lomustine is a Medicine belongs to Antineoplastic group whose information about Brand can be referenced from   Book : Martindale    Page : 814   Edition : 37,

  ►   Brandname : CeeNU,CCNU

  ►  Strength : Capsules with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 814   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 814   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Antineoplastic Oral 120 130 mg/m2 Capsule Dose over 3 consecutive days may reduce gastrointestinal effects. A dose of 100 mg/m2 should be given to patients with compromised bone-marrow function.

Ref :-  Book : Martindale    Page : 814   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Antineoplastic Oral 120 130 mg/m2 Capsule

Ref :- Book : Martindale    Page : 814   Edition : 37,
►  Side Effect : neurological reactions, Confusion, lethargy, nausea, vomiting, Flushing of the skin, conjunctiva, hypotension, tachycardia, chest pain, headache, hypersensitivity reactions,
Ref :-   Book : Martindale    Page : 813   Edition : 37,

►  Drug Interaction : Drug interaction of lomustine is with NA

  ►    Mechanism of Drug Drug Interaction :  Because of their effects on the gastrointestinal mucosa antineoplastics have the potential to interfere with the absorption of drugs given orally. Antineoplastics that have an immunosuppressant effect may reduce the response to vaccines, and there is a possibility of generalised infection with live vaccines. Use with live vaccines should generally be avoided. Many antineoplastics are inhibitors of certain isoenzymes of cytochrome P450 and some antineoplastics are also metabolised by these enzymes, and in consequence the possibility of interactions between antineoplastics, or between antineoplastics and other medication, cannot be discounted.,
Ref :-   Book : Martindale    Page : 698,817   Edition : 37,


►  Contraindication : hepatic dysfunction, pregnancy,
Ref :-   Book : Martindale    Page : 813   Edition : 37,
  ►  Mechanism of Action :   The general mechanism of action of these drugs involves intramolecular cyclization to form an ethyleneimonium ion that may directly or through formation of a carbonium ion transfer an alkyl group to a cellular constituent.,
Ref :-   Book : Basic & Clinical pharmacology    Page : 953   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Bugula neritina with Another pathway,

  ►  Pathway with its reference as follows :-
  • Bryostatin have anticancer effect --- (Kokate, c. & Purohit, A. (2016). pharmacognosy. nirali prakashan. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 814   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   4 hours,
    Ref :-   Book : Basic & Clinical pharmacology    Page : 957   Edition : 12,