lopinavir and ritonavir (LPV/r) is a Medicine belongs to Anti-Retroviral Drugs group whose information about Brand can be referenced from   Book :

  ►   Brandname : NA
  ►  Strength : Capsule with 133.3+33.3 mg.  Solution with 400+100/5 mg/ml.  Tablet with 100+25 mg.  Tablet with 200+50 mg. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 989   Edition : 12   Martindale    Page : 989   Edition : 37  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 989   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 HIV infection Oral 400 mg b.d. Dose: given with ritonavir 100 mg)
2 AIDS Oral 400 mg b.d. Dose: given with ritonavir 100 mg)
3 HIV infection Oral 533 mg Solution b.d. Dose: Given with ritonavir 133 mg.
4 AIDS Oral 533 mg Solution Dose: Given with ritonavir 133 mg.

Ref :-  Book : Martindale    Page : 990   Edition : 37  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 HIV infection <2 Year Oral 230 mg/m2 Solution b.d.
2 HIV infection 14 Day 6 Month Oral 16 mg/kg b.d.
3 HIV infection <6 Month Less than 15 kg Oral 12 mg/kg b.d.
4 HIV infection 15-40 kg Oral 10 mg/kg b.d.

Ref :- Book : Martindale    Page : 990   Edition : 37  
►  Side Effect : Diarrhea, Asthenia, Headache, Insomnia, Pain, Paraesthesia, Gastrointestinal disturbance, Acne, Rashes
Ref :-   Book : Martindale    Page : 989   Edition : 37.  

►  Drug Interaction : Drug interaction of lopinavir and ritonavir (LPV/r) is with Rifampicin , Cocaine , Caffeine , Ergometrine , Ergotamine, Methylergometrine, Nicardipine , , Baclofen , Insulin
Ref :-   Book : Martindale    Page : 989.1   Edition : 37.  


  ►    Mechanism of Drug Drug Interaction :  NA


►  Contraindication : Pancreatitis, Hepatic impairment, Pregnancy, Renal impairment
Ref :-   Book : Martindale    Page : 989   Edition : 37.  
  ►  Mechanism of Action :   NA

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Turmeric with Another pathway.  

  ►  Pathway with its reference as follows :-
  • Curcumin proved to be an effective compound to inhibit the HIV-1 LTR-directed gene expression without any major effects on cell viability --- (: Zorofchian Moghadamtousi, Soheil et al. "A Review On Antibacterial, Antiviral, And Antifungal Activity Of Curcumin". BioMed Research International 2014 (2014): 1-12. Web. )

  •   ►  URL --
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022204/ .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   NA

    ►    Plasma Half-life :   Min value :-   NA    Max value :-   NA

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA