dichloralphenazone is a Medicine belongs to Sedatives- hypnotics group whose information about Brand can be referenced from   Book : Martindale    Page : 1098   Edition : 37  

  ►   Brandname : Duradrin, Midrin, Migratine
  ►  Strength : Capsule with

Reference of this Medicine for its Strength can be taken from   Book : Harrison's principles of internal medicine    Page : 118   Edition : 18  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Harrison's principles of internal medicine    Page : 118   Edition : 18  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Acute migraine Oral 100 mg Capsule Given with Acetaminophen, 325 mg, plus isometheptene, 65 mg. Two capsules at onset followed by 1 capsule q1h (max 5 capsules)

Ref :-  Book : Harrison's principles of internal medicine    Page : 118   Edition : 18  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1

Ref :- Book :    Page :    Edition :   
►  Side Effect : Gastric irritation, Abdominal distension, Flatulence, Drowsiness, Lightheadedness, Ataxia, Headache, Paradoxical excitement, Hallucinations, Nightmares, Delirium, Confusion, Hypersensitivity reactions, Skin rashes, Erythema multiforme, Stevens-Johnson syndrome, Ketonuria
Ref :-   Book : Martindale    Page : 1082,1098   Edition : 37.  

►  Drug Interaction : Drug interaction of dichloralphenazone is with Alcohol, ,  Furosemide
Ref :-   Book : Martindale    Page : 1082,1098   Edition : 37.  


  ►    Mechanism of Drug Drug Interaction :  The sedative effects of dichloralphenazone are enhanced by other CNS depressants such as alcohol (the ‘Mickey Finn’ of detective fiction), barbiturates, and other sedatives. Dichloralphenazone may alter the effects of coumarin anticoagulants. A hypermetabolic state, apparently due to displacement of thyroid hormones from their binding proteins, has been reported in patients given an intravenous dose of furosemide subsequent to dichloralphenazone.
Ref :-   Book : Martindale    Page : 1082,1098   Edition : 37.  


►  Contraindication : It should not be used in patients with marked hepatic or renal impairment or severe cardiac disease, and oral dosage is best avoided in the presence of gastritis. , It can cause drowsiness that may persist the next day; affected patients should not drive or operate machinery, Use is best avoided during pregnancy
Ref :-   Book : Martindale    Page : 1082,1098   Edition : 37.  
  ►  Mechanism of Action :   Bind to specific GABAA receptor subunits at CNS neuronal synapsis increasing duration of GABA mediated chloride ion channel opening enhance membrane hyperpolarization.
Ref :-   Book : Basic & Clinical pharmacology    Page : 386   Edition : 12.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Poppy seed with Another pathway.  

  ►  Pathway with its reference as follows :-
  • sedative effect . --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL --
  • http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- KAVA KAVA with It may cause excessive drowsiness when taken with this drug ..  

      ►  Reference :-
  • Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html

    ►   Route of Elimination :   NA

    ►    Plasma Half-life :   Min value :-   NA    Max value :-   NA

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA