Zopiclone is a Medicine belongs to Hypnotic group whose information about Brand can be referenced from   Book : Martindale    Page : 1146   Edition : 37  

  ►   Brandname : espa-dorm, Optidorm, Somnosan, Imovane, Imrest, Zopicon, Zileze, Zimovane
  ►  Strength : Tablet with

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 1147   Edition : 37  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 1146   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Short-term management of insomnia Oral 7.5 mg Tablet Drug taken shortly before retiring. Treatment should start with a dose of 3.75 mg in elderly patients.

Ref :-  Book : Martindale    Page : 1146   Edition : 37  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1

Ref :- Book :    Page :    Edition :   
►  Side Effect : Bitter or metallic taste in the mouth, Drowsiness, Sedation, Muscle weakness, Ataxia, Vertigo, Headache, Confusion, Depression, Slurred speech, Dysarthria, Changes in libido, Tremor, Visual disturbances, Urinary retention, Urinary incontinence, Gastrointestinal disturbances, Changes in salivation, Amnesia, Paradoxical excitation, Raised liver enzyme values
Ref :-   Book : Martindale    Page : 1090, 1146   Edition : 37.  

►  Drug Interaction : Drug interaction of Zopiclone is with Alcohol, Antidepressant , Antipsychotics, General anaesthetics , Sedative antihistamines, opioid analgesics, ,  Carbamazapine , Phenytoin
Ref :-   Book : Martindale    Page : 1092, 1146   Edition : 37.  


  ►    Mechanism of Drug Drug Interaction :  Use with rifampicin or other potent inducers of the cytochrome P450 isoenzyme CYP3A4, such as carbamazepine or phenytoin, is likely to reduce the effects of zopiclone. Enhanced sedation or respiratory and cardiovascular depression may occur if diazepam or other benzodiazepines are given with other drugs that have CNS depressant properties; these include alcohol, antidepressants, sedative antihistamines, antipsychotics, general anaesthetics, other hypnotics or sedatives, and opioid analgesics. The metabolism of most banzodiazipines is mediated primarily by the cytochrome P450 system, particularly the isoenzymes CYP2C19 and CYP3A4. Hence, adverse effects may also be produce by use with drugs that inhibit or induce or metabolized by these isoenzymes. Benzodiazepines such as diazepam that are metabolised primarily by hepatic microsomal oxidation may be more susceptible to pharmacokinetic changes than those eliminated primarily by glucuronide conjugation.
Ref :-   Book : Martindale    Page : 1092, 1146   Edition : 37.  


►  Contraindication : Hepatic impairment, Myasthenia gravis, Pre-existing CNS depression or coma, Respiratory depression, Acute pulmonary insufficiency, Renal impairment, Sleep apnoea, Chronic pulmonary insufficiency, Zopiclone is not appropriate for the treatment of chronic psychosis or for phobic or obsessional states, Caution is required in patients with organic brain changes particularly arteriosclerosis
Ref :-   Book : Martindale    Page : 1092, 1146   Edition : 37.  
  ►  Mechanism of Action :   Its actions are mediated by enhancement of the activity of gammaaminobutyric acid (GABA) in the brain.
Ref :-   Book : Martindale    Page : 1146   Edition : 37.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


DIETARY Substance Interactions


​   ► This Medicine interact with :- CAFFEINE with Dietary Substance is Drug Enhancer.  

  ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20


    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- KAVA KAVA with It may cause excessive drowsiness when taken together ..  

      ►  Reference :-
  • Kokate, C. K, A.P. Purohit, and S.B. Gokhale. Pharmacognosy. 1st ed. Mumbai: Nirali Prakashan, 2014. Print.

  •   ►  URL -- https://books.google.co.in/books?id=KwYIsLRyDp4C&pg=SL1-PA102&lpg=SL1-PA102&dq=pharmacognosy+by+kokate&source=bl&ots=8hQsNxkE_6&sig=bmgn5pVpcZq0uZYw-x5pBtypxXs&hl=en&sa=X&ved=0ahUKEwiqrd6slarQAhVBuo8KHfrSCPYQ6AEIKzAD#v=onepage&q=pharmacognosy%20by%20kokat

    ►   Route of Elimination :   NA

    ►    Plasma Half-life :   Min value :-   NA    Max value :-   NA

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA