caffeine is a Medicine belongs to CNS Stimulant group whose information about Brand can be referenced from   Book : Martindale    Page : 1206   Edition : 38, Martindale    Page : 1206   Edition : 38 ,

  ►   Brandname : Pro-Plus,Cafcit,Caffedrine,Enerjets,Keep Alert,peyona,Lucidex,NoDoz,StayAlert,Vivarin

  ►  Strength : Tablet with   , Injection with   , Oral solution with   , Capsule with   , Suppository with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 1206   Edition : 38, Martindale    Page : 1207   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV, rectal, IM,
Reference :-   Book : Martindale    Page : 1204   Edition : 38, Martindale    Page : 1207   Edition : 38, Martindale    Page : 1206   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 CNS stimulant Oral 50 100 mg
2 Analgesic Oral 15 65 mg
3 Migraine Oral 100 mg

Ref :-  Book : Martindale    Page : 1204   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Neonatal apnoea of prematurity > 1 Day > 28 Day Oral 20 mg/kg
2 Neonatal apnoea of prematurity > 1 Day > 28 Day IV infusion 20 mg/kg Injection

Ref :- Book : Martindale    Page : 1204   Edition : 38,
►  Side Effect : nausea, vomiting, abdominal pain, diarrhea, gastrointestinal disturbance, insomnia, headache, anxiety, irritability, Restlessness, tremor, palpitations,
Ref :-   Book : Martindale    Page : 1255   Edition : 37, Martindale    Page : 1205,1231   Edition : 38,

►  Drug Interaction : Drug interaction of caffeine is with MACROLIDES , Quinolones, Oral Contraceptive, Antiepileptics ,  Allopurinol , Abatacept , Cimetidine , Disulfiram, Fluvoxamine, Tiabendazole, Viloxazine, Phenytoin , Phenytoin , Ritonavir, Rifampicin , Sulfinpyrazone,
Ref :-   Book : Martindale    Page : 1206,1233   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Caffeine clearance may be reduced by interaction with other drugs including allopurinol, some antiarrhythmics, cimetidine, disulfiram, fluvoxamine, macrolide antibacterials and quinolones, oral contraceptives, tiabendazole, and viloxazine, and the dose of theophylline may need to be reduced. Phenytoin and some other antiepileptics, ritonavir, rifampicin, and sulfinpyrazone may increase Caffeine clearance, and require an increase in dose or dosing frequency of Caffeine.,
Ref :-   Book : Martindale    Page : 1206,1233   Edition : 38,


►  Contraindication : Peptic ulceration, Porphyria, hyperthyroidism, hypertension, Arrhythmia, cardiovascular disease, Epilepsy, heart failure, hepatic dysfunction, acute febrile illness,
Ref :-   Book : Martindale    Page : 1233   Edition : 38, Martindale    Page : 1205,1233   Edition : 38,
  ►  Mechanism of Action :   Caffeine is a methylxanthine that, like theophylline, inhibits the enzyme phosphodiesterase and has an antagonistic effect at central adenosine receptors It is a stimulant of the CNS, particularly the higher centres, and it can produce a condition of wakefulness and increased mental activity. It may also stimulate the respiratory centre, increasing the rate and depth of respiration. Caffeine facilitates the performance of muscular work and increases the total work that can be performed by a muscle. ,
Ref :-   Book : Martindale    Page : 1204   Edition : 38,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Tea with same compound, Caffeine with same compound, Onion with Another pathway,

  ►  Pathway with its reference as follows :-
  • Caffeine --- (Gopala,C(2007) , Nutritive Value of Indian food , Hyderabad ;Indian Council of medical research )
  • Same compound present in tea or coffee --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )
  • Antiasthematic property. --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- https://books.google.co.in/books/about/Nutritive_Value_of_Indian_Foods.html?id=biFBAAAAYAAJ, http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- CALCIUM with Decrease in Nutrient Level, SOYA with Dietary Substance is Drug Enhancer,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Driver, S. (2009). Stockleys Herbal Medicines Interactions. Royal pharmaceutical Society of Great Britain: Pharmaceutical press.

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf, https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- EPHEDRA with This combination may lead to dangerously increased heart rate and blood pressure and should be avoided by people with heart conditions , hypertension , diabetes or thyroid disease .,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 1206   Edition : 38,


    ►    Plasma Half-life :   Min value :-   3 hour,    Max value :-   7 hours,
    Ref :-   Book : Martindale    Page : 1206   Edition : 38,


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA