lopinavir and ritonavir (LPV/r) is a Medicine belongs to Anti-Retroviral Drugs group whose information about Brand can be referenced from   Book :

  ►   Brandname : NA

  ►  Strength : Capsule with 133.3+33.3  mg, Solution with 400+100/5  mg/ml, Tablet with 100+25  mg, Tablet with 200+50  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 989   Edition : 12, Martindale    Page : 989   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 989   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 HIV infection Oral 400 mg b.d. Dose: given with ritonavir 100 mg)
2 AIDS Oral 400 mg b.d. Dose: given with ritonavir 100 mg)
3 HIV infection Oral 533 mg Solution b.d. Dose: Given with ritonavir 133 mg.
4 AIDS Oral 533 mg Solution Dose: Given with ritonavir 133 mg.

Ref :-  Book : Martindale    Page : 990   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 HIV infection <2 Year Oral 230 mg/m2 Solution b.d.
2 HIV infection 14 Day 6 Month Oral 16 mg/kg b.d.
3 HIV infection <6 Month Less than 15 kg Oral 12 mg/kg b.d.
4 HIV infection 15-40 kg Oral 10 mg/kg b.d.

Ref :- Book : Martindale    Page : 990   Edition : 37,
►  Side Effect : diarrhea, asthenia, headache, insomnia, Pain, paraesthesia, gastrointestinal disturbance, acne, Rashes,
Ref :-   Book : Martindale    Page : 989   Edition : 37,

►  Drug Interaction : Drug interaction of lopinavir and ritonavir (LPV/r) is with Rifampicin , Cocaine , caffeine , Ergometrine , Ergotamine, Methylergometrine, Nicardipine , , Baclofen , Insulin ,
Ref :-   Book : Martindale    Page : 989.1   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  NA


►  Contraindication : pancreatitis, hepatic impairment, pregnancy, renal impairment,
Ref :-   Book : Martindale    Page : 989   Edition : 37,
  ►  Mechanism of Action :   NA

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Turmeric with Another pathway,

  ►  Pathway with its reference as follows :-
  • Curcumin proved to be an effective compound to inhibit the HIV-1 LTR-directed gene expression without any major effects on cell viability --- (: Zorofchian Moghadamtousi, Soheil et al. "A Review On Antibacterial, Antiviral, And Antifungal Activity Of Curcumin". BioMed Research International 2014 (2014): 1-12. Web. )

  •   ►  URL -- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022204/,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- RIBOFLAVIN with Decrease in Nutrient Level,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   NA


    ►    Plasma Half-life :
      Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA