  


  ►    Mechanism of Drug Drug Interaction :  Zolmitriptan undergoes hepatic metabolism, mainly mediated by cytochrome P450 isoenzyme CYP1A2 and also involving monoamine oxidase type A. It is recommended that the maximum dose of zolmitriptan in 24 hours should be reduced in patients receiving receiving cimetidine, a general P450 inhibitor. A similar reduction in zolmitriptan dosage is anticipated if it is given with drugs, such as fluvoxamine and ciprofloxacin, that inhibit the cytochrome P450 isoenzyme CYP1A2. Opinion varies on the use of zolmitriptan with inhibitors of monoamine oxidase type A such as moclobemide. In the UK licensed product information recommends that the maximum dose of zolmitriptan should be reduced when used with inhibitors of monoamine oxidase type A , whereas in the USA such combinations are contra-indicated.
Ref :-   Book : Martindale    Page : 682   Edition : 37.  


►  Contraindication : Arrhythmia, Hepatic impairment, Wolff-Parkinson-White syndrome, Severe hepatic impairment, Severe renal disease, History of ischemic disease, History of vasospastic coronary artery disease (including history of stroke or transient ischemic attacks), Cerebrovascular disease, Peripheral vascular disease, Hemiplegic migraines, Basilar migraines, cardiovascular disease, Ischemic bowel diseases, Uncontrolled hypertension
Ref :-   Book : Martindale    Page : 682   Edition : 37.   Goodman    Page : 346   Edition : 12.  
  ►  Mechanism of Action :   It is a selective serotonin agonist that acts at 5-HT1 receptors and produces vasoconstriction of cranial arteries.
Ref :-   Book : Martindale    Page : 681, 683   Edition : 37.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Ginger (Zingiber officinale) with Another pathway.  

  ►  Pathway with its reference as follows :-
  • Effective in the treatment of migran . --- (Kokate, C. K, A.P. Purohit, and S.B. Gokhale. Pharmacognosy. 1st ed. Mumbai: Nirali Prakashan, 2014. Print. )

  •   ►  URL --
  • https://books.google.co.in/books?id=KwYIsLRyDp4C&pg=SL1-PA102&lpg=SL1-PA102&dq=pharmacognosy+by+kokate&source=bl&ots=8hQsNxkE_6&sig=bmgn5pVpcZq0uZYw-x5pBtypxXs&hl=en&sa=X&ved=0ahUKEwiqrd6slarQAhVBuo8KHfrSCPYQ6AEIKzAD#v=onepage&q=pharmacognosy%20by%20kokate&f=false .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- NA 5 HTP(5-HYDROXYTRYPTOPHAN) with 5-hydroxytryptophan increase drug induce side effect..  

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf

    ►   Route of Elimination :   Hepatic (Metabolism), Renal, Faecal
    Ref :-   Book : Martindale    Page : 683   Edition : 37.   Martindale    Page : 682   Edition : 37.  

    ►    Plasma Half-life :   Min value :-   2.5 hours,    Max value :-   3 hours.  
    Ref :-   Book : Martindale    Page : 682   Edition : 37.  

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA