dextropropoxyphene is a Medicine belongs to opioid analgesics group whose information about Brand can be referenced from   Book : Martindale    Page : 43   Edition : 37  

  ►   Brandname : Doloxene, Parvodex, Darvon, Darvon-N
  ►  Strength : Tablet with .  Capsule with .  Oral Suspension with

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 43   Edition : 37  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 43   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Analgesics Oral 65 mg Tablet Dextropropoxyphene is mainly used with other analgesics that have anti-inflammatory and antipyretic effects, such as aspirin or paracetamol. In the USA the usual licensed dose is 65 mg of the hydrochloride or 100 mg of the napsilate given every 4 hours up to a maximum total daily dose of 390 mg or 600 mg, respectively. In the UK similar doses have been given three or four times daily

Ref :-  Book : Martindale    Page : 43   Edition : 37  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1

Ref :- Book :    Page :    Edition :   
►  Side Effect : Gastrointestinal effects, Dizziness, Drowsiness, Abnormal liver fuction tests, Nausea, Vomiting, Constipation, Dry mouth, Sweating, Facial flushing, Headache, Vertigo, Bradycardia, Tachycardia, palpitations, Orthostatic hypotension, Hypothermia, Restlessness, Changes in mood, Decreased libido or potency, Hallucinations, Miosis
Ref :-   Book : Martindale    Page : 42, 106   Edition : 37.  

►  Drug Interaction : Drug interaction of dextropropoxyphene is with CNS depressants, Alcohol, CNS stimulatns, antidepressants, BENZODIAZEPINES , Beta Blockers , Anaesthetics, Anxiolytics, Hypnotics, Tricyclic antidepressants,  Ritonavir, Carbamazapine , Phenobarbital , Phenytoin , Warfarin , Cyclizine , Mexiletine , Cisapride , Metoclopramide , Domperidone
Ref :-   Book : Martindale    Page : 42, 107   Edition : 37.  


  ►    Mechanism of Drug Drug Interaction :  Plasma concentrations of dextropropoxyphene are increased by ritonavir, with a resultant risk of toxicity; they should not be given together. CNS depressants, including alcohol, may contribute to the hazards of dextropropoxyphene. The convulsant action of high doses of dextropropoxyphene may be enhanced by CNS stimulants. Dextropropoxyphene interacts with several other drugs through inhibition of liver metabolism. Drugs reported to be affected include antidepressants , Benzodiazepines , beta blockers, carbamazepine , phenobarbital, phenytoin, and warfarin The depressant effects of opioid analgesics are enhanced by other CNS depressants such as alcohol, anaesthetics, anxiolytics, hypnotics, tricyclic antidepressants, and antipsychotics. Cyclizine may counteract the haemodynamic benefits of opioids. Gastrointestinal effects may delay absorption of mexiletine or may be counteractive as with cisapride, metoclopramide, or domperidone.
Ref :-   Book : Martindale    Page : 42, 107   Edition : 37.  


►  Contraindication : Acute respiratory depression and obstructive airway disease, Acute alcoholism, Convulsive disorders, Head injury, Hypothyroidism, Adrenocortical insufficiency, Renal impairment, Hepatic impairment, prostatic hyperplasia, Hypotension, shock, Inflammatory or obstructive bowel disorders, Myasthenia gravis, Conditions in which intracranial pressure is raised, Comatose patients, Avoided in patients at risk of paralytic ileus, Opioid analgesics should be given with great care to infants, especially neonates
Ref :-   Book : Martindale    Page : 43, 107   Edition : 37.  
  ►  Mechanism of Action :   It is an opioid analgesic with agonist activity mainly at μ opioid receptors
Ref :-   Book : Martindale    Page : 93, 43   Edition : 37.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Ononin with Another pathway.  

  ►  Pathway with its reference as follows :-
  • Analgesics effect . --- (PDR for herbal medicine. (2016) (4th ed.). Thomson Reuters, 2007. )

  •   ►  URL --
  • http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- PECTIN with Dietary Substance is Drug Inhibitor.  

      ►  Reference :-
  • Bushra, R. & Aslam, N. (2011). Food-Drug Interactions. Oman Medical Journal, 26(2), 77-83.

  •   ►  URL -- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191675/


    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- COCOA BEANS with It increased extent of absorption ..  

      ►  Reference :-
  • Bushra, R. & Aslam, N. (2011). Food-Drug Interactions. Oman Medical Journal, 26(2), 77-83.

  •   ►  URL -- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191675/

    ►   Route of Elimination :   Hepatic (Metabolism), Renal
    Ref :-   Book : Martindale    Page : 42   Edition : 37.  

    ►    Plasma Half-life :   Min value :-   6 hours,    Max value :-   12 hours.  
    Ref :-   Book : Martindale    Page : 43   Edition : 37.  

    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   2.5 hours.  
    Ref :-   Book : Martindale    Page : 42   Edition : 37.