Zotepine is a Medicine belongs to Antipsychotic group whose information about Brand can be referenced from   Book : Martindale    Page : 1147   Edition : 37,

  ►   Brandname : Zoleptil

  ►  Strength : Tablet with nf  ,

Reference of this Medicine for its Strength can be taken from   Book :    Page :    Edition : ,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 1147   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Schizophrenia Oral 25 mg Tablet t.i.d.

Ref :-  Book : Martindale    Page : 1147   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Orthostatic hypotension, tachycardia, gastrointestinal disturbance, elevation of liver enzymes, leukopenia, agitation, anxiety, Dizziness, insomnia, Somnolence, rhinitis, sweating, Blurred Vision, thrombocytopenia, Hyperglycaemia, hyperlipidaemia, convulsion, sexual dysfunction, urinary incontinence, Neuroleptic malignant syndrome,
Ref :-   Book : Martindale    Page : 1147   Edition : 37,

►  Drug Interaction : Drug interaction of Zotepine is with Phentolamine , Corticotropin , , Clopamide , Aminophylline , Methyldopa , Clonidine , Fluoxetine ,
Ref :-   Book : Martindale    Page : 1147   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Zotepine may enhance the effects of other CNS depressants and antimuscarinics. The risk of seizuresis particularly increased when zotepine is given with high doses of other antipsychotics. Additive hypotensive effects may theoretically occur with antihypertensives and some anaesthetic drugs; however its α-blocking actions might reduce the effects of methyldopa or clonidine. The risk of arrhythmias with zotepine may be increased by use with other drugs that prolong the QT interval or cause hypokalaemia. Use of zotepine with fluoxetine or diazepam may lead to increased plasma concentrations of zotepine,
Ref :-   Book : Martindale    Page : 1447   Edition : 37,


►  Contraindication : acute gout, angle -closure glucoma, hepatic impairment, Nephrolithiasis, paralytic ileus, prostatic hyperplasia, renal impairment, severe hypertension, urinary retention,
Ref :-   Book : Martindale    Page : 1147   Edition : 37,
  ►  Mechanism of Action :   Zotepine is an atypical antipsychotic that, in addition to its antagonist action at central dopamine (D1 and D2) receptors, binds to serotonin (5-HT2), adrenergic (α1), and histamine (H1) receptors and also inhibits noradrenaline reuptake.,
Ref :-   Book : Martindale    Page : 1447   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Ashwagandha with Another pathway,

  ►  Pathway with its reference as follows :-
  • Antipsychetic --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- IODINE with Dietary Substance is Drug Inhibitor,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- KAVA KAVA with It may cause excessive drowsiness when taken together .,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Pres

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,

    ►   Route of Elimination :   Fecal, Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 1147   Edition : 37,


    ►    Plasma Half-life :   Min value :-   14 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1147   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   3 hours,
    Ref :-   Book : Martindale    Page : 1147   Edition : 37,