Zonisamide is a Medicine belongs to Antiseizure drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 561   Edition : 37  

  ►   Brandname : Zonegran
  ►  Strength : Tablet with 25 mg.  Tablet with 50 mg.  Tablet with 100 mg. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 427   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Basic & Clinical pharmacology    Page : 427   Edition : 12  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Epilepsy Oral 50 mg o.d.
2 Epilepsy Oral 50 mg Tablet Dose: Given daily in 2 divided doses.
3 Parkinson’s disease Oral 25 mg Tablet o.d.

Ref :-  Book : Martindale    Page : 561   Edition : 37  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Abdominal pain, Anorexia, Diarrhea, Nausea, Agitation, Ataxia, Depression, Headache, Agitation, Somnolence, Stevens-Johnson syndrome, Toxic epidermal necrolysis
Ref :-   Book : Martindale    Page : 560   Edition : 37.  

►  Drug Interaction : Drug interaction of Zonisamide is with Carbamazapine , Phenytoin , Phenobarbital , Valproic acid(sodium valproate)
Ref :-   Book : Martindale    Page : 561   Edition : 37.  


  ►    Mechanism of Drug Drug Interaction :  Use with drugs that induce or inhibit the cytochrome P450 isoenzyme CYP3A4 may alter plasma concentrations of zonisamide
Ref :-   Book : Martindale    Page : 561   Edition : 37.  


►  Contraindication : Renal impairment, Nephrolithiasis, History of hypersensitivity to sulfonamides
Ref :-   Book : Martindale    Page : 561   Edition : 37.  
  ►  Mechanism of Action :   Zonisamide is a sulfonamide derivative. Its primary site of action appears to be the Na+ channel; it also acts on T-type voltage-gated Ca2+ channels.
Ref :-   Book : Basic & Clinical pharmacology    Page : 417   Edition : 12.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Behen root with Another pathway.   Scullcap with Another pathway.  

  ►  Pathway with its reference as follows :-
  • Behen Root-Glucosinolates have Anti-Epilepsy --- (Kokate, c. & Purohit, A. (2016). pharmacognosy. nirali prakashan. )

  •   ►  URL --
  • https://www.sapnaonline.com/books/pharmacognosy-ck-kokate-8196396155-9788196396152 .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- NA CALCIUM with Lower blood vitamin E levels ..   FOLIC ACID with Reduces blood levels of folic acid dramatically increases homocysteine levels ..  

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf
    http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf


    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- CALCIUM with Long term use of anticonvulsant drug decreases blood levels of calcium ..  

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pd

    ►   Route of Elimination :   Renal
    Ref :-   Book : Martindale    Page : 561   Edition : 37.  

    ►    Plasma Half-life :   Min value :-   63 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 561   Edition : 37.  

    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   6 hours.  
    Ref :-   Book : Martindale    Page : 561   Edition : 37.