Zotepine is a Medicine belongs to Antipsychotics group whose information about Brand can be referenced from   Book : Martindale    Page : 1147   Edition : 37  

  ►   Brandname : Zoleptil, Nipolept
  ►  Strength : Tablet with

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 1147   Edition : 37  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 1147   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Schizophrenia Oral 25 mg Tablet t.i.d. This is increased according to response, at intervals of 4 days, to a maximum of 100 mg three times daily. There is an appreciable increase in the incidence of seizures at total daily doses above the recommended maximum of 300 mg.

Ref :-  Book : Martindale    Page : 1147   Edition : 37  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1

Ref :- Book :    Page :    Edition :   
►  Side Effect : Asthenia, Headache, Hypotension, Orthostatic hypotension, Tachycardia, Gastrointestinal disturbances, Elevated liver enzyme values, leucopenia, Agitation, Anxiety, Dizziness, Insomnia, Somnolence, Rhinitis, Sweating, Blurred Vision, Thrombocytopenia, Hyperglycaemia, Hyperlipidaemia, Convulsions, Sexual dysfunction, Urinary incontinence
Ref :-   Book : Martindale    Page : 1147   Edition : 37.  

►  Drug Interaction : Drug interaction of Zotepine is with Methyldopa , Clonidine , Fluoxetine , Diazepam
Ref :-   Book : Martindale    Page : 1147   Edition : 37.  


  ►    Mechanism of Drug Drug Interaction :  Zotepine may enhance the effects of other CNS depressants and antimuscarinics. The risk of seizures is particularly increased when zotepine is given with high doses of other antipsychotics. Additive hypotensive effects may theoretically occur with antihypertensives and some anaesthetic drugs; however its α-blocking actions might reduce the effects of methyldopa or clonidine. The risk of arrhythmias with zotepine may be increased by use with other drugs that prolong the QT interval or cause hypokalaemia. Use of zotepine with fluoxetine or diazepam may lead to increased plasma concentrations of zotepine
Ref :-   Book : Martindale    Page : 1447   Edition : 37.  


►  Contraindication : Zotepine can prolong the QT interval and patients with pre-existing prolongation of the QT interval should not be given the drug. It should be used with caution in patients at risk of developing arrhythmias; in such patients an ECG should be performed before starting treatment., Zotepine may also increase the heart rate and, consequently, it should be used with care in patients with angina pectoris due to coronary artery disease. Caution is also recommended in patients with other cardiovascular disorders such as severe hypertension., Zotepine has uricosuric properties and should not be given to patients with acute gout or a history of nephrolithiasis; it should be used with caution in patients with a history of gout or hyperuricaemia., It has antimuscarinic actions and should be used with caution in patients with disorders such as benign prostatic hyperplasia, urinary retention, angleclosure glaucoma, and paralytic ileus. It should also be used with caution in patients with hepatic impairment., Zotepine may exacerbate the symptoms of Parkinson’s disease. It should be used with caution in patients with tumours of the adrenal medulla such as phaeochromocytoma or neuroblastoma., Zotepine may affect the performance of skilled tasks including driving.
Ref :-   Book : Martindale    Page : 1147   Edition : 37.  
  ►  Mechanism of Action :   Zotepine is an atypical antipsychotic that, in addition to its antagonist action at central dopamine (D1 and D2) receptors, binds to serotonin (5-HT2), adrenergic (α1), and histamine (H1) receptors and also inhibits noradrenaline reuptake.
Ref :-   Book : Martindale    Page : 1447   Edition : 37.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Ashwagandha with Another pathway.  

  ►  Pathway with its reference as follows :-
  • Antipsychetic --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL --
  • http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- KAVA KAVA with It may cause excessive drowsiness when taken together ..  

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Pres

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf

    ►   Route of Elimination :   Hepatic (Metabolism), Renal, Faecal
    Ref :-   Book : Martindale    Page : 1147   Edition : 37.  

    ►    Plasma Half-life :   Min value :-   14 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1147   Edition : 37.  

    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   3 hours.  
    Ref :-   Book : Martindale    Page : 1147   Edition : 37.